Andrew RJ Lawson
Andrew RJ Lawson
Wellcome Sanger Institute
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Somatic mutant clones colonize the human esophagus with age
I Martincorena, JC Fowler, A Wabik, ARJ Lawson, F Abascal, MWJ Hall, ...
Science 362 (6417), 911-917, 2018
Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas
T Forshew, RG Tatevossian, ARJ Lawson, J Ma, G Neale, ...
The Journal of Pathology: A Journal of the Pathological Society of Great …, 2009
Osimertinib benefit inEGFR-mutant NSCLC patients withT790M-mutation detected by circulating tumour DNA
J Remon, C Caramella, C Jovelet, L Lacroix, A Lawson, S Smalley, ...
Annals of Oncology 28 (4), 784-790, 2017
Somatic mutation landscapes at single-molecule resolution
F Abascal, LMR Harvey, E Mitchell, ARJ Lawson, SV Lensing, P Ellis, ...
Nature 593 (7859), 405-410, 2021
Extensive heterogeneity in somatic mutation and selection in the human bladder
ARJ Lawson, F Abascal, THH Coorens, Y Hooks, L O’Neill, C Latimer, ...
Science 370 (6512), 75-82, 2020
Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA
D Gale, ARJ Lawson, K Howarth, M Madi, B Durham, S Smalley, ...
PloS one 13 (3), e0194630, 2018
MAPK pathway activation and the origins of pediatric low‐grade astrocytomas
RG Tatevossian, ARJ Lawson, T Forshew, GFL Hindley, DW Ellison, ...
Journal of cellular physiology 222 (3), 509-514, 2010
Somatic mutation rates scale with lifespan across mammals
A Cagan, A Baez-Ortega, N Brzozowska, F Abascal, THH Coorens, ...
Nature 604 (7906), 517-524, 2022
Patterns of within-host genetic diversity in SARS-CoV-2
G Tonkin-Hill, I Martincorena, R Amato, ARJ Lawson, M Gerstung, ...
Elife 10, e66857, 2021
MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas
RG Tatevossian, B Tang, J Dalton, T Forshew, AR Lawson, J Ma, G Neale, ...
Acta neuropathologica 120, 731-743, 2010
RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology
ARJ Lawson, GFL Hindley, T Forshew, RG Tatevossian, GA Jamie, ...
Genome research 21 (4), 505-514, 2011
RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort
ARJ Lawson, RG Tatevossian, KP Phipps, SR Picker, A Michalski, ...
Acta Neuropathologica 120, 271-273, 2010
Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing
P Ellis, L Moore, MA Sanders, TM Butler, SF Brunner, H Lee-Six, ...
Nature Protocols 16 (2), 841-871, 2021
Extensive phylogenies of human development inferred from somatic mutations
THH Coorens, L Moore, PS Robinson, R Sanghvi, J Christopher, ...
Nature 597 (7876), 387-392, 2021
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
PS Robinson, THH Coorens, C Palles, E Mitchell, F Abascal, S Olafsson, ...
Nature Genetics 53 (10), 1434-1442, 2021
Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways
TA Jones, JN Jeyapalan, T Forshew, RG Tatevossian, ARJ Lawson, ...
Acta neuropathologica communications 3 (1), 1-13, 2015
Analytical performance and validation of an enhanced TAm-Seq circulating tumor DNA sequencing assay
D Gale, V Plagnol, A Lawson, M Pugh, S Smalley, K Howarth, M Madi, ...
Cancer Research 76 (14_Supplement), 3639-3639, 2016
High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells
M Boettcher, A Lawson, V Ladenburger, J Fredebohm, J Wolf, ...
BMC genomics 15, 1-11, 2014
Elevated somatic mutation burdens in normal human cells due to defective DNA polymerases
PS Robinson, THH Coorens, C Palles, E Mitchell, F Abascal, S Olafsson, ...
bioRxiv, 2020.06. 23.167668, 2020
Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight
CD Hurst, G Cheng, FM Platt, MAA Castro, SM Nour-Al-Dain, P Eriksson, ...
Cell Reports Medicine 2 (12), 100472, 2021
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