| Adaptive designs in clinical trials: why use them, and how to run and report them P Pallmann, AW Bedding, B Choodari-Oskooei, M Dimairo, L Flight, ... BMC medicine 16, 1-15, 2018 | 573 | 2018 |
| Tadalafil pharmacokinetics in healthy subjects ST Forgue, BE Patterson, AW Bedding, CD Payne, DL Phillips, ... British journal of clinical pharmacology 61 (3), 280-288, 2006 | 340 | 2006 |
| Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 α-blockers, doxazosin and tamsulosin in healthy normotensive men RA Kloner, G Jackson, JT Emmick, MI Mitchell, A Bedding, MR Warner, ... The Journal of urology 172 (5), 1935-1940, 2004 | 232 | 2004 |
| Effect of tadalafil on cytochrome P450 3A4–mediated clearance: studies in vitro and in vivo BJ Ring, BE Patterson, MI Mitchell, M Vandenbranden, J Gillespie, ... Clinical pharmacology & therapeutics 77 (1), 63-75, 2005 | 103 | 2005 |
| IL-17–high asthma with features of a psoriasis immunophenotype J Östling, M van Geest, JPR Schofield, Z Jevnikar, S Wilson, J Ward, ... Journal of Allergy and Clinical Immunology 144 (5), 1198-1213, 2019 | 97 | 2019 |
| How to design a dose-finding study using the continual reassessment method GM Wheeler, AP Mander, A Bedding, K Brock, V Cornelius, AP Grieve, ... BMC medical research methodology 19, 1-15, 2019 | 92 | 2019 |
| The effect of intrinsic and extrinsic factors on the pharmacokinetic properties of tadalafil (IC351) B Patterson, A Bedding, H Jewell, C Payne, M Mitchell Int J Impot Res 13 (Suppl 5), S62, 2001 | 78 | 2001 |
| Stratification of asthma phenotypes by airway proteomic signatures JPR Schofield, D Burg, B Nicholas, F Strazzeri, J Brandsma, D Staykova, ... Journal of Allergy and Clinical Immunology 144 (1), 70-82, 2019 | 71 | 2019 |
| Clinical trial protocol for TRANSFORM-UK: a therapeutic open-label study of tocilizumab in the treatment of pulmonary arterial hypertension J Hernández-Sánchez, L Harlow, C Church, S Gaine, E Knightbridge, ... Pulmonary circulation 8 (1), 2045893217735820, 2017 | 71 | 2017 |
| Effects of gender, age, diabetes mellitus and renal and hepatic impairment on tadalafil pharmacokinetics ST Forgue, DL Phillips, AW Bedding, CD Payne, H Jewell, BE Patterson, ... British journal of clinical pharmacology 63 (1), 24-35, 2007 | 68 | 2007 |
| Adaptive design: results of 2012 survey on perception and use CC Morgan, S Huyck, M Jenkins, L Chen, A Bedding, CS Coffey, ... Therapeutic Innovation & Regulatory Science 48 (4), 473-481, 2014 | 60 | 2014 |
| Adaptive dose-response studies B Gaydos, M Krams, I Perevozskaya, F Bred, Q Liu, P Gallo, D Berry, ... Drug information journal 40 (4), 451-461, 2006 | 56 | 2006 |
| The pharmacokinetics of ondansetron after intravenous injection in healthy volunteers phenotyped as poor or extensive metabolisers of debrisoquine. EI Ashforth, JL Palmer, A Bye, A Bedding British journal of clinical pharmacology 37 (4), 389-391, 1994 | 52 | 1994 |
| Dose-normalized pharmacokinetics of tadalafil (IC351) administered as a single dose to healthy volunteers B Patterson, A Bedding, H Jewell, C Payne, M Mitchell Int J Impot Res 13 (suppl 5), S62, 2001 | 47 | 2001 |
| A computational framework for complex disease stratification from multiple large-scale datasets B De Meulder, D Lefaudeux, AT Bansal, A Mazein, A Chaiboonchoe, ... BMC systems biology 12, 1-23, 2018 | 40 | 2018 |
| The combined use of ibutilide as an active control with intensive electrocardiographic sampling and signal averaging as a sensitive method to assess the effects of tadalafil on … CM Beasley, MI Mitchell, AA Dmitrienko, JT Emmick, W Shen, ... Journal of the American College of Cardiology 46 (4), 678-687, 2005 | 39 | 2005 |
| Pharmacodynamic interactions between tadalafil and nitrates compared with sildenafil RA Kloner, MI Mitchell, A Bedding, J Emmick JOURNAL OF UROLOGY 167 (4), 176-177, 2002 | 38 | 2002 |
| The effect of tadalafil on the time to exercise‐induced myocardial ischaemia in subjects with coronary artery disease D Patterson, R Kloner, M Effron, J Emmick, A Bedding, M Warner, ... British journal of clinical pharmacology 60 (5), 459-468, 2005 | 30 | 2005 |
| Cardiovascular profile of tadalafil, a new PDE5 inhibitor RA Kloner, VS Watkins, TM Costigan, A Bedding, MI Mitchell, J Emmick Journal of Urology 167 (4), 176-176, 2002 | 30 | 2002 |
| Simulation practices for adaptive trial designs in drug and device development C Mayer, I Perevozskaya, S Leonov, V Dragalin, Y Pritchett, A Bedding, ... Statistics in Biopharmaceutical Research 11 (4), 325-335, 2019 | 25 | 2019 |
