Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress RG al. Cell, 2014 | 472 | 2014 |
Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing SH Chiou, IP Winters, J Wang, S Naranjo, C Dudgeon, FB Tamburini, ... Genes & development 29 (14), 1576-1585, 2015 | 267 | 2015 |
The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome DR Caswell, C Swanton BMC medicine 15, 1-9, 2017 | 219 | 2017 |
Lung adenocarcinoma promotion by air pollutants W Hill, EL Lim, CE Weeden, C Lee, M Augustine, K Chen, FC Kuan, ... Nature 616 (7955), 159-167, 2023 | 199 | 2023 |
Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis CH Chuang, PG Greenside, ZN Rogers, JJ Brady, D Yang, RK Ma, ... Nature medicine 23 (3), 291-300, 2017 | 152 | 2017 |
An Arntl2-driven secretome enables lung adenocarcinoma metastatic self-sufficiency JJ Brady, CH Chuang, PG Greenside, ZN Rogers, CW Murray, ... Cancer cell 29 (5), 697-710, 2016 | 93 | 2016 |
The neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis S KW, K C, B KJ, L Jaewon, L AN, L KT, Z P, B AM, F CM, C DR, et al. PNAS, 2014 | 90* | 2014 |
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution S Venkatesan, M Angelova, C Puttick, H Zhai, DR Caswell, WT Lu, ... Cancer discovery 11 (10), 2456-2473, 2021 | 87 | 2021 |
Obligate progression precedes lung adenocarcinoma dissemination DR Caswell, CH Chuang, D Yang, SH Chiou, S Cheemalavagu, ... Cancer discovery 4 (7), 781-789, 2014 | 56 | 2014 |
Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma PN Valdmanis, B Roy-Chaudhuri, HK Kim, LC Sayles, Y Zheng, ... Oncogene 34 (1), 94-103, 2015 | 53 | 2015 |
Tumor Suppressor Activity of Selenbp1, a Direct Nkx2-1 Target, Suppresses Lung Cancer DR Caswell, CH Chuang, RK Ma, IP Winters, EL Snyder, MM Winslow Molecular Cancer Research 16 (11), 1737-1749, 2018 | 35* | 2018 |
An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations J Boumelha, S de Carné Trécesson, EK Law, P Romero-Clavijo, ... Cancer research 82 (19), 3435-3448, 2022 | 30 | 2022 |
Capturing cancer evolution using genetically engineered mouse models (GEMMs) W Hill, DR Caswell, C Swanton Trends in Cell Biology 31 (12), 1007-1018, 2021 | 24 | 2021 |
Targeted cancer therapy induces APOBEC fueling the evolution of drug resistance M Mayekar, D Caswell, N Vokes, EK Law, W Wu, W Hill, E Gronroos, ... Cancer Research 82 (12_Supplement), 2197-2197, 2022 | 18 | 2022 |
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance DR Caswell, P Gui, MK Mayekar, EK Law, O Pich, C Bailey, J Boumelha, ... Nature Genetics 56 (1), 60-73, 2024 | 11 | 2024 |
APOBEC3B expression generates an immunogenic model of Kras mutant lung cancer S de Carné Trécesson, J Boumelha, EK Law, P Romero-Clavijo, ... BioRxiv, 2020.2012. 2022.423126, 2020 | 6 | 2020 |
Non-Small-Cell Lung Cancer Promotion by Air Pollutants C Swanton, W Hill, E Lim, C Lee, C Weeden, M Augustine, K Chen, ... | 3 | 2022 |
Tumor heterogeneity impairs immunogenicity in mismatch repair deficient tumors JL Reading, DR Caswell, C Swanton Nature Genetics 55 (10), 1610-1612, 2023 | 2 | 2023 |
The role of APOBEC3B in lung tumour evolution and targeted therapy resistance DR Caswell, MK Mayekar, P Gui, EK Law, NI Vokes, CM Ruiz, M Dietzen, ... bioRxiv, 2020.12. 18.423280, 2020 | 2 | 2020 |
An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations J Boumelha, S de Carné Trécesson, EK Law, P Romero-Clavijo, ... bioRxiv, 2020.12. 22.423126, 2020 | 1 | 2020 |