Hans Zempel
Hans Zempel
Institute for Human Genetics, University Hospital Cologne, Germany
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Aβ oligomers cause localized Ca2+ elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
H Zempel, E Thies, E Mandelkow, EM Mandelkow
Journal of Neuroscience 30 (36), 11938-11950, 2010
Lost after translation: missorting of Tau protein and consequences for Alzheimer disease
H Zempel, E Mandelkow
Trends in neurosciences 37 (12), 721-732, 2014
Amyloid‐β oligomers induce synaptic damage via Tau‐dependent microtubule severing by TTLL6 and spastin
H Zempel, J Luedtke, Y Kumar, J Biernat, H Dawson, E Mandelkow, ...
The EMBO journal 32 (22), 2920-2937, 2013
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration
X Li, Y Kumar, H Zempel, EM Mandelkow, J Biernat, E Mandelkow
The EMBO journal 30 (23), 4825-4837, 2011
Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture
H Zempel, FJA Dennissen, Y Kumar, J Luedtke, J Biernat, EM Mandelkow, ...
Journal of Biological Chemistry 292 (29), 12192-12207, 2017
Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton
H Zempel, EM Mandelkow
Neurodegenerative Diseases 10 (1-4), 64-72, 2012
Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia
H Zempel, EM Mandelkow
Molecular neurodegeneration 10, 1-12, 2015
Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting
MP Schützmann, F Hasecke, S Bachmann, M Zielinski, S Hänsch, ...
Nature communications 12 (1), 4634, 2021
Differential effects of the six human TAU isoforms: somatic retention of 2N-TAU and increased microtubule number induced by 4R-TAU
S Bachmann, M Bell, J Klimek, H Zempel
Frontiers in Neuroscience 15, 643115, 2021
SH-SY5Y-derived neurons: A human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability
M Bell, H Zempel
Reviews in the Neurosciences 33 (1), 1-15, 2022
Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging …
T Timm, JP von Kries, X Li, H Zempel, E Mandelkow, EM Mandelkow
Journal of Biological Chemistry 286 (48), 41711-41722, 2011
Mechanisms of axonal sorting of tau and influence of the axon initial segment on tau cell polarity
H Zempel, E Mandelkow
Tau Biology, 69-77, 2019
Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS
M Bell, S Bachmann, J Klimek, F Langerscheidt, H Zempel
Neuroscience 461, 155-171, 2021
DNA methylation in genetic and sporadic forms of neurodegeneration: lessons from Alzheimer’s, related tauopathies and genetic tauopathies
G Zimmer-Bensch, H Zempel
Cells 10 (11), 3064, 2021
Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes
Y Miura, Y Sakurai, M Hayakawa, Y Shimada, H Zempel, Y Sato, ...
Biological and Pharmaceutical Bulletin 33 (1), 22-28, 2010
DNA Methyltransferase 1 (DNMT1) shapes neuronal activity of human iPSC-derived glutamatergic cortical neurons
S Bachmann, J Linde, M Bell, M Spehr, H Zempel, G Zimmer-Bensch
International Journal of Molecular Sciences 22 (4), 2034, 2021
Tracking Tau in neurons: How to grow, fix, and stain primary neurons for the investigation of Tau in all developmental stages
H Zempel, EM Mandelkow
Tau Protein: Methods and Protocols, 327-334, 2017
A mitochondria cluster at the proximal axon initial segment controls axodendritic TAU trafficking in rodent primary and human iPSC-derived neurons
N Tjiang, H Zempel
Cellular and Molecular Life Sciences 79 (2), 120, 2022
Microtubule affinity regulating kinase (MARK/Par1) isoforms differentially regulate Alzheimer-like TAU missorting and Aβ-mediated synapse pathology
J Chudobová, H Zempel
Neural Regeneration Research 18 (2), 335-336, 2023
A simple human cell model for TAU trafficking and tauopathy-related TAU pathology
M Bell, H Zempel
Neural Regeneration Research 17 (4), 770-772, 2022
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