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Valerie Sim
Valerie Sim
Verified email at ualberta.ca - Homepage
Title
Cited by
Cited by
Year
The most infectious prion protein particles
JR Silveira, GJ Raymond, AG Hughson, RE Race, VL Sim, SF Hayes, ...
Nature 437 (7056), 257-261, 2005
10962005
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein
R Atarashi, RA Moore, VL Sim, AG Hughson, DW Dorward, HA Onwubiko, ...
Nature methods 4 (8), 645-650, 2007
4002007
The therapeutic potential of chemical chaperones in protein folding diseases
L Cortez, V Sim
Prion 8 (2), 197-202, 2014
2582014
Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils
VL Sim, B Caughey
Neurobiology of aging 30 (12), 2031-2042, 2009
1152009
Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor
JGR Weaver, A Tarze, TC Moffat, M LeBras, A Deniaud, C Brenner, ...
The Journal of clinical investigation 115 (7), 1828-1838, 2005
1022005
The mechanism of membrane disruption by cytotoxic amyloid oligomers formed by prion protein (106–126) is dependent on bilayer composition
P Walsh, G Vanderlee, J Yau, J Campeau, VL Sim, CM Yip, S Sharpe
Journal of Biological Chemistry 289 (15), 10419-10430, 2014
792014
Recent advances in prion chemotherapeutics
VL Sim, B Caughey
Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2009
752009
Bile acids reduce prion conversion, reduce neuronal loss, and prolong male survival in models of prion disease
LM Cortez, J Campeau, G Norman, M Kalayil, J Van der Merwe, ...
Journal of virology 89 (15), 7660-7672, 2015
712015
Prion strain-dependent differences in conversion of mutant prion proteins in cell culture
R Atarashi, VL Sim, N Nishida, B Caughey, S Katamine
Journal of virology 80 (16), 7854-7862, 2006
592006
Structure-based peptide design to modulate amyloid beta aggregation and reduce cytotoxicity
J Kumar, R Namsechi, VL Sim
PLoS One 10 (6), e0129087, 2015
582015
Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein
AN Gupta, K Neupane, N Rezajooei, LM Cortez, VL Sim, MT Woodside
Nature Communications 7 (1), 12058, 2016
482016
D-amino acid-based peptide inhibitors as early or preventative therapy in Alzheimer disease
J Kumar, V Sim
Prion 8 (1), 119-124, 2014
482014
Early increase and late decrease of purkinje cell dendritic spine density in prion-infected organotypic mouse cerebellar cultures
JL Campeau, G Wu, JR Bell, J Rasmussen, VL Sim
PloS one 8 (12), e81776, 2013
432013
Metronidazole susceptibility and the presence of hydrogenase in pathogenic bacteria
DL Church, RD Bryant, V Sim, EJ Laishley
Anaerobe 2 (3), 147-153, 1996
361996
Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication in α-synuclein aggregation
CM Torres-Bugeau, CL Ávila, R Raisman-Vozari, D Papy-Garcia, R Itri, ...
Journal of Biological Chemistry 287 (4), 2398-2409, 2012
342012
Molecular heterosis of prion protein β-oligomers: A potential mechanism of human resistance to disease
A Tahiri-Alaoui, VL Sim, B Caughey, W James
Journal of biological chemistry 281 (45), 34171-34178, 2006
312006
Infectious prions accumulate to high levels in non proliferative C2C12 myotubes
A Herbst, P Banser, CD Velasquez, CE Mays, VL Sim, D Westaway, ...
PLoS Pathogens 9 (11), e1003755, 2013
302013
Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice
T Ali, S Hannaoui, S Nemani, W Tahir, I Zemlyankina, P Cherry, SY Shim, ...
Acta Neuropathologica Communications 9, 1-14, 2021
262021
The Effects of N-terminal Mutations on β-amyloid Peptide Aggregation and Toxicity
BV Foroutanpay, J Kumar, SG Kang, N Danaei, D Westaway, VL Sim, ...
Neuroscience 379, 177-188, 2018
252018
Toll‐like receptor‐mediated immune response inhibits prion propagation
SG Kang, C Kim, LM Cortez, M Carmen Garza, J Yang, H Wille, VL Sim, ...
Glia 64 (6), 937-951, 2016
232016
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