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Leah V Sibener, PhD
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Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
JT Sockolosky, E Trotta, G Parisi, L Picton, LL Su, AC Le, A Chhabra, ...
Science 359 (6379), 1037-1042, 2018
2912018
Antigen identification for orphan T cell receptors expressed on tumor-infiltrating lymphocytes
MH Gee, A Han, SM Lofgren, JF Beausang, JL Mendoza, ME Birnbaum, ...
Cell 172 (3), 549-563. e16, 2018
2712018
Isolation of a structural mechanism for uncoupling T cell receptor signaling from peptide-MHC binding
LV Sibener, RA Fernandes, EM Kolawole, CB Carbone, F Liu, D McAffee, ...
Cell 174 (3), 672-687. e27, 2018
2602018
Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells
AM Luoma, CD Castro, T Mayassi, LA Bembinster, L Bai, D Picard, ...
Immunity 39 (6), 1032-1042, 2013
2482013
Nanoscale artificial antigen presenting cells for T cell immunotherapy
K Perica, ADL Medero, M Durai, YL Chiu, JG Bieler, L Sibener, ...
Nanomedicine: Nanotechnology, Biology and Medicine 10 (1), 119-129, 2014
1552014
Genetic variation in MHC proteins is associated with T cell receptor expression biases
E Sharon, LV Sibener, A Battle, HB Fraser, KC Garcia, JK Pritchard
Nature genetics 48 (9), 995-1002, 2016
1492016
Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity
JJ Adams, S Narayanan, ME Birnbaum, SS Sidhu, SJ Blevins, MH Gee, ...
Nature immunology 17 (1), 87-94, 2016
1302016
Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T‐cell receptor
J López‐Sagaseta, LV Sibener, JE Kung, J Gumperz, EJ Adams
The EMBO journal 31 (8), 2047-2059, 2012
752012
Tuning T cell receptor sensitivity through catch bond engineering
X Zhao, EM Kolawole, W Chan, Y Feng, X Yang, MH Gee, KM Jude, ...
Science 376 (6589), eabl5282, 2022
582022
Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo
RA Fernandes, C Li, G Wang, X Yang, CS Savvides, CR Glassman, ...
Elife 9, e58463, 2020
302020
Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro
MH Gee, LV Sibener, ME Birnbaum, KM Jude, X Yang, RA Fernandes, ...
Proceedings of the National Academy of Sciences 115 (31), E7369-E7378, 2018
262018
Identification of antigenic targets
HP Gerber, LV Sibener, LJ Lee, MH Gee
Trends in Cancer 6 (4), 299-318, 2020
92020
Intracellular targets as source for cleaner targets for the treatment of solid tumors
HP Gerber, LV Sibener, LJ Lee, M Gee
Biochemical Pharmacology 168, 275-284, 2019
92019
Voices of biotech leaders
AE Abong, K Bosley, C Casebourn, P Chan, J Chen, M Chen, G Church, ...
Nature Biotechnology 39 (6), 654-660, 2021
42021
TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways
W Chan, YM Cao, X Zhao, EC Schrom, D Jia, J Song, LV Sibener, S Dong, ...
Journal of Experimental Medicine 220 (12), e20231242, 2023
32023
Isolation and visualization of a structural trigger that uncouples TCR signaling from PMHC binding
LV Sibener, RA Fernandes, EM Kolawole, CB Carbone, F Liu, D McAffee, ...
Cell 174 (3), 672, 2018
22018
T cell receptor (tcr) compositions and methods for optimizing antigen reactive t-cells
L Sibener, J Leonard, M Gee, J Byers
US Patent App. 18/157,605, 2023
2023
T cell receptor (tcr) compositions and methods for optimizing antigen reactive t-cells
L Sibener, J Leonard, A Ramirez, M Gee
US Patent App. 18/157,598, 2023
2023
T cell receptor (tcr) compositions and methods for optimizing antigen reactive t-cells
L Sibener, J Leonard, M Gee
US Patent App. 18/157,623, 2023
2023
T cell receptor (tcr) compositions and methods for optimizing antigen reactive t-cells
L Sibener, A Ramirez, J Leonard, M Gee, DV Liu
US Patent App. 18/157,616, 2023
2023
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