Leonardo Cortez
Leonardo Cortez
Research associate, University of Alberta
Verified email at
Cited by
Cited by
The therapeutic potential of chemical chaperones in protein folding diseases
L Cortez, V Sim
Prion 8 (2), 197-202, 2014
Bile acids reduce prion conversion, reduce neuronal loss, and prolong male survival in models of prion disease
LM Cortez, J Campeau, G Norman, M Kalayil, J Van der Merwe, ...
Journal of virology 89 (15), 7660-7672, 2015
Early stages of aggregation of engineered α-synuclein monomers and oligomers in solution
X Li, C Dong, M Hoffmann, CR Garen, LM Cortez, NO Petersen, ...
Scientific Reports 9 (1), 1734, 2019
Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein
AN Gupta, K Neupane, N Rezajooei, LM Cortez, VL Sim, MT Woodside
Nature Communications 7 (1), 12058, 2016
Aggregation state and neurotoxic properties of Alzheimer β-amyloid peptide
A Mohamed, L Cortez, E Posse de Chaves
Current Protein and Peptide Science 12 (3), 235-257, 2011
Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication in α-synuclein aggregation
CM Torres-Bugeau, CL Ávila, R Raisman-Vozari, D Papy-Garcia, R Itri, ...
Journal of Biological Chemistry 287 (4), 2398-2409, 2012
Toll‐like receptor‐mediated immune response inhibits prion propagation
SG Kang, C Kim, LM Cortez, M Carmen Garza, J Yang, H Wille, VL Sim, ...
Glia 64 (6), 937-951, 2016
Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism
LM Cortez, J Kumar, L Renault, HS Young, VL Sim
Journal of Biological Chemistry 288 (7), 4772-4781, 2013
Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of …
LM Cortez, SK Nemani, C Duque Velásquez, A Sriraman, YL Wang, ...
PLoS Pathogens 17 (6), e1009703, 2021
Native nanodiscs formed by styrene maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids
M Esmaili, BP Tancowny, X Wang, A Moses, LM Cortez, VL Sim, H Wille, ...
Journal of Biological Chemistry 295 (25), 8460-8469, 2020
Implications of prion polymorphisms
LM Cortez, VL Sim
Prion 7 (4), 276-279, 2013
Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology
Q Wu, L Cortez, R Kamali-Jamil, V Sim, H Wille, S Kar
Disease Models & Mechanisms 14 (10), dmm048929, 2021
Quaternary Structure Changes for PrPSc Predate PrPC Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease
G Eskandari-Sedighi, LM Cortez, J Yang, N Daude, K Shmeit, V Sim, ...
Molecular Neurobiology 58 (1), 375-390, 2021
Redox-active tyrosine residue in the microcin J25 molecule
MC Chalón, N Wilke, J Pedersen, S Rufini, RD Morero, L Cortez, ...
Biochemical and Biophysical Research Communications 406 (3), 366-370, 2011
Glyceraldehyde-3-phosphate dehydrogenase tetramer dissociation and amyloid fibril formation induced by negatively charged membranes
LM Cortez, CL Ávila, CMT Bugeau, RN Farías, RD Morero, RN Chehín
FEBS letters 584 (3), 625-630, 2010
Interactions between α-conotoxin MI and the Torpedo marmorata receptor α–δ interface
L Cortez, C Marino-Buslje, MB de Jiménez Bonino, U Hellman
Biochemical and biophysical research communications 355 (1), 275-279, 2007
Conotoxin MI inhibits the α–δ acetylcholine binding site of the Torpedo marmorata receptor
LM Cortez, SG del Canto, FD Testai, MJB de Jiménez Bonino
Biochemical and biophysical research communications 295 (4), 791-795, 2002
The therapeutic potential of chemical chaperones in protein folding diseases. Prion 8: 197–202
L Cortez, V Sim
Distinctive toll-like receptors gene expression and glial response in different brain regions of natural scrapie
M García-Martínez, LM Cortez, A Otero, M Betancor, B Serrano-Pérez, ...
International Journal of Molecular Sciences 23 (7), 3579, 2022
Probing the origin of prion protein misfolding via reconstruction of ancestral proteins
LM Cortez, AJ Morrison, CR Garen, S Patterson, T Uyesugi, R Petrosyan, ...
Protein Science 31 (12), e4477, 2022
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