| Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities SJ Tabrizi, MD Flower, CA Ross, EJ Wild Nature Reviews Neurology 16 (10), 529-546, 2020 | 299 | 2020 |
| DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases C Bettencourt, D Hensman‐Moss, M Flower, S Wiethoff, A Brice, C Goizet, ... Annals of neurology 79 (6), 983-990, 2016 | 231 | 2016 |
| MSH3 modifies somatic instability and disease severity in Huntington’s and myotonic dystrophy type 1 M Flower, V Lomeikaite, M Ciosi, S Cumming, F Morales, K Lo, ... Brain 142 (7), 1876-1886, 2019 | 140 | 2019 |
| FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat R Goold, M Flower, DH Moss, C Medway, A Wood-Kaczmar, R Andre, ... Human molecular genetics 28 (4), 650-661, 2019 | 134 | 2019 |
| A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes M Ciosi, A Maxwell, SA Cumming, DJH Moss, AM Alshammari, MD Flower, ... EBioMedicine 48, 568-580, 2019 | 133 | 2019 |
| Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities SJ Tabrizi, C Estevez-Fraga, WMC van Roon-Mom, MD Flower, RI Scahill, ... The Lancet Neurology 21 (7), 645-658, 2022 | 117 | 2022 |
| Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease DJ Hensman Moss, MD Flower, KK Lo, JRC Miller, GJB van Ommen, ... Scientific reports 7 (1), 44849, 2017 | 53 | 2017 |
| Subcellular localization and formation of huntingtin aggregates correlates with symptom onset and progression in a Huntington’s disease model C Landles, RE Milton, N Ali, R Flomen, M Flower, F Schindler, ... Brain communications 2 (2), fcaa066, 2020 | 37 | 2020 |
| FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington’s disease R Goold, J Hamilton, T Menneteau, M Flower, EL Bunting, SG Aldous, ... Cell reports 36 (9), 2021 | 34 | 2021 |
| Therapeutic strategies for Huntington's disease C Estevez-Fraga, MD Flower, SJ Tabrizi Current opinion in neurology 33 (4), 508-518, 2020 | 28 | 2020 |
| Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues A Neueder, K Kojer, T Hering, DJ Lavery, J Chen, N Birth, J Hallitsch, ... Genome biology 23 (1), 189, 2022 | 15 | 2022 |
| Dystrophin deficiency affects human astrocyte properties and response to damage J Lange, O Gillham, R Alkharji, S Eaton, G Ferrari, M Madej, M Flower, ... Glia 70 (3), 466-490, 2022 | 11 | 2022 |
| PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington’s disease J Lange, O Gillham, M Flower, H Ging, S Eaton, S Kapadia, A Neueder, ... Progress in Neurobiology 225, 102448, 2023 | 7 | 2023 |
| TRACK-HD team; Enroll-HD team, A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington … M Ciosi, A Maxwell, SA Cumming, DJ Hensman Moss, AM Alshammari, ... EBioMedicine 48, 568-580, 2019 | 6 | 2019 |
| Huntingtin lowering reduces somatic instability at CAG-expanded loci SR Coffey, M Andrew, H Ging, J Hamilton, M Flower, M Kovalenko, ... bioRxiv, 2020.07. 23.218347, 2020 | 5 | 2020 |
| Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington’s disease M Papoutsi, M Flower, DJ Hensman Moss, P Holmans, C Estevez-Fraga, ... Brain Communications 4 (6), fcac279, 2022 | 4 | 2022 |
| A small molecule kicks repeat expansion into reverse MD Flower, SJ Tabrizi Nature Genetics 52 (2), 136-137, 2020 | 4 | 2020 |
| Status epilepticus caused by an unusual encephalopathy M Flower, K Ali, C Lawthom Practical Neurology 15 (1), 56-59, 2015 | 4 | 2015 |
| Genetic modifiers of repeat expansion disorders S Rajagopal, J Donaldson, M Flower, DJ Hensman Moss, SJ Tabrizi Emerging Topics in Life Sciences 7 (3), 325-337, 2023 | 3 | 2023 |
| Reply: The repeat variant in MSH3 is not a genetic modifier for spinocerebellar ataxia type 3 and Friedreich’s ataxia M Flower, V Lomeikaite, P Holmans, L Jones, SJ Tabrizi, DG Monckton Brain 143 (4), e26-e26, 2020 | 2 | 2020 |
