A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria A Mbengue, S Bhattacharjee, T Pandharkar, H Liu, G Estiu, RV Stahelin, ... Nature 520 (7549), 683-687, 2015 | 725 | 2015 |
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ... Nature communications 3 (1), 1288, 2012 | 305 | 2012 |
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma T Hideshima, J Qi, RM Paranal, W Tang, E Greenberg, N West, ... Proceedings of the National Academy of Sciences 113 (46), 13162-13167, 2016 | 140 | 2016 |
Structural origin of selectivity in class II-selective histone deacetylase inhibitors G Estiu, E Greenberg, CB Harrison, NP Kwiatkowski, R Mazitschek, ... Journal of medicinal chemistry 51 (10), 2898-2906, 2008 | 137 | 2008 |
Synthesis and conformation− activity relationships of the peptide isosteres of FK228 and largazole AA Bowers, TJ Greshock, N West, G Estiu, SL Schreiber, O Wiest, ... Journal of the American Chemical Society 131 (8), 2900-2905, 2009 | 126 | 2009 |
Blueprint for antimicrobial hit discovery targeting metabolic networks Y Shen, J Liu, G Estiu, B Isin, YY Ahn, DS Lee, AL Barabási, V Kapatral, ... Proceedings of the National Academy of Sciences 107 (3), 1082-1087, 2010 | 125 | 2010 |
The hydrolysis of urea and the proficiency of urease G Estiu, KM Merz Journal of the American Chemical Society 126 (22), 6932-6944, 2004 | 115 | 2004 |
Kinetic, mechanistic, and DFT study of the electrophilic reactions of nitrosyl complexes with hydroxide F Roncaroli, ME Ruggiero, DW Franco, GL Estiú, JA Olabe Inorganic chemistry 41 (22), 5760-5769, 2002 | 115 | 2002 |
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs JD Herman, LR Pepper, JF Cortese, G Estiu, K Galinsky, V Zuzarte-Luis, ... Science translational medicine 7 (288), 288ra77-288ra77, 2015 | 110 | 2015 |
Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABAA receptor complex M Marder, G Estiú, LB Blanch, H Viola, C Wasowski, JH Medina, ... Bioorganic & medicinal chemistry 9 (2), 323-335, 2001 | 103 | 2001 |
On the inhibition of histone deacetylase 8 G Estiu, N West, R Mazitschek, E Greenberg, JE Bradner, O Wiest Bioorganic & medicinal chemistry 18 (11), 4103-4110, 2010 | 94 | 2010 |
Electrocatalytic reduction of CO2 by aza-macrocyclic complexes of Ni (II), Co (II), and Cu (II). Theoretical contribution to probable mechanisms M Isaacs, JC Canales, MJ Aguirre, G Estiu, F Caruso, G Ferraudi, ... Inorganica chimica acta 339, 224-232, 2002 | 86 | 2002 |
Electronic, magnetic, and spectroscopic properties of binuclear diruthenium tetracarboxylates: a theoretical and experimental study G Estiú, FD Cukiernik, P Maldivi, O Poizat Inorganic Chemistry 38 (13), 3030-3039, 1999 | 78 | 1999 |
Characterization of the anticonvulsant profile of valpromide derivatives SM Tasso, SC Moon, LE Bruno-Blanch, GL Estiú Bioorganic & medicinal chemistry 12 (14), 3857-3869, 2004 | 74 | 2004 |
Competitive hydrolytic and elimination mechanisms in the urease catalyzed decomposition of urea G Estiu, KM Merz The Journal of Physical Chemistry B 111 (34), 10263-10274, 2007 | 73 | 2007 |
Residues in the 11 Å channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors SVW Weerasinghe, G Estiu, O Wiest, MKH Pflum Journal of medicinal chemistry 51 (18), 5542-5551, 2008 | 72 | 2008 |
A quantum chemical approach to the influence of platinum surface structure on the oxygen electroreduction reaction CF Zinola, AJ Arvia, GL Estiu, EA Castro The Journal of Physical Chemistry 98 (31), 7566-7576, 1994 | 70 | 1994 |
Enzymatic catalysis of urea decomposition: elimination or hydrolysis? G Estiu, KM Merz Journal of the American Chemical Society 126 (38), 11832-11842, 2004 | 68 | 2004 |
Quantum mechanical and molecular dynamics simulations of ureases and Zn β‐lactamases G Estiu, D Suárez, KM Merz Journal of computational chemistry 27 (12), 1240-1262, 2006 | 66 | 2006 |
Pharmacophore searching and QSAR analysis in the design of anticonvulsant drugs SM Tasso, LE Bruno-Blanch, SC Moon, GL Estiú Journal of molecular structure: THEOCHEM 504 (1-3), 229-240, 2000 | 62 | 2000 |