| Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety WD Chey, AJ Lembo, BJ Lavins, SJ Shiff, CB Kurtz, MG Currie, ... Official journal of the American College of Gastroenterology| ACG 107 (11 …, 2012 | 508 | 2012 |
| Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria VM Isabella, BN Ha, MJ Castillo, DJ Lubkowicz, SE Rowe, YA Millet, ... Nature biotechnology 36 (9), 857-864, 2018 | 466 | 2018 |
| A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation S Rao, AJ Lembo, SJ Shiff, BJ Lavins, MG Currie, XD Jia, K Shi, ... Official journal of the American College of Gastroenterology| ACG 107 (11 …, 2012 | 424 | 2012 |
| Two randomized trials of linaclotide for chronic constipation AJ Lembo, HA Schneier, SJ Shiff, CB Kurtz, JE MacDougall, XD Jia, ... New England Journal of Medicine 365 (6), 527-536, 2011 | 415 | 2011 |
| An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans CB Kurtz, YA Millet, MK Puurunen, M Perreault, MR Charbonneau, ... Science translational medicine 11 (475), eaau7975, 2019 | 292 | 2019 |
| Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3′, 5′-monophosphate J Castro, AM Harrington, PA Hughes, CM Martin, P Ge, CM Shea, H Jin, ... Gastroenterology 145 (6), 1334-1346. e11, 2013 | 285 | 2013 |
| Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome V Andresen, M Camilleri, IA Busciglio, A Grudell, D Burton, S McKinzie, ... Gastroenterology 133 (3), 761-768, 2007 | 279 | 2007 |
| Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation JM Johnston, CB Kurtz, JE MacDougall, BJ Lavins, MG Currie, DA Fitch, ... Gastroenterology 139 (6), 1877-1886. e2, 2010 | 271 | 2010 |
| Developing a new class of engineered live bacterial therapeutics to treat human diseases MR Charbonneau, VM Isabella, N Li, CB Kurtz Nature Communications 11 (1), 1738, 2020 | 266 | 2020 |
| Efficacy of linaclotide for patients with chronic constipation AJ Lembo, CB Kurtz, JE MacDougall, BJ Lavins, MG Currie, DA Fitch, ... Gastroenterology 138 (3), 886-895. e1, 2010 | 262 | 2010 |
| Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit RW Busby, AP Bryant, WP Bartolini, EA Cordero, G Hannig, MM Kessler, ... European journal of pharmacology 649 (1-3), 328-335, 2010 | 226 | 2010 |
| Guanylate cyclase C‐mediated antinociceptive effects of linaclotide in rodent models of visceral pain H Eutamene, S Bradesi, M Larauche, V Theodorou, C Beaufrand, ... Neurogastroenterology & Motility 22 (3), 312-e84, 2010 | 202 | 2010 |
| Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract AP Bryant, RW Busby, WP Bartolini, EA Cordero, G Hannig, MM Kessler, ... Life sciences 86 (19-20), 760-765, 2010 | 200 | 2010 |
| The effect of psyllium husk on intestinal microbiota in constipated patients and healthy controls J Jalanka, G Major, K Murray, G Singh, A Nowak, C Kurtz, I Silos-Santiago, ... International journal of molecular sciences 20 (2), 433, 2019 | 179 | 2019 |
| Effects of products of activated leukocytes (lymphokines and monokines) on the growth of malignant trophoblast cells in vitro RS Berkowitz, JA Hill, CB Kurtz, DJ Anderson American Journal of Obstetrics and Gynecology 158 (1), 199-203, 1988 | 170 | 1988 |
| Apoptosis in acute and chronic central nervous system disease induced by Theiler's murine encephalomyelitis virus I Tsunoda, CIB Kurtz, RS Fujinami Virology 228 (2), 388-393, 1997 | 152 | 1997 |
| Pilot study on the effect of linaclotide in patients with chronic constipation JM Johnston, CB Kurtz, DA Drossman, AJ Lembo, BI Jeglinski, ... Official journal of the American College of Gastroenterology| ACG 104 (1 …, 2009 | 141 | 2009 |
| Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and … RW Busby, MM Kessler, WP Bartolini, AP Bryant, G Hannig, CS Higgins, ... Journal of Pharmacology and Experimental Therapeutics 344 (1), 196-206, 2013 | 140 | 2013 |
| GT160-246, a Toxin Binding Polymer for Treatment ofClostridium difficile Colitis CB Kurtz, EP Cannon, A Brezzani, M Pitruzzello, C Dinardo, E Rinard, ... Antimicrobial agents and chemotherapy 45 (8), 2340-2347, 2001 | 136 | 2001 |
| Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study MK Puurunen, J Vockley, SL Searle, SJ Sacharow, JA Phillips III, ... Nature Metabolism 3 (8), 1125-1132, 2021 | 98 | 2021 |
