Prati Fabio
Prati Fabio
Professor of Organic Chemistry
Verified email at
Cited by
Cited by
Nanomolar inhibitors of AmpC β-lactamase
F Morandi, E Caselli, S Morandi, PJ Focia, J Blázquez, BK Shoichet, ...
Journal of the American Chemical Society 125 (3), 685-695, 2003
A Mild Synthesis of Vinyl Halides and gem-Dihalides Using Triphenyl Phosphite−Halogen-Based Reagents
A Spaggiari, D Vaccari, P Davoli, G Torre, F Prati
The Journal of organic chemistry 72 (6), 2216-2219, 2007
Structures of Ceftazidime and Its Transition-State Analogue in Complex with AmpC β-Lactamase:  Implications for Resistance Mutations and Inhibitor Design,
RA Powers, E Caselli, PJ Focia, F Prati, BK Shoichet
Biochemistry 40 (31), 9207-9214, 2001
Negative epistasis and evolvability in TEM-1 β-lactamase—the thin line between an enzyme's conformational freedom and disorder
E Dellus-Gur, M Elias, E Caselli, F Prati, MLM Salverda, JAGM De Visser, ...
Journal of molecular biology 427 (14), 2396-2409, 2015
The deacylation mechanism of AmpC β-lactamase at ultrahigh resolution
Y Chen, G Minasov, TA Roth, F Prati, BK Shoichet
Journal of the American Chemical Society 128 (9), 2970-2976, 2006
Energetic, structural, and antimicrobial analyses of β-lactam side chain recognition by β-lactamases
E Caselli, RA Powers, LC Blasczcak, CYE Wu, F Prati, BK Shoichet
Chemistry & biology 8 (1), 17-31, 2001
Carbonylation of silylated hydroxymethyl aziridines to β-lactams
P Davoli, I Moretti, F Prati, H Alper
The Journal of Organic Chemistry 64 (2), 518-521, 1999
Design, synthesis, crystal structures, and antimicrobial activity of sulfonamide boronic acids as β-lactamase inhibitors
O Eidam, C Romagnoli, E Caselli, K Babaoglu, DT Pohlhaus, J Karpiak, ...
Journal of medicinal chemistry 53 (21), 7852-7863, 2010
On the effect of ring substituents in the carbonylation of aziridines
P Davoli, A Forni, I Moretti, F Prati, G Torre
Tetrahedron 57 (9), 1801-1812, 2001
Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria
A Cougnoux, J Delmas, L Gibold, T Faïs, C Romagnoli, F Robin, ...
Gut 65 (2), 278-285, 2016
Structure-based optimization of cephalothin-analogue boronic acids as β-lactamase inhibitors
S Morandi, F Morandi, E Caselli, BK Shoichet, F Prati
Bioorganic & medicinal chemistry 16 (3), 1195-1205, 2008
Fragment-guided design of subnanomolar β-lactamase inhibitors active in vivo
O Eidam, C Romagnoli, G Dalmasso, S Barelier, E Caselli, R Bonnet, ...
Proceedings of the National Academy of Sciences 109 (43), 17448-17453, 2012
Ligand-induced proton transfer and low-barrier hydrogen bond revealed by X-ray crystallography
DA Nichols, JC Hargis, R Sanishvili, P Jaishankar, K Defrees, EW Smith, ...
Journal of the American Chemical Society 137 (25), 8086-8095, 2015
Structure and dynamics of CTX-M enzymes reveal insights into substrate accommodation by extended-spectrum β-lactamases
J Delmas, Y Chen, F Prati, F Robin, BK Shoichet, R Bonnet
Journal of molecular biology 375 (1), 192-201, 2008
Recognition and resistance in TEM β-lactamase
X Wang, G Minasov, J Blázquez, E Caselli, F Prati, BK Shoichet
Biochemistry 42 (28), 8434-8444, 2003
Nanomolar β-lactamase inhibitors
BK Shoichet, F Prati
US Patent 7,271,186, 2007
Probing active site chemistry in SHV β-lactamase variants at Ambler position 244: understanding unique properties of inhibitor resistance
JM Thomson, AM Distler, F Prati, RA Bonomo
Journal of Biological Chemistry 281 (36), 26734-26744, 2006
Deciphering the evolution of cephalosporin resistance to ceftolozane-tazobactam in Pseudomonas aeruginosa
MD Barnes, MA Taracila, JD Rutter, CR Bethel, I Galdadas, AM Hujer, ...
MBio 9 (6), 10.1128/mbio. 02085-18, 2018
Boronic acid transition state inhibitors active against KPC and other class A β-lactamases: structure-activity relationships as a guide to inhibitor design
LJ Rojas, MA Taracila, KM Papp-Wallace, CR Bethel, E Caselli, ...
Antimicrobial Agents and Chemotherapy 60 (3), 1751-1759, 2016
Total synthesis of (−)-microcarpalide, a novel microfilament disrupting metabolite
P Davoli, A Spaggiari, L Castagnetti, F Prati
Organic & biomolecular chemistry 2 (1), 38-47, 2004
The system can't perform the operation now. Try again later.
Articles 1–20