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Changsheng Zhang
Changsheng Zhang
Professor of Marine Chemical Microbiology, South China Sea Institute of Oceanology
Adresă de e-mail confirmată pe scsio.ac.cn - Pagina de pornire
Titlu
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Minimum information about a biosynthetic gene cluster
MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ...
Nature chemical biology 11 (9), 625-631, 2015
8512015
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
S Kang, M Yang, Z Hong, L Zhang, Z Huang, X Chen, S He, Z Zhou, ...
Acta Pharmaceutica Sinica B 10 (7), 1228-1238, 2020
6502020
Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions
C Zhang, BR Griffith, Q Fu, C Albermann, X Fu, IK Lee, L Li, JS Thorson
Science 313 (5791), 1291-1294, 2006
3252006
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution
GJ Williams, C Zhang, JS Thorson
Nature chemical biology 3 (10), 657-662, 2007
3112007
Antibiotic optimization via in vitro glycorandomization
X Fu, C Albermann, J Jiang, J Liao, C Zhang, JS Thorson
Nature biotechnology 21 (12), 1467-1469, 2003
2722003
Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate
H Huang, Y Yao, Z He, T Yang, J Ma, X Tian, Y Li, C Huang, X Chen, W Li, ...
Journal of natural products 74 (10), 2122-2127, 2011
1862011
Spiroindimicins A–D: New bisindole alkaloids from a deep-sea-derived actinomycete
W Zhang, Z Liu, S Li, T Yang, Q Zhang, L Ma, X Tian, H Zhang, C Huang, ...
Organic letters 14 (13), 3364-3367, 2012
1622012
Diversifying vancomycin via chemoenzymatic strategies
X Fu, C Albermann, C Zhang, JS Thorson
Organic Letters 7 (8), 1513-1515, 2005
1352005
N–N-Coupled Indolosesquiterpene atropo-diastereomers from a marine-derived Actinomycete
Q Zhang, A Mándi, S Li, Y Chen, W Zhang, X Tian, H Zhang, H Li, ...
European Journal of Organic Chemistry 2012 (27), 5256-5262, 2012
1202012
Optimizing glycosyltransferase specificity via “hot spot” saturation mutagenesis presents a catalyst for novobiocin glycorandomization
GJ Williams, RD Goff, C Zhang, JS Thorson
Chemistry & biology 15 (4), 393-401, 2008
1172008
Mechanistic insights into polycycle formation by reductive cyclization in ikarugamycin biosynthesis
G Zhang, W Zhang, Q Zhang, T Shi, L Ma, Y Zhu, S Li, H Zhang, YL Zhao, ...
Angewandte Chemie International Edition 53 (19), 4840-4844, 2014
1072014
Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams
S Saha, W Zhang, G Zhang, Y Zhu, Y Chen, W Liu, C Yuan, Q Zhang, ...
Chemical Science 8 (2), 1607-1612, 2017
1062017
Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase
Y Xiao, S Li, S Niu, L Ma, G Zhang, H Zhang, G Zhang, J Ju, C Zhang
Journal of the American Chemical Society 133 (4), 1092-1105, 2011
1062011
Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299
S Li, X Tian, S Niu, W Zhang, Y Chen, H Zhang, X Yang, W Zhang, W Li, ...
Marine drugs 9 (8), 1428-1439, 2011
1052011
Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127
S Niu, S Li, Y Chen, X Tian, H Zhang, G Zhang, W Zhang, X Yang, ...
The Journal of antibiotics 64 (11), 711-716, 2011
1032011
Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3)
W Lin, K Das, D Degen, A Mazumder, D Duchi, D Wang, YW Ebright, ...
Molecular cell 70 (1), 60-71. e15, 2018
972018
The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility
C Zhang, C Albermann, X Fu, JS Thorson
Journal of the American Chemical Society 128 (51), 16420-16421, 2006
972006
Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses
SA Borisova, C Zhang, H Takahashi, H Zhang, AW Wong, JS Thorson, ...
Angewandte Chemie International Edition 45 (17), 2748-2753, 2006
972006
Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis
H Li, Q Zhang, S Li, Y Zhu, G Zhang, H Zhang, X Tian, S Zhang, J Ju, ...
Journal of the American Chemical Society 134 (21), 8996-9005, 2012
952012
Biosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps
J Ma, Z Wang, H Huang, M Luo, D Zuo, B Wang, A Sun, YQ Cheng, ...
Angewandte Chemie 123 (34), 7943-7948, 2011
922011
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