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David R. Snead
David R. Snead
Director, Chemical Process Research and Development
Verified email at mirati.com
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Cited by
Cited by
Year
On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
A Adamo, RL Beingessner, M Behnam, J Chen, TF Jamison, KF Jensen, ...
Science 352 (6281), 61-67, 2016
10092016
A three‐minute synthesis and purification of ibuprofen: Pushing the limits of continuous‐flow processing
DR Snead, TF Jamison
Angewandte Chemie International Edition 54 (3), 983-987, 2015
2492015
End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts
DR Snead, TF Jamison
Chemical Science 4 (7), 2822-2827, 2013
1132013
Recent developments of chiral diaminocarbene-metal complexes for asymmetric catalysis
DR Snead, H Seo, S Hong
Current Organic Chemistry 12 (16), 1370-1387, 2008
692008
Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant
M Berton, JM de Souza, I Abdiaj, DT McQuade, DR Snead
Journal of Flow Chemistry 10, 73-92, 2020
672020
Bis (2-alkylpyrrolidin-1-yl) methylidenes as chiral acyclic diaminocarbene ligands
DR Snead, S Inagaki, KA Abboud, S Hong
Organometallics 29 (7), 1729-1739, 2010
552010
A concise route to MK-4482 (EIDD-2801) from cytidine
N Vasudevan, GP Ahlqvist, CP McGeough, DJ Paymode, FSP Cardoso, ...
Chemical Communications 56 (87), 13363-13364, 2020
542020
Continuous-flow synthesis and purification of atropine with sequential in-line separations of structurally similar impurities
C Dai, DR Snead, P Zhang, TF Jamison
Journal of Flow Chemistry 5 (3), 133-138, 2015
482015
Progress toward a large-scale synthesis of molnupiravir (MK-4482, EIDD-2801) from cytidine
GP Ahlqvist, CP McGeough, C Senanayake, JD Armstrong, A Yadaw, ...
ACS omega 6 (15), 10396-10402, 2021
462021
A new route to acyclic diaminocarbenes via lithium− halogen exchange
DR Snead, I Ghiviriga, KA Abboud, S Hong
Organic Letters 11 (15), 3274-3277, 2009
462009
Toward a practical, two-step process for molnupiravir: Direct hydroxamination of cytidine followed by selective esterification
DJ Paymode, N Vasudevan, S Ahmad, AL Kadam, FSP Cardoso, ...
Organic Process Research & Development 25 (8), 1822-1830, 2021
382021
Expanding access to remdesivir via an improved pyrrolotriazine synthesis: supply centered synthesis
DJ Paymode, FSP Cardoso, T Agrawal, JW Tomlin, DW Cook, JM Burns, ...
Organic Letters 22 (19), 7656-7661, 2020
362020
A high‐yielding synthesis of EIDD‐2801 from Uridine
A Steiner, D Znidar, SB Ötvös, DR Snead, D Dallinger, CO Kappe
European Journal of Organic Chemistry 2020 (43), 6736-6739, 2020
342020
A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2
V Gopalsamuthiram, C Williams, J Noble, TF Jamison, BF Gupton, ...
Synlett 32 (03), 326-328, 2021
332021
Bulky acyclic aminooxycarbene ligands
H Seo, DR Snead, KA Abboud, S Hong
Organometallics 30 (21), 5725-5730, 2011
332011
An efficient synthesis of tenofovir (PMPA): a key intermediate leading to tenofovir-based HIV medicines
BP Derstine, JW Tomlin, CL Peck, JP Dietz, BT Herrera, FSP Cardoso, ...
Organic Process Research & Development 24 (8), 1420-1427, 2020
202020
In situ generation of novel acyclic diaminocarbene–copper complex
D Hirsch-Weil, DR Snead, S Inagaki, H Seo, KA Abboud, S Hong
Chemical communications, 2475-2477, 2009
202009
One-step synthesis of 2-fluoroadenine using hydrogen fluoride pyridine in a continuous flow operation
N Salehi Marzijarani, DR Snead, JP McMullen, F Lévesque, M Weisel, ...
Organic Process Research & Development 23 (8), 1522-1528, 2019
162019
An economical route to lamivudine featuring a novel strategy for stereospecific assembly
DR Snead, DT McQuade, S Ahmad, R Krack, RW Stringham, JM Burns, ...
Organic Process Research & Development 24 (6), 1194-1198, 2020
152020
Developing an atroposelective dynamic kinetic resolution of MRTX1719 by resolving incompatible chemical operations
MM Achmatowicz, C Chen, DR Snead
Chemical Communications 58 (74), 10365-10367, 2022
142022
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