| Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes C Brännmark, E Nyman, S Fagerholm, L Bergenholm, EM Ekstrand, ... Journal of Biological Chemistry 288 (14), 9867-9880, 2013 | 140 | 2013 |
| A hierarchical whole-body modeling approach elucidates the link between in vitro insulin signaling and in vivo glucose homeostasis E Nyman, C Brännmark, R Palmér, J Brugård, FH Nyström, P Strålfors, ... Journal of Biological Chemistry 286 (29), 26028-26041, 2011 | 96 | 2011 |
| A single mechanism can explain network-wide insulin resistance in adipocytes from obese patients with type 2 diabetes E Nyman, MR Rajan, S Fagerholm, C Brännmark, G Cedersund, ... Journal of Biological Chemistry 289 (48), 33215-33230, 2014 | 59 | 2014 |
| Insulin signaling–mathematical modeling comes of age E Nyman, G Cedersund, P Strålfors Trends in Endocrinology & Metabolism 23 (3), 107-115, 2012 | 52 | 2012 |
| Systems-wide experimental and modeling analysis of insulin signaling through forkhead box protein O1 (FOXO1) in human adipocytes, normally and in type 2 diabetes MR Rajan, E Nyman, P Kjølhede, G Cedersund, P Strålfors Journal of Biological Chemistry 291 (30), 15806-15819, 2016 | 29 | 2016 |
| Model-based quantification of the systemic interplay between glucose and fatty acids in the postprandial state FLP Sips, E Nyman, M Adiels, PAJ Hilbers, P Strålfors, NAW van Riel, ... PloS One 10 (9), e0135665, 2015 | 22 | 2015 |
| Effects of IL‐1β–blocking therapies in type 2 diabetes mellitus: a quantitative systems pharmacology modeling approach to explore underlying mechanisms R Palmér, E Nyman, M Penney, A Marley, G Cedersund, B Agoram CPT: pharmacometrics & systems pharmacology 3 (6), 1-8, 2014 | 22 | 2014 |
| Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes E Nyman, YJW Rozendaal, G Helmlinger, B Hamrén, MC Kjellsson, ... Interface focus 6 (2), 20150075, 2016 | 20 | 2016 |
| Mathematical modeling improves EC50 estimations from classical dose–response curves E Nyman, I Lindgren, W Lövfors, K Lundengård, I Cervin, TA Sjöström, ... The FEBS Journal 282 (5), 951-962, 2015 | 19 | 2015 |
| Mechanistic explanations for counter‐intuitive phosphorylation dynamics of the insulin receptor and insulin receptor substrate‐1 in response to insulin in murine adipocytes E Nyman, S Fagerholm, D Jullesson, P Strålfors, G Cedersund The FEBS journal 279 (6), 987-999, 2012 | 19 | 2012 |
| Mathematical modeling of white adipocyte exocytosis predicts adiponectin secretion and quantifies the rates of vesicle exo-and endocytosis C Brännmark, W Lövfors, AM Komai, T Axelsson, MF El Hachmane, ... Journal of Biological Chemistry 292 (49), 20032-20043, 2017 | 16 | 2017 |
| Systems biology reveals uncoupling beyond UCP1 in human white fat-derived beige adipocytes E Nyman, S Bartesaghi, R Melin Rydfalk, S Eng, C Pollard, P Gennemark, ... NPJ systems biology and applications 3 (1), 29, 2017 | 16 | 2017 |
| A systems biology analysis connects insulin receptor signaling with glucose transporter translocation in rat adipocytes N Bergqvist, E Nyman, G Cedersund, KG Stenkula Journal of Biological Chemistry 292 (27), 11206-11217, 2017 | 14 | 2017 |
| Cross-talks via mTORC2 can explain enhanced activation in response to insulin in diabetic patients R Magnusson, M Gustafsson, G Cedersund, P Strålfors, E Nyman Bioscience reports 37 (1), BSR20160514, 2017 | 14 | 2017 |
| LASSIM—A network inference toolbox for genome-wide mechanistic modeling R Magnusson, GP Mariotti, M Köpsén, W Lövfors, DR Gawel, R Jörnsten, ... PLoS computational biology 13 (6), e1005608, 2017 | 11 | 2017 |
| Creating a bridge between modelica and the systems biology community J Brugård, D Hedberg, M Cascante, G Cedersund, À Gómez-Garrido, ... 7th International Modelica Conference, Como, Italy, 2009 | 9 | 2009 |
| Multilevel-Modeling, Core Predictions, and the Concept of Final Conclusions E Nyman, P Strålfors, G Cedersund Biosimulation in Biomedical Research, Health Care and Drug Development, 311-328, 2012 | 1 | 2012 |
| Insulin signaling dynamics in human adipocytes: Mathematical modeling reveals mechanisms of insulin resistance in type 2 diabetes E Nyman Linköping University Electronic Press, 2014 | | 2014 |
| Hierarchical modeling of diabetes: a pilot study E Nyman | | 2009 |
Gunnar CedersundAssociate Professor, Integrative Systems Biology, Dpt of Biomedical Engineering, LinköpingVerified email at liu.se
