Juan Valcarcel
Juan Valcarcel
ICREA Research Professor, Center for Genomic Regulation
Verified email at - Homepage
Cited by
Cited by
Alternative pre-mRNA splicing: the logic of combinatorial control
CWJ Smith, J Valcárcel
Trends in biochemical sciences 25 (8), 381-388, 2000
Alternative splicing and genome complexity
D Brett, H Pospisil, J Valcárcel, J Reich, P Bork
Nature genetics 30 (1), 29-30, 2002
Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins
R Singh, J Valcarcel, MR Green
Science 268 (5214), 1173-1176, 1995
Synonymous mutations frequently act as driver mutations in human cancers
F Supek, B Miñana, J Valcárcel, T Gabaldón, B Lehner
Cell 156 (6), 1324-1335, 2014
Nucleosome positioning as a determinant of exon recognition
H Tilgner, C Nikolaou, S Althammer, M Sammeth, M Beato, J Valcárcel, ...
Nature structural & molecular biology 16 (9), 996-1001, 2009
Roles and mechanisms of alternative splicing in cancer—implications for care
SC Bonnal, I López-Oreja, J Valcárcel
Nature reviews Clinical oncology 17 (8), 457-474, 2020
RNA-binding proteins in human genetic disease
F Gebauer, T Schwarzl, J Valcárcel, MW Hentze
Nature Reviews Genetics 22 (3), 185-198, 2021
The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA
J Valcárcel, R Singh, PD Zamore, MR Green
Nature 362 (6416), 171-175, 1993
The spliceosome as a target of novel antitumour drugs
S Bonnal, L Vigevani, J Valcárcel
Nature reviews Drug discovery 11 (11), 847-859, 2012
Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition
JM Izquierdo, N Majós, S Bonnal, C Martínez, R Castelo, R Guigó, ...
Molecular cell 19 (4), 475-484, 2005
Optimization of oligonucleotide-based DNA microarrays
A Relógio, C Schwager, A Richter, W Ansorge, J Valcárcel
Nucleic acids research 30 (11), e51-e51, 2002
Interaction of U2AF65 RS region with pre-mRNA of branch point and promotion base pairing with U2 snRNA
J Valcárcel, RK Gaur, R Singh, MR Green
Science 273 (5282), 1706-1709, 1996
Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3′ splice site AG
L Merendino, S Guth, D Bilbao, C Martínez, J Valcárcel
Nature 402 (6763), 838-841, 1999
RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation
EG Bechara, E Sebestyén, I Bernardis, E Eyras, J Valcárcel
Molecular cell 52 (5), 720-733, 2013
U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction.
J Fleckner, M Zhang, J Valcarcel, MR Green
Genes & development 11 (14), 1864-1872, 1997
The SR protein family: pleiotropic functions in pre-mRNA splicing
J Valcárcel, MR Green
Trends in biochemical sciences 21 (8), 296-301, 1996
The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing
P Förch, O Puig, N Kedersha, C Martínez, S Granneman, B Séraphin, ...
Molecular cell 6 (5), 1089-1098, 2000
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
A Corrionero, B Miñana, J Valcárcel
Genes & development 25 (5), 445-459, 2011
The spliceosome: the ultimate RNA chaperone and sculptor
P Papasaikas, J Valcárcel
Trends in biochemical sciences 41 (1), 33-45, 2016
Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks
E Sebestyén, B Singh, B Miñana, A Pagès, F Mateo, MA Pujana, ...
Genome research 26 (6), 732-744, 2016
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