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Robert C.C. Mercer
Robert C.C. Mercer
Instructor, Boston University Chobanian & Avedisian School of Medicine
Verified email at bu.edu
Title
Cited by
Cited by
Year
Prions activate a p38 MAPK synaptotoxic signaling pathway
C Fang, B Wu, NTT Le, T Imberdis, RCC Mercer, DA Harris
PLoS pathogens 14 (9), e1007283, 2018
622018
The prion protein modulates A-type K+ currents mediated by Kv4. 2 complexes through dipeptidyl aminopeptidase-like protein 6
RCC Mercer, L Ma, JC Watts, R Strome, S Wohlgemuth, J Yang, ...
Journal of Biological Chemistry 288 (52), 37241-37255, 2013
402013
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation
A Lau, A McDonald, N Daude, CE Mays, ED Walter, R Aglietti, ...
EMBO molecular medicine 7 (3), 339-356, 2015
372015
Endoproteolytic processing of the mammalian prion glycoprotein family
CE Mays, J Coomaraswamy, JC Watts, J Yang, KWS Ko, B Strome, ...
The FEBS journal 281 (3), 862-876, 2014
292014
A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS …
RCC Mercer, N Daude, L Dorosh, ZL Fu, CE Mays, H Gapeshina, ...
PLoS pathogens 14 (1), e1006826, 2018
232018
Mechanisms of prion-induced toxicity
RCC Mercer, DA Harris
Cell and Tissue Research 392 (1), 81-96, 2023
112023
Identification of anti-prion drugs and targets using toxicity-based assays
RCC Mercer, DA Harris
Current opinion in pharmacology 44, 20-27, 2019
82019
Prion diseases
RCC Mercer, AJ McDonald, E Bove-Fenderson, C Fang, B Wu, DA Harris
The Molecular and Cellular Basis of Neurodegenerative Diseases, 23-56, 2018
72018
Vertebrate slow skeletal muscle actin—conservation, distribution and conformational flexibility
RCC Mercer, WAKA Mudalige, TO Ige, DH Heeley
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1814 (10), 1253-1260, 2011
52011
Prion Proteins and the Alzheimer Disease A beta Amyloid Cascade
D Westaway, K Alier, D Vergote, D MacTavish, R Mercer, W Fu, J Yang, ...
Prion 5, 1-2, 2011
32011
P4‐506: ROLE OF P38α MAP KINASE IN AMYLOID‐β DERIVED DIFFUSIBLE LIGAND (ADDL) INDUCED DENDRITIC SPINE LOSS IN HIPPOCAMPAL NEURONS
L Amin, N Le, RCC Mercer, U Germann, J Alam, DA Harris
Alzheimer's & Dementia 15, P1507-P1507, 2019
22019
Slow skeletal muscle actin
RCC Mercer, WAKA Mudalige, DH Heeley
Biophysical Journal 96 (3), 124a, 2009
12009
Sigma Receptor Ligands Are Potent Antiprion Compounds that Act Independently of Sigma Receptor Binding
RCC Mercer, NTT Le, DG Fraser, MCQ Houser, AB Beeler, DA Harris
ACS Chemical Neuroscience, 2023
2023
NMDA receptor misalignment in iPSC-derived neurons from a multi-generational family with inherited Creutzfeldt-Jakob disease
NTT Le, RCC Mercer, AD Gojanovich, A Anane, S Park, B Wu, PS Bawa, ...
bioRxiv, 2022.05. 20.491674, 2022
2022
Identification of Receptors for TDP-43 That Mediate Cellular Uptake and Neurotoxicity
RC Mercer, BOSTON UNIV MEDICAL CAMPUS MA
2022
Signalling pathways underlying prion neurotoxicity
NT Le, RC Mercer, DA Harris
PRION 13, 17-17, 2019
2019
'Novel compounds for the treatment of prion disease'
RCC Mercer, NTT Le, D Fraser, A Beeler, DA Harris
PRION 13, 128-128, 2019
2019
Propagation of Misfolded Proteins in Neurodegeneration: Insights and Cautions from the Study of Prion Disease Prototypes
RCC Mercer, N Daude, D Westaway
Protein Folding Disorders Of The Central Nervous System, 203, 2017
2017
The Prion Protein: Modulation of Potassium Channels and a Novel Mouse Model of a Disease-Causing Hydrophobic Domain Insertion Mutation
RCC Mercer
2016
Transgenic mouse expressing a novel Gerstmann-Straussler-Scheinker disease Prnp allele with a partial duplication of the PrP hydrophobic domain
RCC Mercer, CE Mays, N Daude, H Gapeshina, SL Wohlgemuth, J Yang, ...
PRION 8, 114-115, 2014
2014
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Articles 1–20