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Kurt Giles
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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
SB Prusiner, AL Woerman, DA Mordes, JC Watts, R Rampersaud, ...
Proceedings of the National Academy of Sciences 112 (38), E5308-E5317, 2015
7482015
Transmission of multiple system atrophy prions to transgenic mice
JC Watts, K Giles, A Oehler, L Middleton, DT Dexter, SM Gentleman, ...
Proceedings of the National Academy of Sciences 110 (48), 19555-19560, 2013
4432013
Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions
J Stöhr, JC Watts, ZL Mensinger, A Oehler, SK Grillo, SJ DeArmond, ...
Proceedings of the National Academy of Sciences 109 (27), 11025-11030, 2012
4422012
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II
G Kryger, M Harel, K Giles, L Toker, B Velan, A Lazar, C Kronman, ...
Acta Crystallographica Section D: Biological Crystallography 56 (11), 1385-1394, 2000
3922000
Diagnosis of human prion disease
JG Safar, MD Geschwind, C Deering, S Didorenko, M Sattavat, ...
Proceedings of the National Academy of Sciences 102 (9), 3501-3506, 2005
3472005
Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients
JC Watts, C Condello, J Stöhr, A Oehler, J Lee, SJ DeArmond, L Lannfelt, ...
Proceedings of the National Academy of Sciences 111 (28), 10323-10328, 2014
3282014
Design and construction of diverse mammalian prion strains
DW Colby, K Giles, G Legname, H Wille, IV Baskakov, SJ DeArmond, ...
Proceedings of the National Academy of Sciences 106 (48), 20417-20422, 2009
2532009
Propagation of prions causing synucleinopathies in cultured cells
AL Woerman, J Stöhr, A Aoyagi, R Rampersaud, Z Krejciova, JC Watts, ...
Proceedings of the National Academy of Sciences 112 (35), E4949-E4958, 2015
2492015
Transmission of elk and deer prions to transgenic mice
G Tamgüney, K Giles, E Bouzamondo-Bernstein, PJ Bosque, MW Miller, ...
Journal of virology 80 (18), 9104-9114, 2006
2192006
Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice
J Stöhr, C Condello, JC Watts, L Bloch, A Oehler, M Nick, SJ DeArmond, ...
Proceedings of the National Academy of Sciences 111 (28), 10329-10334, 2014
1922014
Continuous quinacrine treatment results in the formation of drug-resistant prions
S Ghaemmaghami, M Ahn, P Lessard, K Giles, G Legname, ...
PLoS pathogens 5 (11), e1000673, 2009
1742009
Drug resistance confounding prion therapeutics
DB Berry, D Lu, M Geva, JC Watts, S Bhardwaj, A Oehler, AR Renslo, ...
Proceedings of the National Academy of Sciences 110 (44), E4160-E4169, 2013
1562013
Inactivation of prions by acidic sodium dodecyl sulfate
D Peretz, S Supattapone, K Giles, J Vergara, Y Freyman, P Lessard, ...
Journal of virology 80 (1), 322-331, 2006
1522006
Evidence that bank vole PrP is a universal acceptor for prions
JC Watts, K Giles, S Patel, A Oehler, SJ DeArmond, SB Prusiner
PLoS pathogens 10 (4), e1003990, 2014
1332014
Genes contributing to prion pathogenesis
G Tamgüney, K Giles, DV Glidden, P Lessard, H Wille, P Tremblay, ...
Journal of General Virology 89 (7), 1777-1788, 2008
1332008
Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease
C Condello, T Lemmin, J Stöhr, M Nick, Y Wu, AM Maxwell, JC Watts, ...
Proceedings of the National Academy of Sciences 115 (4), E782-E791, 2018
1312018
Bioluminescence imaging of Aβ deposition in bigenic mouse models of Alzheimer's disease
JC Watts, K Giles, SK Grillo, A Lemus, SJ DeArmond, SB Prusiner
Proceedings of the National Academy of Sciences 108 (6), 2528-2533, 2011
1212011
Resistance of bovine spongiform encephalopathy (BSE) prions to inactivation
K Giles, DV Glidden, R Beckwith, R Seoanes, D Peretz, SJ DeArmond, ...
PLoS pathogens 4 (11), e1000206, 2008
1042008
Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein
JC Watts, K Giles, J Stöhr, A Oehler, S Bhardwaj, SK Grillo, S Patel, ...
Proceedings of the National Academy of Sciences 109 (9), 3498-3503, 2012
862012
aCHEdb: the database system for ESTHER, the α/β fold family of proteins and the Cholinesterase gene server
X Cousin, T Hotelier, K Giles, J Pierre Toutant, A Chatonnet
Nucleic acids research 26 (1), 226-228, 1998
841998
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