Prions activate a p38 MAPK synaptotoxic signaling pathway C Fang, B Wu, NTT Le, T Imberdis, RCC Mercer, DA Harris PLoS pathogens 14 (9), e1007283, 2018 | 69 | 2018 |
The prion protein modulates A-type K+ currents mediated by Kv4. 2 complexes through dipeptidyl aminopeptidase-like protein 6 RCC Mercer, L Ma, JC Watts, R Strome, S Wohlgemuth, J Yang, ... Journal of Biological Chemistry 288 (52), 37241-37255, 2013 | 45 | 2013 |
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation A Lau, A McDonald, N Daude, CE Mays, ED Walter, R Aglietti, ... EMBO molecular medicine 7 (3), 339-356, 2015 | 39 | 2015 |
Endoproteolytic processing of the mammalian prion glycoprotein family CE Mays, J Coomaraswamy, JC Watts, J Yang, KWS Ko, B Strome, ... The FEBS journal 281 (3), 862-876, 2014 | 29 | 2014 |
A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS … RCC Mercer, N Daude, L Dorosh, ZL Fu, CE Mays, H Gapeshina, ... PLoS pathogens 14 (1), e1006826, 2018 | 25 | 2018 |
Mechanisms of prion-induced toxicity RCC Mercer, DA Harris Cell and Tissue Research 392 (1), 81-96, 2023 | 17 | 2023 |
Identification of anti-prion drugs and targets using toxicity-based assays RCC Mercer, DA Harris Current opinion in pharmacology 44, 20-27, 2019 | 8 | 2019 |
Prion diseases RCC Mercer, AJ McDonald, E Bove-Fenderson, C Fang, B Wu, DA Harris The Molecular and Cellular Basis of Neurodegenerative Diseases, 23-56, 2018 | 7 | 2018 |
Vertebrate slow skeletal muscle actin—conservation, distribution and conformational flexibility RCC Mercer, WAKA Mudalige, TO Ige, DH Heeley Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1814 (10), 1253-1260, 2011 | 7 | 2011 |
P4‐506: ROLE OF P38α MAP KINASE IN AMYLOID‐β DERIVED DIFFUSIBLE LIGAND (ADDL) INDUCED DENDRITIC SPINE LOSS IN HIPPOCAMPAL NEURONS L Amin, N Le, RCC Mercer, U Germann, J Alam, DA Harris Alzheimer's & Dementia 15, P1507-P1507, 2019 | 3 | 2019 |
Prion Proteins and the Alzheimer Disease A beta Amyloid Cascade D Westaway, K Alier, D Vergote, D MacTavish, R Mercer, W Fu, J Yang, ... Prion 5, 1-2, 2011 | 3 | 2011 |
Slow skeletal muscle actin RCC Mercer, WAKA Mudalige, DH Heeley Biophysical Journal 96 (3), 124a, 2009 | 1 | 2009 |
Abnormal synaptic architecture in iPSC-derived neurons from a multi-generational family with genetic Creutzfeldt-Jakob disease AD Gojanovich, NTT Le, RCC Mercer, S Park, B Wu, A Anane, ... Stem Cell Reports 19 (10), 1474-1488, 2024 | | 2024 |
Sigma Receptor Ligands Are Potent Antiprion Compounds that Act Independently of Sigma Receptor Binding RCC Mercer, NTT Le, DG Fraser, MCQ Houser, AB Beeler, DA Harris ACS Chemical Neuroscience, 2024 | | 2024 |
NMDA receptor misalignment in iPSC-derived neurons from a multi-generational family with inherited Creutzfeldt-Jakob disease NTT Le, RCC Mercer, AD Gojanovich, A Anane, S Park, B Wu, PS Bawa, ... bioRxiv, 2022.05. 20.491674, 2022 | | 2022 |
Identification of Receptors for TDP-43 That Mediate Cellular Uptake and Neurotoxicity RC Mercer | | 2022 |
Signalling pathways underlying prion neurotoxicity NT Le, RC Mercer, DA Harris PRION 13, 17-17, 2019 | | 2019 |
'Novel compounds for the treatment of prion disease' RCC Mercer, NTT Le, D Fraser, A Beeler, DA Harris PRION 13, 128-128, 2019 | | 2019 |
Propagation of Misfolded Proteins in Neurodegeneration: Insights and Cautions from the Study of Prion Disease Prototypes RCC Mercer, N Daude, D Westaway Protein Folding Disorders Of The Central Nervous System, 203, 2017 | | 2017 |
The Prion Protein: Modulation of Potassium Channels and a Novel Mouse Model of a Disease-Causing Hydrophobic Domain Insertion Mutation RCC Mercer | | 2016 |