| Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart, X Wang, X Zhang, ... Nature medicine 23 (1), 60-68, 2017 | 304 | 2017 |
| T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex JJ Adams, S Narayanan, B Liu, ME Birnbaum, AC Kruse, NA Bowerman, ... Immunity 35 (5), 681-693, 2011 | 286 | 2011 |
| The molecular basis of TCR germline bias for MHC is surprisingly simple K Christopher Garcia, JJ Adams, D Feng, LK Ely Nature immunology 10 (2), 143-147, 2009 | 283 | 2009 |
| CDR-H3 diversity is not required for antigen recognition by synthetic antibodies H Persson, W Ye, A Wernimont, JJ Adams, A Koide, S Koide, R Lam, ... Journal of molecular biology 425 (4), 803-811, 2013 | 185 | 2013 |
| Mechanism of bacterial cell-surface attachment revealed by the structure of cellulosomal type II cohesin-dockerin complex JJ Adams, G Pal, Z Jia, SP Smith Proceedings of the National Academy of Sciences 103 (2), 305-310, 2006 | 139 | 2006 |
| Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity JJ Adams, S Narayanan, ME Birnbaum, SS Sidhu, SJ Blevins, MH Gee, ... Nature immunology 17 (1), 87-94, 2016 | 130 | 2016 |
| A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo M Uppalapati, DJ Lee, K Mandal, H Li, LP Miranda, J Lowitz, J Kenney, ... ACS chemical biology 11 (4), 1058-1065, 2016 | 95 | 2016 |
| A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models B Ling, K Watt, S Banerjee, D Newsted, P Truesdell, J Adams, SS Sidhu, ... Oncotarget 8 (35), 58372, 2017 | 78 | 2017 |
| Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice Y Tao, M Mis, L Blazer, M Ustav, Z Steinhart, R Chidiac, E Kubarakos, ... Elife 8, e46134, 2019 | 75 | 2019 |
| Synthetic antibody technologies JJ Adams, SS Sidhu Current Opinion in Structural Biology 24, 1-9, 2014 | 74 | 2014 |
| Portrait of an enzyme, a complete structural analysis of a multimodular β-N-acetylglucosaminidase from Clostridium perfringens E Ficko-Blean, KJ Gregg, JJ Adams, JH Hehemann, M Czjzek, SP Smith, ... Journal of biological chemistry 284 (15), 9876-9884, 2009 | 54 | 2009 |
| Structural basis of Clostridium perfringens toxin complex formation JJ Adams, K Gregg, EA Bayer, AB Boraston, SP Smith Proceedings of the National Academy of Sciences 105 (34), 12194-12199, 2008 | 51 | 2008 |
| Structural Characterization of Type II Dockerin Module from the Cellulosome of Clostridium thermocellum: Calcium-Induced Effects on Conformation and Target … JJ Adams, BA Webb, HL Spencer, SP Smith Biochemistry 44 (6), 2173-2182, 2005 | 51 | 2005 |
| Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies SB Pollock, A Hu, Y Mou, AJ Martinko, O Julien, M Hornsby, L Ploder, ... Proceedings of the National Academy of Sciences 115 (11), 2836-2841, 2018 | 48 | 2018 |
| Blockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models D Newsted, S Banerjee, K Watt, S Nersesian, P Truesdell, LL Blazer, ... Oncoimmunology 8 (2), e1539613, 2019 | 47 | 2019 |
| Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1 KE Duncan, BR Dempsey, LE Killip, J Adams, ML Bailey, GA Lajoie, ... American Chemical Society, 2011 | 47 | 2011 |
| A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties Z Pavlovic, JJ Adams, LL Blazer, AK Gakhal, N Jarvik, Z Steinhart, ... MAbs 10 (8), 1157-1167, 2018 | 46 | 2018 |
| Cotargeting ephrin receptor tyrosine kinases A2 and A3 in cancer stem cells reduces growth of recurrent glioblastoma MA Qazi, P Vora, C Venugopal, J Adams, M Singh, A Hu, M Gorelik, ... Cancer Research 78 (17), 5023-5037, 2018 | 46 | 2018 |
| Insights into higher-order organization of the cellulosome revealed by a dissect-and-build approach: crystal structure of interacting Clostridium thermocellum multimodular … JJ Adams, MA Currie, S Ali, EA Bayer, Z Jia, SP Smith Journal of molecular biology 396 (4), 833-839, 2010 | 45 | 2010 |
| Laser-engineered heavy hydrocarbons: Old materials with new opportunities X Zang, C Jian, S Ingersoll, H Li, JJ Adams, Z Lu, N Ferralis, JC Grossman Science Advances 6 (17), eaaz5231, 2020 | 41 | 2020 |
