Matthew L. Hillwig
Matthew L. Hillwig
Seton Hill University
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Minimum information about a biosynthetic gene cluster
MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ...
Nature chemical biology 11 (9), 625-631, 2015
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts
J Guo, YJ Zhou, ML Hillwig, Y Shen, L Yang, Y Wang, X Zhang, W Liu, ...
Proceedings of the National Academy of Sciences 110 (29), 12108-12113, 2013
A functional genomics approach to tanshinone biosynthesis provides stereochemical insights
W Gao, ML Hillwig, L Huang, G Cui, X Wang, J Kong, B Yang, RJ Peters
Organic letters 11 (22), 5170-5173, 2009
Functional identification of rice syn‐copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products
M Xu, ML Hillwig, S Prisic, RM Coates, RJ Peters
The Plant Journal 39 (3), 309-318, 2004
Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza
W Gao, HX Sun, H Xiao, G Cui, ML Hillwig, A Jackson, X Wang, Y Shen, ...
BMC genomics 15, 1-14, 2014
Inhibition of Prostaglandin E2 Production by Anti-inflammatory Hypericum perforatum Extracts and Constituents in RAW264.7 Mouse Macrophage Cells
KDP Hammer, ML Hillwig, AKS Solco, PM Dixon, K Delate, PA Murphy, ...
Journal of agricultural and food chemistry 55 (18), 7323-7331, 2007
A new family of iron-dependent halogenases acts on freestanding substrates
ML Hillwig, X Liu
Nature Chemical Biology 10 (11), 921-923, 2014
Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster
Q Wang, ML Hillwig, K Okada, K Yamazaki, Y Wu, S Swaminathan, ...
Journal of Biological Chemistry 287 (9), 6159-6168, 2012
Structural basis for halogenation by iron-and 2-oxo-glutarate-dependent enzyme WelO5
AJ Mitchell, Q Zhu, AO Maggiolo, NR Ananth, ML Hillwig, X Liu, AK Boal
Nature chemical biology 12 (8), 636-640, 2016
CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice
Q Wang, ML Hillwig, RJ Peters
The Plant Journal 65 (1), 87-95, 2011
CYP701A8: A Rice ent-Kaurene Oxidase Paralog Diverted to More Specialized Diterpenoid Metabolism
Q Wang, ML Hillwig, Y Wu, RJ Peters
Plant physiology 158 (3), 1418-1425, 2012
Biosynthesis of Ambiguine Indole Alkaloids in Cyanobacterium Fischerella ambigua
ML Hillwig, Q Zhu, X Liu
ACS chemical biology 9 (2), 372-377, 2014
Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents
DF Birt, MP Widrlechner, KDP Hammer, ML Hillwig, J Wei, GA Kraus, ...
Pharmaceutical biology 47 (8), 774-782, 2009
Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in the Stigonematalean Cyanobacterium Hapalosiphon welwitschii
ML Hillwig, HA Fuhrman, K Ittiamornkul, TJ Sevco, DH Kwak, X Liu
ChemBioChem 15 (5), 665-669, 2014
Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7
Y Wu, ML Hillwig, Q Wang, RJ Peters
FEBS letters 585 (21), 3446-3451, 2011
Domain loss has independently occurred multiple times in plant terpene synthase evolution
ML Hillwig, M Xu, T Toyomasu, MS Tiernan, G Wei, G Cui, L Huang, ...
The Plant Journal 68 (6), 1051-1060, 2011
Discovery of a promiscuous non‐heme iron halogenase in ambiguine alkaloid biogenesis: implication for an evolvable enzyme family for late‐stage halogenation of aliphatic …
ML Hillwig, Q Zhu, K Ittiamornkul, X Liu
Angewandte Chemie International Edition 55 (19), 5780-5784, 2016
Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis
S Mafu, M Jia, J Zi, D Morrone, Y Wu, M Xu, ML Hillwig, RJ Peters
Proceedings of the National Academy of Sciences 113 (9), 2526-2531, 2016
Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals
D Morrone, ML Hillwig, ME Mead, L Lowry, DB Fulton, RJ Peters
Biochemical Journal 435 (3), 589-595, 2011
A Novel Labda‐7,13E‐dien‐15‐ol‐Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii
S Mafu, ML Hillwig, RJ Peters
ChemBioChem 12 (13), 1984-1987, 2011
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