Andrea Cavalli
Andrea Cavalli
Director, CECAM, EPFL-Lausanne (CH) - Professor, University of Bologna (IT)
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Multi-target-directed ligands to combat neurodegenerative diseases
A Cavalli, ML Bolognesi, A Minarini, M Rosini, V Tumiatti, M Recanatini, ...
Journal of medicinal chemistry 51 (3), 347-372, 2008
Role of molecular dynamics and related methods in drug discovery
M De Vivo, M Masetti, G Bottegoni, A Cavalli
Journal of medicinal chemistry 59 (9), 4035-4061, 2016
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K+ channel blockers
A Cavalli, E Poluzzi, F De Ponti, M Recanatini
Journal of medicinal chemistry 45 (18), 3844-3853, 2002
Insight Into the Kinetic of Amyloid β (1–42) Peptide Self‐Aggregation: Elucidation of Inhibitors’ Mechanism of Action
M Bartolini, C Bertucci, ML Bolognesi, A Cavalli, C Melchiorre, ...
ChemBioChem 8 (17), 2152-2161, 2007
Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview
F De Ponti, E Poluzzi, A Cavalli, M Recanatini, N Montanaro
Drug safety 25, 263-286, 2002
QT prolongation through hERG K+ channel blockade: Current knowledge and strategies for the early prediction during drug development
M Recanatini, E Poluzzi, M Masetti, A Cavalli, F De Ponti
Medicinal research reviews 25 (2), 133-166, 2005
3-(4-{[Benzyl(methyl)amino]methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) Inhibits Both Acetylcholinesterase and Acetylcholinesterase-Induced β …
L Piazzi, A Rampa, A Bisi, S Gobbi, F Belluti, A Cavalli, M Bartolini, ...
Journal of medicinal chemistry 46 (12), 2279-2282, 2003
Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer’s disease
ML Bolognesi, A Cavalli, L Valgimigli, M Bartolini, M Rosini, V Andrisano, ...
Journal of medicinal chemistry 50 (26), 6446-6449, 2007
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds
L Piazzi, A Cavalli, F Colizzi, F Belluti, M Bartolini, F Mancini, ...
Bioorganic & medicinal chemistry letters 18 (1), 423-426, 2008
Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania
A Cavalli, ML Bolognesi
Journal of Medicinal Chemistry 52 (23), 7339-7359, 2009
Inhibition of acetylcholinesterase, β-amyloid aggregation, and NMDA receptors in Alzheimer’s disease: a promising direction for the multi-target-directed ligands gold rush
M Rosini, E Simoni, M Bartolini, A Cavalli, L Ceccarini, N Pascu, ...
Journal of medicinal chemistry 51 (15), 4381-4384, 2008
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition
V Limongelli, M Bonomi, L Marinelli, FL Gervasio, A Cavalli, E Novellino, ...
Proceedings of the National Academy of Sciences 107 (12), 5411-5416, 2010
A small molecule targeting the multifactorial nature of Alzheimer's disease
A Cavalli, ML Bolognesi, S Capsoni, V Andrisano, M Bartolini, E Margotti, ...
Angewandte Chemie International Edition 46 (20), 3689-3692, 2007
A catalytically silent FAAH-1 variant drives anandamide transport in neurons
J Fu, G Bottegoni, O Sasso, R Bertorelli, W Rocchia, M Masetti, A Guijarro, ...
Nature neuroscience 15 (1), 64-69, 2012
SAR of 9-amino-1, 2, 3, 4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues
M Recanatini, A Cavalli, F Belluti, L Piazzi, A Rampa, A Bisi, S Gobbi, ...
Journal of medicinal chemistry 43 (10), 2007-2018, 2000
Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis
F Altznauer, S Conus, A Cavalli, G Folkers, HU Simon
Journal of Biological Chemistry 279 (7), 5947-5957, 2004
Multitarget drug discovery and polypharmacology
ML Bolognesi, A Cavalli
ChemMedChem 11 (12), 1190-1192, 2016
Single-molecule pulling simulations can discern active from inactive enzyme inhibitors
F Colizzi, R Perozzo, L Scapozza, M Recanatini, A Cavalli
Journal of the American Chemical Society 132 (21), 7361-7371, 2010
Structural basis of cis-and trans-combretastatin binding to tubulin
R Gaspari, AE Prota, K Bargsten, A Cavalli, MO Steinmetz
Chem 2 (1), 102-113, 2017
Organocatalytic asymmetric conjugate addition of 1, 3‐dicarbonyl compounds to maleimides
G Bartoli, M Bosco, A Carlone, A Cavalli, M Locatelli, A Mazzanti, P Ricci, ...
Angewandte Chemie 118 (30), 5088-5092, 2006
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