| The OARSI histopathology initiative–recommendations for histological assessments of osteoarthritis in the mouse SS Glasson, MG Chambers, WB Van Den Berg, CB Little Osteoarthritis and cartilage 18, S17-S23, 2010 | 1428 | 2010 |
| ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro H Stanton, FM Rogerson, CJ East, SB Golub, KE Lawlor, CT Meeker, ... Nature 434 (7033), 648-652, 2005 | 1028 | 2005 |
| Are animal models useful for studying human disc disorders/degeneration? M Alini, SM Eisenstein, K Ito, C Little, AA Kettler, K Masuda, J Melrose, ... European Spine Journal 17, 2-19, 2008 | 833 | 2008 |
| Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development CB Little, A Barai, D Burkhardt, SM Smith, AJ Fosang, Z Werb, M Shah, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2009 | 689 | 2009 |
| Mechanisms involved in cartilage proteoglycan catabolism B Caterson, CR Flannery, CE Hughes, CB Little Matrix Biology 19 (4), 333-344, 2000 | 394 | 2000 |
| n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation CL Curtis, CE Hughes, CR Flannery, CB Little, JL Harwood, B Caterson Journal of Biological Chemistry 275 (2), 721-724, 2000 | 386 | 2000 |
| Post-traumatic osteoarthritis: from mouse models to clinical trials CB Little, DJ Hunter Nature Reviews Rheumatology 9 (8), 485-497, 2013 | 281 | 2013 |
| Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n‐3 fatty acids CL Curtis, SG Rees, CB Little, CR Flannery, CE Hughes, C Wilson, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2002 | 260 | 2002 |
| Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro CB Little, CR Flannery, CE Hughes, JS MORT, PJ ROUGHLEY, C DENT, ... Biochemical Journal 344 (1), 61-68, 1999 | 247 | 1999 |
| Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair CB Little, CT Meeker, SB Golub, KE Lawlor, PJ Farmer, SM Smith, ... The Journal of clinical investigation 117 (6), 1627-1636, 2007 | 245 | 2007 |
| Proteoglycan degradation by the ADAMTS family of proteinases H Stanton, J Melrose, CB Little, AJ Fosang Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1812 (12 …, 2011 | 244 | 2011 |
| Histopathology atlas of animal model systems–overview of guiding principles T Aigner, JL Cook, N Gerwin, SS Glasson, S Laverty, CB Little, ... Osteoarthritis and cartilage 18, S2-S6, 2010 | 227 | 2010 |
| The OARSI histopathology initiative–recommendations for histological assessments of osteoarthritis in sheep and goats CB Little, MM Smith, MA Cake, RA Read, MJ Murphy, FP Barry Osteoarthritis and cartilage 18, S80-S92, 2010 | 225 | 2010 |
| Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis BY Chan, ES Fuller, AK Russell, SM Smith, MM Smith, MT Jackson, ... Osteoarthritis and Cartilage 19 (7), 874-885, 2011 | 221 | 2011 |
| Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis AA Young, S McLennan, MM Smith, SM Smith, MA Cake, RA Read, ... Arthritis research & therapy 8, 1-6, 2006 | 198 | 2006 |
| What constitutes an “animal model of osteoarthritis”–the need for consensus? CB Little, S Zaki Osteoarthritis and cartilage 20 (4), 261-267, 2012 | 186 | 2012 |
| Catabolism of aggrecan, decorin and biglycan in tendon SG Rees, CR Flannery, CB Little, CE HUGHES, B Caterson, CM Dent Biochemical Journal 350 (1), 181-188, 2000 | 179 | 2000 |
| Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation CB Little, CE Hughes, CL Curtis, MJ Janusz, R Bohne, S Wang-Weigand, ... Matrix Biology 21 (3), 271-288, 2002 | 174 | 2002 |
| Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin … CR Flannery, CB Little, B Caterson, CE Hughes Matrix Biology 18 (3), 225-237, 1999 | 168 | 1999 |
| Animal models of osteoarthritis CB Little, MM Smith Current Rheumatology Reviews 4 (3), 175-182, 2008 | 165 | 2008 |
