Nigel Scrutton
Nigel Scrutton
Professor of Enzymology, Manchester Institute of Biotechnology (MIB) and School of Chemistry
Adresă de e-mail confirmată pe manchester.ac.uk - Pagina de pornire
Citat de
Citat de
Redesign of the coenzyme specificity of a dehydrogenase by protein engineering
NS Scrutton, A Berry, RN Perham
Nature 343 (6253), 38-43, 1990
Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades
FG Mutti, T Knaus, NS Scrutton, M Breuer, NJ Turner
Science 349 (6255), 1525-1529, 2015
Atomic description of an enzyme reaction dominated by proton tunneling
L Masgrau, A Roujeinikova, LO Johannissen, P Hothi, J Basran, ...
Science 312 (5771), 237-241, 2006
Biocatalytic reductions and chemical versatility of the old yellow enzyme family of flavoprotein oxidoreductases
HS Toogood, JM Gardiner, NS Scrutton
ChemCatChem 2 (8), 892-914, 2010
Cation-π bonding and amino-aromatic interactions in the biomolecular recognition of substituted ammonium ligands
NS Scrutton, ARC Raine
Biochemical Journal 319 (1), 1-8, 1996
Good vibrations in enzyme-catalysed reactions
S Hay, NS Scrutton
Nature chemistry 4 (3), 161-168, 2012
Enzymatic H-transfer requires vibration-driven extreme tunneling
J Basran, MJ Sutcliffe, NS Scrutton
Biochemistry 38 (10), 3218-3222, 1999
Building a global alliance of biofoundries
N Hillson, M Caddick, Y Cai, JA Carrasco, MW Chang, NC Curach, ...
Nature communications 10 (1), 2040, 2019
Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: the current state of affairs
M Mewies, WS McIntire, NS Scrutton
Protein Science 7 (1), 7-20, 1998
Discovery, characterization, engineering, and applications of ene-reductases for industrial biocatalysis
HS Toogood, NS Scrutton
ACS catalysis 8 (4), 3532-3549, 2018
Biotransformation of explosives by the old yellow enzyme family of flavoproteins
RE Williams, DA Rathbone, NS Scrutton, NC Bruce
Applied and environmental microbiology 70 (6), 3566-3574, 2004
New cofactor supports α, β-unsaturated acid decarboxylation via 1, 3-dipolar cycloaddition
KAP Payne, MD White, K Fisher, B Khara, SS Bailey, D Parker, ...
Nature 522 (7557), 497-501, 2015
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals
P Carbonell, AJ Jervis, CJ Robinson, C Yan, M Dunstan, N Swainston, ...
Communications biology 1 (1), 66, 2018
What’s in a covalent bond? On the role and formation of covalently bound flavin cofactors
DPHM Heuts, NS Scrutton, WS McIntire, MW Fraaije
The FEBS journal 276 (13), 3405-3427, 2009
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis
MD White, KAP Payne, K Fisher, SA Marshall, D Parker, NJW Rattray, ...
Nature 522 (7557), 502-506, 2015
Better than nature: nicotinamide biomimetics that outperform natural coenzymes
T Knaus, CE Paul, CW Levy, S De Vries, FG Mutti, F Hollmann, ...
Journal of the American Chemical Society 138 (3), 1033-1039, 2016
A new conceptual framework for enzyme catalysis: Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes
MJ Sutcliffe, NS Scrutton
European Journal of Biochemistry 269 (13), 3096-3102, 2002
Biodiversity of cytochrome P450 redox systems
KJ McLean, M Sabri, KR Marshall, RJ Lawson, DG Lewis, D Clift, ...
Biochemical Society Transactions 33 (4), 796-801, 2005
The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase
R Neeli, HM Girvan, A Lawrence, MJ Warren, D Leys, NS Scrutton, ...
FEBS letters 579 (25), 5582-5588, 2005
New developments in ‘ene’-reductase catalysed biological hydrogenations
HS Toogood, NS Scrutton
Current opinion in chemical biology 19, 107-115, 2014
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