Paul B. Yu
Paul B. Yu
Harvard Medical School, Brigham and Women’s Hospital
Verified email at
Cited by
Cited by
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
PB Yu, CC Hong, C Sachidanandan, JL Babitt, DY Deng, SA Hoyng, ...
Nature chemical biology 4 (1), 33-41, 2008
BMP type I receptor inhibition reduces heterotopic ossification
PB Yu, DY Deng, CS Lai, CC Hong, GD Cuny, ML Bouxsein, DW Hong, ...
Nature medicine 14 (12), 1363-1369, 2008
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
L Long, ML Ormiston, X Yang, M Southwood, S Gräf, RD Machado, ...
Nature medicine 21 (7), 777-785, 2015
Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
GD Cuny, BY Paul, JK Laha, X Xing, JF Liu, CS Lai, DY Deng, ...
Bioorganic & medicinal chemistry letters 18 (15), 4388-4392, 2008
ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A
SJ Hatsell, V Idone, DMA Wolken, L Huang, HJ Kim, L Wang, X Wen, ...
Science translational medicine 7 (303), 303ra137-303ra137, 2015
Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells
J Hao, MA Daleo, CK Murphy, PB Yu, JN Ho, J Hu, RT Peterson, ...
PloS one 3 (8), e2904, 2008
Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis
M Derwall, R Malhotra, CS Lai, Y Beppu, E Aikawa, JS Seehra, WM Zapol, ...
Arteriosclerosis, thrombosis, and vascular biology 32 (3), 613-622, 2012
Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells
BY Paul, H Beppu, N Kawai, E Li, KD Bloch
Journal of Biological Chemistry 280 (26), 24443-24450, 2005
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
H Beppu, F Ichinose, N Kawai, RC Jones, PB Yu, WM Zapol, K Miyazono, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 287 (6 …, 2004
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts
N Kamiya, T Kobayashi, Y Mochida, PB Yu, M Yamauchi, HM Kronenberg, ...
Journal of Bone and Mineral Research 25 (2), 200-210, 2010
A new class of small molecule inhibitor of BMP signaling
CE Sanvitale, G Kerr, A Chaikuad, MC Ramel, AH Mohedas, S Reichert, ...
PloS one 8 (4), e62721, 2013
Targeting BMP signalling in cardiovascular disease and anaemia
NW Morrell, DB Bloch, P Ten Dijke, MJTH Goumans, A Hata, J Smith, ...
Nature Reviews Cardiology 13 (2), 106-120, 2016
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
AU Steinbicker, C Sachidanandan, AJ Vonner, RZ Yusuf, DY Deng, ...
Blood, The Journal of the American Society of Hematology 117 (18), 4915-4923, 2011
Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice
AU Steinbicker, TB Bartnikas, LK Lohmeyer, P Leyton, C Mayeur, SM Kao, ...
Blood, The Journal of the American Society of Hematology 118 (15), 4224-4230, 2011
Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva
T Fukuda, M Kohda, K Kanomata, J Nojima, A Nakamura, J Kamizono, ...
Journal of Biological Chemistry 284 (11), 7149-7156, 2009
Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells
JH Boergermann, J Kopf, PB Yu, P Knaus
The international journal of biochemistry & cell biology 42 (11), 1802-1807, 2010
Transforming growth factor β can stimulate Smad1 phosphorylation independently of bone morphogenic protein receptors
KH Wrighton, X Lin, BY Paul, XH Feng
Journal of Biological Chemistry 284 (15), 9755-9763, 2009
Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification
D Dey, J Bagarova, SJ Hatsell, KA Armstrong, L Huang, J Ermann, ...
Science translational medicine 8 (366), 366ra163-366ra163, 2016
Development of an ALK2-biased BMP type I receptor kinase inhibitor
AH Mohedas, X Xing, KA Armstrong, AN Bullock, GD Cuny, PB Yu
ACS chemical biology 8 (6), 1291-1302, 2013
Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
Y Xia, BY Paul, Y Sidis, H Beppu, KD Bloch, AL Schneyer, HY Lin
Journal of biological chemistry 282 (25), 18129-18140, 2007
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