Marcus Pickhardt
Marcus Pickhardt
DZNE, Bonn
Verified email at
Cited by
Cited by
Lest we forget you—methylene blue…
RH Schirmer, H Adler, M Pickhardt, E Mandelkow
Neurobiology of aging 32 (12), 2325. e7-2325. e16, 2011
Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs
I Khlistunova, J Biernat, Y Wang, M Pickhardt, M von Bergen, Z Gazova, ...
Journal of Biological Chemistry 281 (2), 1205-1214, 2006
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
M Pickhardt, Z Gazova, M von Bergen, I Khlistunova, Y Wang, A Hascher, ...
Journal of Biological Chemistry 280 (5), 3628-3635, 2005
Development of tau aggregation inhibitors for Alzheimer's disease
B Bulic, M Pickhardt, B Schmidt, EM Mandelkow, H Waldmann, ...
Angewandte Chemie International Edition 48 (10), 1740-1752, 2009
Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model
YP Wang, J Biernat, M Pickhardt, E Mandelkow, EM Mandelkow
Proceedings of the National Academy of Sciences 104 (24), 10252-10257, 2007
Tau protein and tau aggregation inhibitors
B Bulic, M Pickhardt, EM Mandelkow, E Mandelkow
Neuropharmacology 59 (4-5), 276-289, 2010
Curcumin‐derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?
R Narlawar, M Pickhardt, S Leuchtenberger, K Baumann, S Krause, ...
ChemMedChem: Chemistry Enabling Drug Discovery 3 (1), 165-172, 2008
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy
B Bulic, M Pickhardt, I Khlistunova, J Biernat, EM Mandelkow, ...
The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis
M von Bergen, S Barghorn, SA Müller, M Pickhardt, J Biernat, ...
Biochemistry 45 (20), 6446-6457, 2006
Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation
E Akoury, M Pickhardt, M Gajda, J Biernat, E Mandelkow, M Zweckstetter
Angewandte Chemie International Edition 52 (12), 3511-3515, 2013
Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of τ aggregation and toxicity in vitro and in cells
M Pickhardt, G Larbig, I Khlistunova, A Coksezen, B Meyer, ...
Biochemistry 46 (35), 10016-10023, 2007
Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau
K Hochgräfe, A Sydow, D Matenia, D Cadinu, S Könen, O Petrova, ...
Acta neuropathologica communications 3, 1-22, 2015
Cellular and humoral immune response in progressive multifocal leukoencephalopathy
F Weber, C Goldmann, M Krämer, FJ Kaup, M Pickhardt, P Young, H Petry, ...
Annals of neurology 49 (5), 636-642, 2001
Progress and developments in tau aggregation inhibitors for Alzheimer disease
B Bulic, M Pickhardt, E Mandelkow
Journal of medicinal chemistry 56 (11), 4135-4155, 2013
Screening for inhibitors of tau polymerization
M Pickhardt, M Bergen, Z Gazova, A Hascher, J Biernat, EM Mandelkow, ...
Current alzheimer research 2 (2), 219-226, 2005
Inhibition of tau filament formation by conformational modulation
E Akoury, M Gajda, M Pickhardt, J Biernat, P Soraya, C Griesinger, ...
Journal of the American Chemical Society 135 (7), 2853-2862, 2013
Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping
G Larbig, M Pickhardt, DG Lloyd, B Schmidt, E Mandelkow
Current Alzheimer Research 4 (3), 315-323, 2007
Inhibition of tau aggregation in cell models of tauopathy
I Khlistunova, M Pickhardt, J Biernat, Y Wang, EM Mandelkow, ...
Current Alzheimer Research 4 (5), 544-546, 2007
N-phenylamine derivatives as aggregation inhibitors in cell models of tauopathy
M Pickhardt, J Biernat, I Khlistunova, YP Wang, Z Gazova, EM Mandelkow, ...
Current Alzheimer Research 4 (4), 397-402, 2007
Identification of small molecule inhibitors of tau aggregation by targeting monomeric tau as a potential therapeutic approach for tauopathies
M Pickhardt, T Neumann, D Schwizer, K Callaway, M Vendruscolo, ...
Current Alzheimer Research 12 (9), 814-828, 2015
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