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David Alan Young
David Alan Young
Verified email at ncl.ac.uk - Homepage
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Year
Expression profiling of metalloproteinases and their inhibitors in cartilage
L Kevorkian, DA Young, C Darrah, ST Donell, L Shepstone, S Porter, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2004
5142004
The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-β1
MC Hall, DA Young, JG Waters, AD Rowan, A Chantry, DR Edwards, ...
Journal of Biological Chemistry 278 (12), 10304-10313, 2003
3362003
Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
JL Scott, C Gabrielides, RK Davidson, TE Swingler, IM Clark, GA Wallis, ...
Annals of the rheumatic diseases 69 (8), 1502-1510, 2010
2782010
The expression and function of microRNAs in chondrogenesis and osteoarthritis
TE Swingler, G Wheeler, V Carmont, HR Elliott, MJ Barter, M Abu‐Elmagd, ...
Arthritis & Rheumatism 64 (6), 1909-1919, 2012
2682012
Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases
W Hui, GJ Litherland, MS Elias, GI Kitson, TE Cawston, AD Rowan, ...
Annals of the rheumatic diseases 71 (3), 455-462, 2012
2542012
Proteinases involved in matrix turnover during cartilage and bone breakdown
TE Cawston, DA Young
Cell and tissue research 339, 221-235, 2010
2242010
Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs
MJ Barter, C Bui, DA Young
Osteoarthritis and cartilage 20 (5), 339-349, 2012
2102012
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption
DA Young, RL Lakey, CJ Pennington, D Jones, L Kevorkian, DR Edwards, ...
Arthritis research & therapy 7, 1-10, 2005
2082005
Characterization of the cartilage DNA methylome in knee and hip osteoarthritis
MD Rushton, LN Reynard, MJ Barter, R Refaie, KS Rankin, DA Young, ...
Arthritis & rheumatology 66 (9), 2450-2460, 2014
1892014
Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage
W Hui, DA Young, AD Rowan, X Xu, TE Cawston, CJ Proctor
Annals of the rheumatic diseases 75 (2), 449-458, 2016
1612016
Mitochondrial dysfunction in osteoarthritis is associated with down‐regulation of superoxide dismutase 2
C Gavriilidis, S Miwa, T von Zglinicki, RW Taylor, DA Young
Arthritis & Rheumatism 65 (2), 378-387, 2013
1472013
The function of microRNAs in cartilage and osteoarthritis
T Swingler, L Niu, P Smith, P Paddy, L Le, M Barter, D Young, I Clark
Clinical and experimental rheumatology 37 (5), 40-47, 2019
1442019
The microRNA-29 family in cartilage homeostasis and osteoarthritis
LTT Le, TE Swingler, N Crowe, TL Vincent, MJ Barter, ST Donell, ...
Journal of molecular medicine 94, 583-596, 2016
1402016
Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation
LN Reynard, C Bui, EG Canty-Laird, DA Young, J Loughlin
Human molecular genetics 20 (17), 3450-3460, 2011
1362011
cAMP response element‐binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular …
C Bui, MJ Barter, JL Scott, Y Xu, M Galler, LN Reynard, AD Rowan, ...
The FASEB Journal 26 (7), 3000-3011, 2012
1252012
Differential Toll-like receptor-dependent collagenase expression in chondrocytes
Q Zhang, W Hui, GJ Litherland, MJ Barter, R Davidson, C Darrah, ...
Annals of the rheumatic diseases 67 (11), 1633-1641, 2008
1132008
Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis
JM Milner, A Patel, RK Davidson, TE Swingler, A Desilets, DA Young, ...
Arthritis & Rheumatism 62 (7), 1955-1966, 2010
1042010
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis
JM Milner, L Kevorkian, DA Young, D Jones, R Wait, ST Donell, E Barksby, ...
Arthritis research & therapy 8, 1-8, 2006
1032006
Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis
JM Milner, AD Rowan, TE Cawston, DA Young
Arthritis research & therapy 8, 1-12, 2006
1012006
Interplay between genetics and epigenetics in osteoarthritis
SJ Rice, F Beier, DA Young, J Loughlin
Nature Reviews Rheumatology 16 (5), 268-281, 2020
1002020
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