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Mohammad T Mazhab-Jafari
Mohammad T Mazhab-Jafari
Assistant Professor of Medical biophysics, University of Toronto
Adresă de e-mail confirmată pe uhnresearch.ca - Pagina de pornire
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Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
MT Mazhab-Jafari, CB Marshall, MJ Smith, GMC Gasmi-Seabrook, ...
Proceedings of the National Academy of Sciences 112 (21), 6625-6630, 2015
2022015
Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase
MT Mazhab-Jafari, A Rohou, C Schmidt, SA Bueler, S Benlekbir, ...
Nature 539 (7627), 118-122, 2016
1582016
Molecular basis of human CD22 function and therapeutic targeting
J Ereño-Orbea, T Sicard, H Cui, MT Mazhab-Jafari, S Benlekbir, A Guarné, ...
Nature communications 8 (1), 764, 2017
1292017
The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants
R Selvaratnam, B VanSchouwen, F Fogolari, MT Mazhab-Jafari, R Das, ...
Biophysical journal 102 (3), 630-639, 2012
962012
Dynamically driven ligand selectivity in cyclic nucleotide binding domains
R Das, S Chowdhury, MT Mazhab-Jafari, S SilDas, R Selvaratnam, ...
Journal of Biological Chemistry 284 (35), 23682-23696, 2009
872009
The auto-inhibitory role of the EPAC hinge helix as mapped by NMR
R Selvaratnam, MT Mazhab-Jafari, R Das, G Melacini
PloS one 7 (11), e48707, 2012
842012
Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc
MT Mazhab-Jafari, CB Marshall, PB Stathopulos, Y Kobashigawa, ...
Journal of the American Chemical Society 135 (9), 3367-3370, 2013
742013
Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP
R Das, MT Mazhab-Jafari, S Chowdhury, S SilDas, R Selvaratnam, ...
Journal of Biological Chemistry 283 (28), 19691-19703, 2008
702008
Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states
MT Mazhab-Jafari, R Das, SA Fotheringham, S SilDas, S Chowdhury, ...
Journal of the American Chemical Society 129 (46), 14482-14492, 2007
552007
Real-time NMR study of three small GTPases reveals that fluorescent 2′(3′)-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics
MT Mazhab-Jafari, CB Marshall, M Smith, GMC Gasmi-Seabrook, ...
Journal of Biological Chemistry 285 (8), 5132-5136, 2010
532010
Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts
CB Marshall, D Meiri, MJ Smith, MT Mazhab-Jafari, ...
Methods 57 (4), 473-485, 2012
512012
A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues
D Long, CB Marshall, G Bouvignies, MT Mazhab‐Jafari, MJ Smith, M Ikura, ...
Angewandte Chemie 125 (41), 10971-10974, 2013
492013
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation
Z Xu, JH Choi, DL Dai, J Luo, RJ Ladak, Q Li, Y Wang, C Zhang, S Wiebe, ...
Proceedings of the National Academy of Sciences 119 (32), e2204539119, 2022
422022
An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis
MT Mazhab-Jafari, CB Marshall, N Ishiyama, J Ho, V Di Palma, ...
Structure 20 (9), 1528-1539, 2012
422012
Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR)
MT Mazhab-Jafari, CB Marshall, J Ho, N Ishiyama, V Stambolic, M Ikura
Journal of Biological Chemistry 289 (18), 12195-12201, 2014
242014
Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase
JW Lou, KR Iyer, SMN Hasan, LE Cowen, MT Mazhab-Jafari
Scientific Reports 9 (1), 12987, 2019
232019
Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases
MT Mazhab-Jafari, JL Rubinstein
Science Advances 2 (7), e1600725, 2016
222016
Biochemical classification of disease-associated mutants of RAS-like protein expressed in many tissues (RIT1)
Z Fang, CB Marshall, JC Yin, MT Mazhab-Jafari, GMC Gasmi-Seabrook, ...
Journal of Biological Chemistry 291 (30), 15641-15652, 2016
202016
Biochemical classification of disease-associated mutants of RAS-like protein expressed in many tissues (RIT1)
Z Fang, CB Marshall, JC Yin, MT Mazhab-Jafari, GMC Gasmi-Seabrook, ...
Journal of Biological Chemistry 291 (30), 15641-15652, 2016
202016
Label-Free Assay for Thermodynamic Analysis of Protein− Ligand Interactions: A Multivariate Strategy for Allosteric Ligand Screening
JMA Gavina, MT Mazhab-Jafari, G Melacini, P Britz-McKibbin
Biochemistry 48 (2), 223-225, 2009
142009
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