Huawei Chen
Huawei Chen
Foghorn Therapeutics
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The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors
M Hedvat, D Huszar, A Herrmann, JM Gozgit, A Schroeder, A Sheehy, ...
Cancer cell 16 (6), 487-497, 2009
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines
CT Walsh, H Chen, TA Keating, BK Hubbard, HC Losey, L Luo, ...
Current opinion in chemical biology 5 (5), 525-534, 2001
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia
EK Keeton, K McEachern, KS Dillman, S Palakurthi, Y Cao, MR Grondine, ...
Blood, The Journal of the American Society of Hematology 123 (6), 905-913, 2014
Coumarin formation in novobiocin biosynthesis: β-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI
H Chen, CT Walsh
Chemistry & biology 8 (4), 301-312, 2001
Structural basis of substrate methylation and inhibition of SMYD2
AD Ferguson, NA Larsen, T Howard, H Pollard, I Green, C Grande, ...
Structure 19 (9), 1262-1273, 2011
BRD4 inhibition is synthetic lethal with PARP inhibitors through the induction of homologous recombination deficiency
C Sun, J Yin, Y Fang, J Chen, KJ Jeong, X Chen, CP Vellano, Z Ju, ...
Cancer cell 33 (3), 401-416. e8, 2018
Formation of β-hydroxy histidine in the biosynthesis of nikkomycin antibiotics
H Chen, BK Hubbard, SE O'Connor, CT Walsh
Chemistry & biology 9 (1), 103-112, 2002
CloQ, a prenyltransferase involved in clorobiocin biosynthesis
F Pojer, E Wemakor, B Kammerer, H Chen, CT Walsh, SM Li, L Heide
Proceedings of the National Academy of Sciences 100 (5), 2316-2321, 2003
Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1
J Wu, K Mikule, W Wang, N Su, P Petteruti, F Gharahdaghi, E Code, X Zhu, ...
ACS chemical biology 8 (10), 2201-2208, 2013
Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol
J Wu, F Powell, NA Larsen, Z Lai, KF Byth, J Read, RF Gu, M Roth, ...
ACS chemical biology 8 (3), 643-650, 2013
Deoxysugars in glycopeptide antibiotics: Enzymatic synthesis of TDP-l-epivancosamine in chloroeremomycin biosynthesis
H Chen, MG Thomas, BK Hubbard, HC Losey, CT Walsh, MD Burkart
Proceedings of the National Academy of Sciences 97 (22), 11942-11947, 2000
AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic MalignanciesBivalent BET Bromodomain Inhibitor AZD5153
GW Rhyasen, MM Hattersley, Y Yao, A Dulak, W Wang, P Petteruti, ...
Molecular cancer therapeutics 15 (11), 2563-2574, 2016
Glycopeptide antibiotic biosynthesis: Enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine
H Chen, CC Tseng, BK Hubbard, CT Walsh
Proceedings of the National Academy of Sciences 98 (26), 14901-14906, 2001
Potent and selective bivalent inhibitors of BET bromodomains
MJ Waring, H Chen, AA Rabow, G Walker, R Bobby, S Boiko, ...
Nature chemical biology 12 (12), 1097-1104, 2016
Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit
H Chen, S O’Connor, DE Cane, CT Walsh
Chemistry & biology 8 (9), 899-912, 2001
Development of a novel B-cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6
W McCoull, T Cheung, E Anderson, P Barton, J Burgess, K Byth, Q Cao, ...
ACS Chemical Biology 13 (11), 3131-3141, 2018
Discovery of novel benzylidene-1, 3-thiazolidine-2, 4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
LA Dakin, MH Block, H Chen, E Code, JE Dowling, X Feng, AD Ferguson, ...
Bioorganic & medicinal chemistry letters 22 (14), 4599-4604, 2012
Biosynthesis of mycarose: isolation and characterization of enzymes involved in the C-2 deoxygenation
H Chen, G Agnihotri, Z Guo, NLS Que, XH Chen, HW Liu
BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer
DO Adeegbe, S Liu, MM Hattersley, M Bowden, CW Zhou, S Li, R Vlahos, ...
Cancer immunology research 6 (10), 1234-1245, 2018
Aminoacyl-S-Enzyme Intermediates in β-Hydroxylations and α,β-Desaturations of Amino Acids in Peptide Antibiotics
H Chen, MG Thomas, SE O'Connor, BK Hubbard, MD Burkart, CT Walsh
Biochemistry 40 (39), 11651-11659, 2001
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