Goran Malojcic, PhD
Goran Malojcic, PhD
Harvard University
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LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface
G Malojčić, D Andres, M Grabowicz, AH George, N Ruiz, TJ Silhavy, ...
Proceedings of the National Academy of Sciences 111 (26), 9467-9472, 2014
DsbL and DsbI form a specific dithiol oxidase system for periplasmic arylsulfate sulfotransferase in uropathogenic Escherichia coli
JPA Grimshaw, CU Stirnimann, MS Brozzo, G Malojcic, MG Grütter, ...
Journal of molecular biology 380 (4), 667-680, 2008
Structural basis of substrate specificity of human oligosaccharyl transferase subunit N33/Tusc3 and its role in regulating protein N-glycosylation
E Mohorko, RL Owen, G Malojčić, MS Brozzo, M Aebi, R Glockshuber
Structure 22 (4), 590-601, 2014
A Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa
G Andolina, LC Bencze, K Zerbe, M Müller, J Steinmann, H Kocherla, ...
ACS chemical biology 13 (3), 666-675, 2018
A novel bis-phenanthridine triamine with pH controlled binding to nucleotides and nucleic acids
G Malojčić, I Piantanida, M Marinić, M Žinić, M Marjanović, M Kralj, ...
Organic & Biomolecular Chemistry 3 (24), 4373-4381, 2005
A structural and biochemical basis for PAPS-independent sulfuryl transfer by aryl sulfotransferase from uropathogenic Escherichia coli
G Malojčić, RL Owen, JPA Grimshaw, MS Brozzo, H Dreher-Teo, ...
Proceedings of the National Academy of Sciences 105 (49), 19217-19222, 2008
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription
JK Rimel, ZC Poss, B Erickson, ZL Maas, CC Ebmeier, JL Johnson, ...
Genes & development 34 (21-22), 1452-1473, 2020
Oxidative folding of peptides and proteins
L Moroder, J Buchner
Royal society of chemistry, 2009
Structural basis of TRPC4 regulation by calmodulin and pharmacological agents
D Vinayagam, D Quentin, J Yu-Strzelczyk, O Sitsel, F Merino, M Stabrin, ...
Elife 9, e60603, 2020
Preparation and structure of the charge-transfer intermediate of the transmembrane redox catalyst DsbB
G Malojčić, RL Owen, JPA Grimshaw, R Glockshuber
FEBS letters 582 (23-24), 3301-3307, 2008
The PAPS-independent aryl sulfotransferase and the alternative disulfide bond formation system in pathogenic bacteria
G Malojčić, R Glockshuber
Antioxidants & redox signaling 13 (8), 1247-1259, 2010
Discovery of SY-5609: a selective, noncovalent inhibitor of CDK7
JJ Marineau, KB Hamman, S Hu, S Alnemy, J Mihalich, A Kabro, ...
Journal of Medicinal Chemistry 65 (2), 1458-1480, 2021
Discovery of a potent and selective TRPC5 inhibitor, efficacious in a focal segmental glomerulosclerosis model
M Yu, MW Ledeboer, M Daniels, G Malojcic, TT Tibbitts, M Coeffet-Le Gal, ...
ACS Medicinal Chemistry Letters 10 (11), 1579-1585, 2019
A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface
M Grabowicz, D Andres, MD Lebar, G Malojčić, D Kahne, TJ Silhavy
Elife 3, e05334, 2014
Structural and mechanistic insights into the PAPS-independent sulfotransfer catalyzed by bacterial aryl sulfotransferase and the role of the DsbL/DsbI system in its folding
G Malojcic, RL Owen, R Glockshuber
Biochemistry 53 (11), 1870-1877, 2014
Transplanted organoids empower human preclinical assessment of drug candidate for the clinic
AD Westerling-Bui, EM Fast, TW Soare, S Venkatachalan, M DeRan, ...
Science Advances 8 (27), eabj5633, 2022
Discovery and optimization of highly selective inhibitors of CDK5
MH Daniels, G Malojcic, SL Clugston, B Williams, M Coeffet-Le Gal, ...
Journal of Medicinal Chemistry 65 (4), 3575-3596, 2022
A peptidomimetic antibiotic interacts with the periplasmic domain of LptD from Pseudomonas aeruginosa. ACS Chem Biol 13: 666–675
G Andolina, LC Bencze, K Zerbe, M Muller, J Steinmann, H Kocherla, ...
Mechanism of the prokaryotic transmembrane disulfide reduction pathway and its in vitro reconstitution from purified components
G Malojčić, ER Geertsma, MS Brozzo, R Glockshuber
Angewandte Chemie International Edition 51 (28), 6900-6903, 2012
A translational kidney organoid system bolsters human relevance of clinical development candidate
A Westerling-Bui, TW Soare, S Venkatachalan, M DeRan, EM Fast, ...
bioRxiv, 2019.12. 30.891440, 2019
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