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Dilshan S. Harischandra
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Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease
S Sarkar, E Malovic, DS Harishchandra, S Ghaisas, N Panicker, A Charli, ...
npj Parkinson's Disease 3 (1), 30, 2017
2182017
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
N Panicker, S Sarkar, DS Harischandra, M Neal, TI Kam, H Jin, ...
Journal of Experimental Medicine 216 (6), 1411-1430, 2019
1942019
Manganese-induced neurotoxicity: new insights into the triad of protein misfolding, mitochondrial impairment, and neuroinflammation
DS Harischandra, S Ghaisas, G Zenitsky, H Jin, A Kanthasamy, ...
Frontiers in Neuroscience 13, 654, 2019
1862019
Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of Parkinson's disease
N Panicker, H Saminathan, H Jin, M Neal, DS Harischandra, R Gordon, ...
Journal of Neuroscience 35 (27), 10058-10077, 2015
1482015
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
DS Harischandra, D Rokad, ML Neal, S Ghaisas, S Manne, S Sarkar, ...
Science signaling 12 (572), eaau4543, 2019
1452019
Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes
S Sarkar, E Malovic, DS Harischandra, HA Ngwa, A Ghosh, C Hogan, ...
Neurotoxicology 64, 204-218, 2018
1212018
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
S Sarkar, D Rokad, E Malovic, J Luo, DS Harischandra, H Jin, ...
Science Signaling 12 (563), eaat9900, 2019
1152019
Prokineticin‐2 promotes chemotaxis and alternative A2 reactivity of astrocytes
M Neal, J Luo, DS Harischandra, R Gordon, S Sarkar, H Jin, ...
Glia 66 (10), 2137-2157, 2018
1012018
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease
R Gordon, N Singh, V Lawana, A Ghosh, DS Harischandra, H Jin, ...
Neurobiology of disease 93, 96-114, 2016
982016
Mitoapocynin treatment protects against neuroinflammation and dopaminergic neurodegeneration in a preclinical animal model of Parkinson’s disease
A Ghosh, MR Langley, DS Harischandra, ML Neal, H Jin, V Anantharam, ...
Journal of Neuroimmune Pharmacology 11, 259-278, 2016
952016
α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson’s disease
DS Harischandra, H Jin, V Anantharam, A Kanthasamy, AG Kanthasamy
Toxicological Sciences 143 (2), 454-468, 2015
952015
The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease
A Ghosh, H Saminathan, A Kanthasamy, V Anantharam, H Jin, ...
Journal of Biological Chemistry 288 (30), 21955-21971, 2013
912013
Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy
TM Brenza, S Ghaisas, JEV Ramirez, D Harischandra, V Anantharam, ...
Nanomedicine: Nanotechnology, biology and medicine 13 (3), 809-820, 2017
882017
Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
R Gordon, ML Neal, J Luo, MR Langley, DS Harischandra, N Panicker, ...
Nature communications 7 (1), 12932, 2016
882016
Kv1. 3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease
S Sarkar, HM Nguyen, E Malovic, J Luo, M Langley, BN Palanisamy, ...
The Journal of clinical investigation 130 (8), 4195-4212, 2020
872020
Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal …
DS Harischandra, S Ghaisas, D Rokad, M Zamanian, H Jin, ...
Neurotoxicology 64, 267-277, 2018
822018
Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease
H Jin, A Kanthasamy, DS Harischandra, N Kondru, A Ghosh, N Panicker, ...
Journal of Biological Chemistry 289 (50), 34743-34767, 2014
812014
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation
D Rokad, S Ghaisas, DS Harischandra, H Jin, V Anantharam, ...
Brain research bulletin 133, 60-70, 2017
562017
Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity
CF Yen, DS Harischandra, A Kanthasamy, S Sivasankar
Science advances 2 (7), e1600014, 2016
492016
Exosomes in toxicology: relevance to chemical exposure and pathogenesis of environmentally linked diseases
DS Harischandra, S Ghaisas, D Rokad, AG Kanthasamy
Toxicological Sciences 158 (1), 3-13, 2017
452017
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