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David Westaway
David Westaway
Verified email at ualberta.ca
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Year
A cellular gene encodes scrapie PrP 27-30 protein
B Oesch, D Westaway, M Wälchli, MP McKinley, SBH Kent, R Aebersold, ...
Cell 40 (4), 735-746, 1985
20471985
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
C Janus, J Pearson, JA McLaurin, PM Mathews, Y Jiang, SD Schmidt, ...
Nature 408 (6815), 979-982, 2000
20232000
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
M Citron, D Westaway, W Xia, G Carlson, T Diehl, G Levesque, ...
Nature medicine 3 (1), 67-72, 1997
18491997
The cellular prion protein binds copper in vivo
DR Brown, K Qin, JW Herms, A Madlung, J Manson, R Strome, PE Fraser, ...
Nature 390 (6661), 684-687, 1997
16751997
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
JH Lee, WH Yu, A Kumar, S Lee, PS Mohan, CM Peterhoff, DM Wolfe, ...
Cell 141 (7), 1146-1158, 2010
12432010
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
MA Chishti, DS Yang, C Janus, AL Phinney, P Horne, J Pearson, ...
Journal of Biological Chemistry 276 (24), 21562-21570, 2001
11932001
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
SB Prusiner, M Scott, D Foster, KM Pan, D Groth, C Mirenda, M Torchia, ...
Cell 63 (4), 673-686, 1990
11561990
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
K Basler, B Oesch, M Scott, D Westaway, M Wälchli, DF Groth, ...
Cell 46 (3), 417-428, 1986
11551986
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
K Hsiao, HF Baker, TJ Crow, M Poulter, F Owen, JD Terwilliger, ...
Nature 338 (6213), 342-345, 1989
11421989
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques
M Scott, D Foster, C Mirenda, D Serban, F Coufal, M Wälchli, M Torchia, ...
Cell 59 (5), 847-857, 1989
9121989
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyrindine (MPTP) and oxidative stress
RH Kim, PD Smith, H Aleyasin, S Hayley, MP Mount, S Pownall, ...
Proceedings of the National Academy of Sciences 102 (14), 5215-5220, 2005
8342005
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel
RC Moore, IY Lee, GL Silverman, PM Harrison, R Strome, C Heinrich, ...
Journal of molecular biology 292 (4), 797-817, 1999
6941999
Distinct prion proteins in short and long scrapie incubation period mice
D Westaway, PA Goodman, CA Mirenda, MP McKinley, GA Carlson, ...
Cell 51 (4), 651-662, 1987
6371987
Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis
J McLaurin, R Cecal, ME Kierstead, X Tian, AL Phinney, M Manea, ...
Nature medicine 8 (11), 1263-1269, 2002
5672002
Interactions between β-amyloid and central cholinergic neurons: implications for Alzheimer’s disease
S Kar, SPM Slowikowski, D Westaway, HTJ Mount
Journal of Psychiatry and Neuroscience 29 (6), 427-441, 2004
4912004
Linkage of prion protein and scrapie incubation time genes
GA Carlson, DT Kingsbury, PA Goodman, S Coleman, ST Marshall, ...
Cell 46 (4), 503-511, 1986
4911986
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
DS Yang, P Stavrides, PS Mohan, S Kaushik, A Kumar, M Ohno, ...
Brain 134 (1), 258-277, 2011
4852011
Molecular cloning of a human prion protein cDNA
HA KRETZSCHMAR, LE STOWRING, D WESTAWAY, WH STUBBLEBINE, ...
Dna 5 (4), 315-324, 1986
4621986
Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model
JA McLaurin, ME Kierstead, ME Brown, CA Hawkes, MHL Lambermon, ...
Nature medicine 12 (7), 801-808, 2006
4522006
Presenilin 1 controls γ-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons
WG Annaert, L Levesque, K Craessaerts, I Dierinck, G Snellings, ...
The Journal of cell biology 147 (2), 277-294, 1999
4331999
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