Johan H. van Es
Johan H. van Es
KNAW Hubrecht Institute
Verified email at
Cited by
Cited by
Identification of stem cells in small intestine and colon by marker gene Lgr5
N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ...
Nature 449 (7165), 1003-1007, 2007
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ...
Nature 459 (7244), 262-265, 2009
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ...
Gastroenterology 141 (5), 1762-1772, 2011
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ...
Nature 469 (7330), 415-418, 2011
Crypt stem cells as the cells-of-origin of intestinal cancer
N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ...
Nature 457 (7229), 608-611, 2009
Caught up in a Wnt storm: Wnt signaling in cancer
RH Giles, JH Van Es, H Clevers
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1653 (1), 1-24, 2003
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ...
Cell 143 (1), 134-144, 2010
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
JH van Es, ME Van Gijn, O Riccio, M Van Den Born, M Vooijs, H Begthel, ...
Nature 435 (7044), 959-963, 2005
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ...
Cell stem cell 6 (1), 25-36, 2010
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
M Van de Wetering, R Cavallo, D Dooijes, M van Beest, J van Es, ...
Cell 88 (6), 789-799, 1997
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
M Huch, C Dorrell, SF Boj, JH Van Es, VSW Li, M Van De Wetering, ...
Nature 494 (7436), 247-250, 2013
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ...
Nature 476 (7360), 293-297, 2011
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
AG Schepers, HJ Snippert, DE Stange, M van den Born, JH van Es, ...
Science 337 (6095), 730-735, 2012
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
V Jaks, N Barker, M Kasper, JH Van Es, HJ Snippert, H Clevers, ...
Nature genetics 40 (11), 1291-1299, 2008
Mutations in the APC tumour suppressor gene cause chromosomal instability
R Fodde, J Kuipers, C Rosenberg, R Smits, M Kielman, C Gaspar, ...
Nature cell biology 3 (4), 433-438, 2001
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine
APG Haramis, H Begthel, M Van Den Born, J Van Es, S Jonkheer, ...
Science 303 (5664), 1684-1686, 2004
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
BK Koo, M Spit, I Jordens, TY Low, DE Stange, M Van De Wetering, ...
Nature 488 (7413), 665-669, 2012
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
HJ Snippert, A Haegebarth, M Kasper, V Jaks, JH van Es, N Barker, ...
Science 327 (5971), 1385-1389, 2010
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers
J Muñoz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ...
The EMBO journal 31 (14), 3079-3091, 2012
Transcription factor achaete scute-like 2 controls intestinal stem cell fate
LG van der Flier, ME van Gijn, P Hatzis, P Kujala, A Haegebarth, ...
Cell 136 (5), 903-912, 2009
The system can't perform the operation now. Try again later.
Articles 1–20