Cytoplasmic steps of peptidoglycan biosynthesis H Barreteau, A Kovač, A Boniface, M Sova, S Gobec, D Blanot FEMS microbiology reviews 32 (2), 168-207, 2008 | 925 | 2008 |
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor B Brus, U Kosak, S Turk, A Pislar, N Coquelle, J Kos, J Stojan, JP Colletier, ... Journal of medicinal chemistry 57 (19), 8167-8179, 2014 | 276 | 2014 |
Inhibitors of cathepsin B R Frlan, S Gobec Current medicinal chemistry 13 (19), 2309-2327, 2006 | 174 | 2006 |
The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity U Kosak, B Brus, D Knez, S Zakelj, J Trontelj, A Pislar, R Sink, M Jukic, ... Journal of medicinal chemistry 61 (1), 119-139, 2018 | 150 | 2018 |
Development of an in-vivo active reversible butyrylcholinesterase inhibitor U Košak, B Brus, D Knez, R Šink, S Žakelj, J Trontelj, A Pišlar, J Šlenc, ... Scientific reports 6 (1), 39495, 2016 | 147 | 2016 |
False positives in the early stages of drug discovery R Sink, S Gobec, S Pecar, A Zega Current medicinal chemistry 17 (34), 4231-4255, 2010 | 147 | 2010 |
Endocrine Disruptome An Open Source Prediction Tool for Assessing Endocrine Disruption Potential through Nuclear Receptor Binding K Kolšek, J Mavri, M Sollner Dolenc, S Gobec, S Turk Journal of chemical information and modeling 54 (4), 1254-1267, 2014 | 135 | 2014 |
Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2, 4-dione inhibitors of MurD ligase N Zidar, T Tomašić, R Šink, V Rupnik, A Kovac, S Turk, D Patin, ... Journal of medicinal chemistry 53 (18), 6584-6594, 2010 | 126 | 2010 |
A road map for prioritizing warheads for cysteine targeting covalent inhibitors P Abranyi-Balogh, L Petri, T Imre, P Szijj, A Scarpino, M Hrast, A Mitrović, ... European journal of medicinal chemistry 160, 94-107, 2018 | 123 | 2018 |
Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F M Hrast, I Sosič, R Šink, S Gobec Bioorganic chemistry 55, 2-15, 2014 | 115 | 2014 |
Inhibitors of 17β-hydroxysteroid dehydrogenase type 1 S Gobec, P Brozic, TL Rizner Current medicinal chemistry 15 (2), 137-150, 2008 | 111 | 2008 |
Structural characterization and biological evaluation of a clioquinol–ruthenium complex with copper-independent antileukaemic activity M Gobec, J Kljun, I Sosič, I Mlinarič-Raščan, M Uršič, S Gobec, I Turel Dalton Transactions 43 (24), 9045-9051, 2014 | 107 | 2014 |
Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds B Mirković, M Renko, S Turk, I Sosič, Z Jevnikar, N Obermajer, D Turk, ... ChemMedChem 6 (8), 1351, 2011 | 104 | 2011 |
Antifungal activity of cinnamic acid derivatives involves inhibition of benzoate 4‐hydroxylase (CYP53) B Korošec, M Sova, S Turk, N Kraševec, M Novak, L Lah, J Stojan, ... Journal of applied microbiology 116 (4), 955-966, 2014 | 100 | 2014 |
Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase M Kotnik, J Humljan, C Contreras-Martel, M Oblak, K Kristan, M Hervé, ... Journal of molecular biology 370 (1), 107-115, 2007 | 100 | 2007 |
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta … D Panek, A Więckowska, T Wichur, M Bajda, J Godyń, J Jończyk, K Mika, ... European journal of medicinal chemistry 125, 676-695, 2017 | 94 | 2017 |
5‐Benzylidenethiazolidin‐4‐ones as multitarget inhibitors of bacterial Mur ligases T Tomašić, N Zidar, A Kovač, S Turk, M Simčič, D Blanot, ... ChemMedChem: Chemistry Enabling Drug Discovery 5 (2), 286-295, 2010 | 93 | 2010 |
Novel Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme, J Humljan, M Kotnik, C Contreras-Martel, D Blanot, U Urleb, A Dessen, ... Journal of medicinal chemistry 51 (23), 7486-7494, 2008 | 91 | 2008 |
LiSiCA: a software for ligand-based virtual screening and its application for the discovery of butyrylcholinesterase inhibitors S Lešnik, T Štular, B Brus, D Knez, S Gobec, D Janezic, J Konc Journal of chemical information and modeling 55 (8), 1521-1528, 2015 | 90 | 2015 |
Novel multi-target-directed ligands for Alzheimer's disease: combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation A Więckowska, M Kołaczkowski, A Bucki, J Godyń, M Marcinkowska, ... European Journal of Medicinal Chemistry 124, 63-81, 2016 | 87 | 2016 |