Michael Burczynski (aka Michael Ransom)
Michael Burczynski (aka Michael Ransom)
Regeneron Pharmaceuticals
Verified email at - Homepage
Cited by
Cited by
Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1–AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the …
TM Penning, ME Burczynski, JM Jez, CF Hung, HK Lin, H Ma, M Moore, ...
Biochemical journal 351 (1), 67-77, 2000
The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities
S Pant, H Hilton, ME Burczynski
Biochemical pharmacology 83 (11), 1484-1494, 2012
Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones
TM Penning, ME Burczynski, CF Hung, KD McCoull, NT Palackal, ...
Chemical research in toxicology 12 (1), 1-18, 1999
Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells
ME Burczynski, M McMillian, J Ciervo, L Li, JB Parker, RT Dunn, S Hicken, ...
Toxicological sciences 58 (2), 399-415, 2000
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
KD Davis, N Aghaeepour, AH Ahn, MS Angst, D Borsook, A Brenton, ...
Nature Reviews Neurology 16 (7), 381-400, 2020
Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells
ME Burczynski, RL Peterson, NC Twine, KA Zuberek, BJ Brodeur, ...
The journal of molecular diagnostics 8 (1), 51-61, 2006
Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression
F Allantaz, DT Cheng, T Bergauer, P Ravindran, MF Rossier, M Ebeling, ...
PloS one 7 (1), e29979, 2012
Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative …
ME Burczynski, HK Lin, TM Penning
Cancer research 59 (3), 607-614, 1999
Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR‐623, a novel liver X‐receptor agonist, in healthy participants
A Katz, C Udata, E Ott, L Hickey, ME Burczynski, P Burghart, O Vesterqvist, ...
The Journal of Clinical Pharmacology 49 (6), 643-649, 2009
The reactive oxygen species-and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the α, β-unsaturated aldehyde 4-hydroxy-2-nonenal to 1, 4-dihydroxy-2-nonene
ME Burczynski, GR Sridhar, NT Palackal, TM Penning
Journal of Biological Chemistry 276 (4), 2890-2897, 2001
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor
ME Burczynski, TM Penning
Cancer research 60 (4), 908-915, 2000
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein γ-secretase for the treatment of Alzheimer's disease
RL Martone, H Zhou, K Atchison, T Comery, JZ Xu, X Huang, X Gong, ...
Journal of Pharmacology and Experimental Therapeutics 331 (2), 598-608, 2009
Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies
ME Burczynski, AJ Dorner
Pharmacogenomics 7 (2), 187-202, 2006
Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma
NC Twine, JA Stover, B Marshall, G Dukart, M Hidalgo, W Stadler, ...
Cancer research 63 (18), 6069-6075, 2003
Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7, 8-dihydrobenzo [a] pyrene to the activated o …
ME Burczynski, RG Harvey, TM Penning
Biochemistry 37 (19), 6781-6790, 1998
The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation
NT Palackal, ME Burczynski, RG Harvey, TM Penning
Biochemistry 40 (36), 10901-10910, 2001
Transcriptional profiles in peripheral blood mononuclear cells prognostic of clinical outcomes in patients with advanced renal cell carcinoma
ME Burczynski, NC Twine, G Dukart, B Marshall, M Hidalgo, WM Stadler, ...
Clinical cancer research 11 (3), 1181-1189, 2005
Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)
TM Penning, ME Burczynski, JM Jez, HK Lin, H Ma, M Moore, K Ratnam, ...
Molecular and cellular endocrinology 171 (1-2), 137-149, 2001
Measurement of myostatin concentrations in human serum: circulating concentrations in young and older men and effects of testosterone administration
KM Lakshman, S Bhasin, C Corcoran, LA Collins-Racie, L Tchistiakova, ...
Molecular and cellular endocrinology 302 (1), 26-32, 2009
Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis
MK McMillian, ER Grant, Z Zhong, JB Parker, L Li, RA Zivin, ...
In Vitro & Molecular Toxicology: A Journal of Basic and Applied Research 14 …, 2001
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