Eamon F X Byrne

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Christian SieboldProfessor of Structural BiologyVerified email at strubi.ox.ac.uk
Giovanni LuchettiPrincipal Scientist Discovery Oncology Genentech Inc.Verified email at gene.com
Mark S.P. SansomUniversity of OxfordVerified email at bioch.ox.ac.uk
Douglas CoveyProfessor Pharmacology, Washington UniversityVerified email at wustl.edu
Ria Sircar23andMe, Inc.Verified email at 23andme.com
Sigrid NachtergaeleAssistant Professor, Yale UniversityVerified email at yale.edu
Simon NewsteadUniversity of OxfordVerified email at bioch.ox.ac.uk
George HedgerVertex Pharmaceuticals, D. E. Shaw Research, University of OxfordVerified email at vrtx.com
Paul MillerUniversity of CambridgeVerified email at cam.ac.uk
Jennifer KongStanford UniversityVerified email at stanford.edu
David R. Raleigh, MD, PhDUniversity of California San FranciscoVerified email at ucsf.edu
Matthew CallWalter and Eliza Hall Institute of Medical ResearchVerified email at wehi.edu.au
Melissa CallWalter and Eliza Hall Institute of Medical ResearchVerified email at wehi.edu.au
Logesvaran KrshnanPostdoctoral Research Associate, MRC Protein Phosphorylation and Ubiquitylation UnitVerified email at dundee.ac.uk
Yoon Seok KimDepartment of Bioengineering, Stanford UniversityVerified email at stanford.edu
Hideaki E. KatoThe University of TokyoVerified email at g.ecc.u-tokyo.ac.jp
Karl DeisserothBioengineering and Psychiatry, Stanford UniversityVerified email at stanford.edu

Eamon F X Byrne

Department of Bioengineering, Stanford University

Verified email at stanford.edu

structural biology membrane proteins bioengineering ion channels neuroscience


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Structural basis of Smoothened regulation by its extracellular domains EFX Byrne, R Sircar, PS Miller, G Hedger, G Luchetti, S Nachtergaele, ... Nature 535 (7613), 517-522, 2016	354	2016
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling G Luchetti, R Sircar, JH Kong, S Nachtergaele, A Sagner, EFX Byrne, ... Elife 5, e20304, 2016	227	2016
Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins J Elegheert, E Behiels, B Bishop, S Scott, RE Woolley, SC Griffiths, ... Nature protocols 13 (12), 2991-3017, 2018	174	2018
Cilia-associated oxysterols activate smoothened DR Raleigh, N Sever, PK Choksi, MA Sigg, KM Hines, BM Thompson, ... Molecular cell 72 (2), 316-327. e5, 2018	113	2018
Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine KE Kishi, YS Kim, M Fukuda, M Inoue, T Kusakizako, PY Wang, ... Cell 185 (4), 672-689. e23, 2022	85	2022
Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates EFX Byrne, G Luchetti, R Rohatgi, C Siebold Current opinion in cell biology 51, 81-88, 2018	67	2018
Structure, mechanism, and inhibition of Hedgehog acyltransferase CE Coupland, SA Andrei, TB Ansell, L Carrique, P Kumar, L Sefer, ... Molecular cell 81 (24), 5025-5038. e10, 2021	34	2021
Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain M Kinnebrew, RE Woolley, TB Ansell, EFX Byrne, S Frigui, G Luchetti, ... Science Advances 8 (22), eabm5563, 2022	20	2022
Structural basis for ion selectivity in potassium-selective channelrhodopsins S Tajima, YS Kim, M Fukuda, YJ Jo, PY Wang, JM Paggi, M Inoue, ... Cell 186 (20), 4325-4344. e26, 2023	11	2023
Production of disulfide-stabilized transmembrane peptide complexes for structural studies P Sharma, M Kaywan-Lutfi, L Krshnan, EFX Byrne, MJ Call, ME Call JoVE (Journal of Visualized Experiments), e50141, 2013	8	2013
A serine in the first transmembrane domain of the human E3 ubiquitin ligase MARCH9 is critical for down-regulation of its protein substrates C Tan, EFX Byrne, C Ah-Cann, MJ Call, ME Call Journal of Biological Chemistry 294 (7), 2470-2485, 2019	7	2019
SURPAS Long Range Planning Report 2023 E Byrne, TMG MacKenzie, S Suresh, MU Ahmad OSF Preprints, 2023		2023
Molecular mechanisms of hedgehog signal transduction by the G-protein coupled receptor smoothened E Byrne University of Oxford, 2017		2017

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