Tim U. Krohne
Tim U. Krohne
Dept. of Ophthalmology, Univ. of Cologne, Germany
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Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans
TU Krohne, N Eter, FG Holz, CH Meyer
American journal of ophthalmology 146 (4), 508-512, 2008
TNF-α mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations
AM Joussen, S Doehmen, ML Le, K Koizumi, S Radetzky, TU Krohne, ...
Molecular vision 15, 1418, 2009
Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans
TU Krohne, Z Liu, FG Holz, CH Meyer
American journal of ophthalmology 154 (4), 682-686. e2, 2012
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina
A Weidemann, TU Krohne, E Aguilar, T Kurihara, N Takeda, MI Dorrell, ...
Glia 58 (10), 1177-1185, 2010
Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells
TU Krohne, NK Stratmann, J Kopitz, FG Holz
Experimental eye research 90 (3), 465-471, 2010
Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis
E Kaemmerer, F Schutt, TU Krohne, FG Holz, J Kopitz
Investigative ophthalmology & visual science 48 (3), 1342-1347, 2007
Mouse α-fetoprotein–specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice
CF Grimm, D Ortmann, L Mohr, S Michalak, TU Krohne, S Meckel, ...
Gastroenterology 119 (4), 1104-1112, 2000
Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans
CH Meyer, TU Krohne, FG Holz
Retina 31 (9), 1877-1884, 2011
Comparing alternative ranibizumab dosages for safety and efficacy in retinopathy of prematurity: a randomized clinical trial
A Stahl, TU Krohne, N Eter, I Oberacher-Velten, R Guthoff, S Meltendorf, ...
JAMA pediatrics 172 (3), 278-286, 2018
Generation of Retinal Pigment Epithelial Cells from Small Molecules and OCT4 Reprogrammed Human Induced Pluripotent Stem Cells
TU Krohne, PD Westenskow, T Kurihara, DF Friedlander, M Lehmann, ...
Stem cells translational medicine 1 (2), 96-109, 2012
Gene therapy of hepatocellular carcinoma in vitro and in vivo in nude mice by adenoviral transfer of the escherichia coli purine nucleoside phosphorylase gene
L Mohr, S Shankara, SK Yoon, TU Krohne, M Geissler, B Roberts, ...
Hepatology 31 (3), 606-614, 2000
Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action
TU Krohne, E Kaemmerer, FG Holz, J Kopitz
Experimental eye research 90 (2), 261-266, 2010
Modulation of three key innate immune pathways for the most common retinal degenerative diseases
I Akhtar‐Schäfer, L Wang, TU Krohne, H Xu, T Langmann
EMBO molecular medicine 10 (10), e8259, 2018
Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro
TU Krohne, S Shankara, M Geissler, BL Roberts, JR Wands, HE Blum, ...
Hepatology 34 (3), 511-518, 2001
Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage
C Brandstetter, LKM Mohr, E Latz, FG Holz, TU Krohne
Journal of Molecular Medicine 93, 905-916, 2015
In-depth mass spectrometric mapping of the human vitreous proteome
S Aretz, TU Krohne, K Kammerer, U Warnken, A Hotz-Wagenblatt, ...
Proteome science 11 (1), 1-10, 2013
Pathological but not physiological retinal neovascularization is altered in TNF-Rp55-receptor–deficient mice
N Kociok, S Radetzky, TU Krohne, C Gavranic, AM Joussen
Investigative ophthalmology & visual science 47 (11), 5057-5065, 2006
Complement component C5a primes retinal pigment epithelial cells for inflammasome activation by lipofuscin-mediated photooxidative damage
C Brandstetter, FG Holz, TU Krohne
Journal of Biological Chemistry 290 (52), 31189-31198, 2015
Growth suppression of the hepatocellular carcinoma cell line Hepa1-6 by an activatable interferon regulatory factor-1 in mice
A Kröger, D Ortmann, TU Krohne, L Mohr, HE Blum, H Hauser, ...
Cancer research 61 (6), 2609-2617, 2001
New pharmacologic approaches to therapy for age-related macular degeneration
N Eter, TU Krohne, FG Holz
BioDrugs 20, 167-179, 2006
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