Karen Gascoigne
Karen Gascoigne
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Cancer cells display profound intra-and interline variation following prolonged exposure to antimitotic drugs
KE Gascoigne, SS Taylor
Cancer cell 14 (2), 111-122, 2008
How do anti-mitotic drugs kill cancer cells?
KE Gascoigne, SS Taylor
Journal of cell science 122 (15), 2579-2585, 2009
Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes
KE Gascoigne, K Takeuchi, A Suzuki, T Hori, T Fukagawa, IM Cheeseman
Cell 145 (3), 410-422, 2011
Validating Aurora B as an anti-cancer drug target
F Girdler, KE Gascoigne, PA Eyers, S Hartmuth, C Crafter, KM Foote, ...
Journal of cell science 119 (17), 3664-3675, 2006
CENP-TWSX forms a unique centromeric chromatin structure with a histone-like fold
T Nishino, K Takeuchi, KE Gascoigne, A Suzuki, T Hori, T Oyama, ...
Cell 148 (3), 487-501, 2012
Enhancer activity requires CBP/P300 bromodomain-dependent histone H3K27 acetylation
R Raisner, S Kharbanda, L Jin, E Jeng, E Chan, M Merchant, PM Haverty, ...
Cell reports 24 (7), 1722-1729, 2018
Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T
F Rago, KE Gascoigne, IM Cheeseman
Current Biology 25 (5), 671-677, 2015
Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate CancerCBP/p300 Inhibitors for the Treatment of Prostate Cancer
L Jin, J Garcia, E Chan, C de la Cruz, E Segal, M Merchant, S Kharbanda, ...
Cancer research 77 (20), 5564-5575, 2017
Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma
AR Conery, RC Centore, A Neiss, PJ Keller, S Joshi, KL Spillane, ...
Elife 5, e10483, 2016
CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state
KE Gascoigne, IM Cheeseman
Journal of Cell Biology 201 (1), 23-32, 2013
Kinetochore assembly: if you build it, they will come
KE Gascoigne, IM Cheeseman
Current opinion in cell biology 23 (1), 102-108, 2011
Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity
TH Pillow, P Adhikari, RA Blake, J Chen, G Del Rosario, G Deshmukh, ...
ChemMedChem 15 (1), 17-25, 2020
Discovery of a potent and selective in vivo probe (GNE-272) for the bromodomains of CBP/EP300
TD Crawford, FA Romero, KW Lai, V Tsui, AM Taylor, G de Leon Boenig, ...
Journal of medicinal chemistry 59 (23), 10549-10563, 2016
GNE-781, a highly advanced potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein, binding protein (CBP)
FA Romero, J Murray, KW Lai, V Tsui, BK Albrecht, L An, MH Beresini, ...
Journal of Medicinal Chemistry 60 (22), 9162-9183, 2017
Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis
KE Gascoigne, IM Cheeseman
Chromosome Research 21, 407-418, 2013
The ETS domain transcription factor Elk-1 regulates the expression of its partner protein, SRF
A Kasza, A O'Donnell, K Gascoigne, LAH Zeef, A Hayes, AD Sharrocks
Journal of Biological Chemistry 280 (2), 1149-1155, 2005
Antibody-mediated delivery of chimeric BRD4 degraders. Part 1: exploration of antibody linker, payload loading, and payload molecular properties
PS Dragovich, TH Pillow, RA Blake, JD Sadowsky, E Adaligil, P Adhikari, ...
Journal of Medicinal Chemistry 64 (5), 2534-2575, 2021
Regulation of tumor-associated myeloid cell activity by CBP/EP300 bromodomain modulation of H3K27 acetylation
DE de Almeida Nagata, EY Chiang, S Jhunjhunwala, P Caplazi, ...
Cell Reports 27 (1), 269-281. e4, 2019
Repeated Sequences in CASPASE-5 and FANCD2 but not NF1 Are Targets for Mutation in Microsatellite-Unstable Acute Leukemia/Myelodysplastic Syndrome
J Offman, K Gascoigne, F Bristow, P Macpherson, M Bignami, I Casorelli, ...
Molecular cancer research 3 (5), 251-260, 2005
Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens
JP Fortin, J Tan, KE Gascoigne, PM Haverty, WF Forrest, MR Costa, ...
Genome biology 20, 1-25, 2019
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