‪Philip Tsichlis or Philip N Tsichlis‬

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Tung Chanthomas jefferson universityVerified email at jefferson.edu
DIMITRIOS ILIOPOULOSUCLAVerified email at mednet.ucla.edu
Christos TsatsanisUniversity of Crete, Medical School, and IMBB-Foundation for Research and Technology HellasVerified email at med.uoc.gr
Thomas FrankeColumbia UniversityVerified email at columbia.edu
Kevin StruhlProfessor, Harvard Medical SchoolVerified email at hms.harvard.edu
Aristides EliopoulosNational and Kapodistrian University of AthensVerified email at med.uoa.gr
Sotirios C. KampranisProfessor of Biochemical Engineering, University of CopenhagenVerified email at plen.ku.dk
Ioannis SanidasPrincipal Investigator, Massachusetts General HospitalVerified email at mgh.harvard.edu
David R. KaplanHospital for Sick ChildrenVerified email at sickkids.ca
Mark DonowitzProfessor of Medicine and Physiology, Johns Hopkins University School of MedicineVerified email at jhmi.edu
Carlo CroceProfessor, Ohio State UniversityVerified email at osumc.edu
Alfredo FuscoProfessore di Patologia GeneraleVerified email at unina.it
Philip W. HindsTufts University School of MedicineVerified email at tufts.edu
C. Blake GilksUniversity of British ColumbiaVerified email at vch.ca
Neal RosenProfessor of Pharmacology, Memorial Sloan-Kettering Cancer CenterVerified email at mskcc.org
Rosa Marina MelilloProfessore del Dipartimento di Medicina Molecolare e Biotecnologie Mediche UNINAVerified email at unina.it
STEVE LEYUniversity College LondonVerified email at ucl.ac.uk
Giuseppe VigliettoProfessor of General Pathology, University Magna GraeciaVerified email at unicz.it
Nissim HayVerified email at uic.edu
Patrick A. Zweidler-McKay MD/PhDExecutive Medical Director, AbbVieVerified email at immunogen.com

Philip Tsichlis or Philip N Tsichlis

Professor of Cancer Biology and Genetics, Ohio State University

Verified email at osumc.edu

Cancer Biology Signaling Genetics and Epigenetics


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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase TF Franke, SI Yang, TO Chan, K Datta, A Kazlauskas, DK Morrison, ... Cell 81 (5), 727-736, 1995	2624	1995
A Retroviral Oncogene, akt, Encoding a Serine-Threonine Kinase Containing an SH2-Like Region A Bellacosa, JR Testa, SP Staal, PN Tsichlis Science 254 (5029), 274-277, 1991	1372	1991
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. SG Kennedy, AJ Wagner, SD Conzen, J Jordan, A Bellacosa, PN Tsichlis, ... Genes & development 11 (6), 701-713, 1997	1365	1997
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission HA Hirsch, D Iliopoulos, PN Tsichlis, K Struhl Cancer research 69 (19), 7507-7511, 2009	1352	2009
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation TO Chan, SE Rittenhouse, PN Tsichlis Annual review of biochemistry 68 (1), 965-1014, 1999	1296	1999
TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway CD Dumitru, JD Ceci, C Tsatsanis, D Kontoyiannis, K Stamatakis, JH Lin, ... Cell 103 (7), 1071-1083, 2000	1029	2000
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. JQ Cheng, AK Godwin, A Bellacosa, T Taguchi, TF Franke, TC Hamilton, ... Proceedings of the National Academy of Sciences 89 (19), 9267-9271, 1992	1006	1992
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27^Kip1 by PKB/Akt-mediated phosphorylation in breast cancer G Viglietto, ML Motti, P Bruni, RM Melillo, A D'alessio, D Califano, F Vinci, ... Nature medicine 8 (10), 1136-1144, 2002	896	2002
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines SJ Grille, A Bellacosa, J Upson, AJ Klein-Szanto, F Van Roy, W Lee-Kwon, ... Cancer research 63 (9), 2172-2178, 2003	850	2003
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway T Skorski, A Bellacosa, M Nieborowska‐Skorska, M Majewski, R Martinez, ... The EMBO journal, 1997	821	1997
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function AD Basso, DB Solit, G Chiosis, B Giri, P Tsichlis, N Rosen Journal of Biological Chemistry 277 (42), 39858-39866, 2002	779	2002
Akt activation by growth factors is a multiple-step process: the role of the PH domain A Bellacosa, TO Chan, NN Ahmed, K Datta, S Malstrom, D Stokoe, ... Oncogene 17 (3), 313-325, 1998	743	1998
Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway RC Muise-Helmericks, HL Grimes, A Bellacosa, SE Malstrom, PN Tsichlis, ... Journal of Biological Chemistry 273 (45), 29864-29872, 1998	685	1998
The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs A Androulidaki, D Iliopoulos, A Arranz, C Doxaki, S Schworer, ... Immunity 31 (2), 220-231, 2009	676	2009
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase NN Ahmed, HL Grimes, A Bellacosa, TO Chan, PN Tsichlis Proceedings of the National Academy of Sciences 94 (8), 3627-3632, 1997	663	1997
AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells M Sun, G Wang, JE Paciga, RI Feldman, ZQ Yuan, XL Ma, SA Shelley, ... The American journal of pathology 159 (2), 431-437, 2001	645	2001
Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation WG King, MD Mattaliano, TO Chan, PN Tsichlis, JS Brugge Molecular and cellular biology, 1997	570	1997
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization A Arranz, C Doxaki, E Vergadi, Y Martinez de la Torre, K Vaporidi, ... Proceedings of the National Academy of Sciences 109 (24), 9517-9522, 2012	544	2012
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase HW Chang, M Aoki, D Fruman, KR Auger, A Bellacosa, PN Tsichlis, ... Science 276 (5320), 1848-1850, 1997	536	1997
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation Y Pekarsky, A Koval, C Hallas, R Bichi, M Tresini, S Malstrom, G Russo, ... Proceedings of the National Academy of Sciences 97 (7), 3028-3033, 2000	491	2000

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