Cariprazine (RGH-188), a dopamine D3 receptor-preferring, D3/D2 dopamine receptor antagonist–partial agonist antipsychotic candidate: in vitro and neurochemical profile B Kiss, A Horváth, Z Némethy, É Schmidt, I Laszlovszky, G Bugovics, ... Journal of Pharmacology and Experimental Therapeutics 333 (1), 328-340, 2010 | 392 | 2010 |
Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood–brain barrier penetration models É Hellinger, S Veszelka, AE Tóth, F Walter, Á Kittel, ML Bakk, K Tihanyi, ... European journal of pharmaceutics and biopharmaceutics 82 (2), 340-351, 2012 | 228 | 2012 |
Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents I Gyertyán, B Kiss, K Sághy, J Laszy, G Szabó, T Szabados, LI Gémesi, ... Neurochemistry international 59 (6), 925-935, 2011 | 155 | 2011 |
Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors É Ágai-Csongor, G Domány, K Nógrádi, J Galambos, I Vágó, GM Keserű, ... Bioorganic & medicinal chemistry letters 22 (10), 3437-3440, 2012 | 100 | 2012 |
Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats M Sarvari, I Kallo, E Hrabovszky, N Solymosi, K Toth, I Liko, B Molnar, ... Endocrinology 151 (8), 3847-3862, 2010 | 68 | 2010 |
Neuroprotective Effects of Vinpocetine and its Major Metabolite Cis‐apovincaminic Acid on NMDA‐Induced Neurotoxicity in a Rat Entorhinal Cortex Lesion Model C Nyakas, K Felszeghy, R Szabo, JN Keijser, PGM Luiten, ... CNS neuroscience & therapeutics 15 (2), 89-99, 2009 | 68 | 2009 |
Insulin in flavin-containing monooxygenase regulation: flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes T Borbás, B Benkő, B Dalmadi, I Szabó, K Tihanyi European journal of pharmaceutical sciences 28 (1-2), 51-58, 2006 | 64 | 2006 |
[11C] vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate PET studies B Gulyás, C Halldin, Á Vas, RB Banati, E Shchukin, S Finnema, ... Journal of the neurological sciences 229, 219-223, 2005 | 62 | 2005 |
Isolation and properties of adenovirus type 2 proteinase. K Tihanyi, M Bourbonniere, A Houde, C Rancourt, JM Weber Journal of Biological Chemistry 268 (3), 1780-1785, 1993 | 58 | 1993 |
Drug penetration model of vinblastine-treated Caco-2 cultures É Hellinger, ML Bakk, P Pócza, K Tihanyi, M Vastag European journal of pharmaceutical sciences 41 (1), 96-106, 2010 | 57 | 2010 |
Translocator protein (TSPO 18 kDa) is expressed by neural stem and neuronal precursor cells B Varga, K Markó, N Hádinger, M Jelitai, K Demeter, K Tihanyi, Á Vas, ... Neuroscience letters 462 (3), 257-262, 2009 | 56 | 2009 |
Identification of active-site residues of the adenovirus endopeptidase. C Rancourt, K Tihanyi, M Bourbonniere, JM Weber Proceedings of the National Academy of Sciences 91 (3), 844-847, 1994 | 55 | 1994 |
Effects of Vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons K Tárnok, E Kiss, PGM Luiten, C Nyakas, K Tihanyi, K Schlett, ULM Eisel Neurochemistry international 53 (6-8), 289-295, 2008 | 51 | 2008 |
Physico-chemical profiling of antidepressive sertraline: Solubility, ionisation, lipophilicity K Deák, K Takács-Novák, K Tihanyi, B Noszál Medicinal chemistry 2 (4), 385-389, 2006 | 48 | 2006 |
Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes B Dalmadi, J Leibinger, S Szeberényi, T Borbás, S Farkas, ... Drug metabolism and disposition 31 (5), 631-636, 2003 | 47 | 2003 |
Estradiol and isotype-selective estrogen receptor agonists modulate the mesocortical dopaminergic system in gonadectomized female rats M Sárvári, L Deli, P Kocsis, L Márk, G Maász, E Hrabovszky, I Kalló, ... Brain research 1583, 1-11, 2014 | 46 | 2014 |
[41] Adenovirus endopeptidases JM Weber, K Tihanyi Methods in Enzymology 244, 595-604, 1994 | 43 | 1994 |
Piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same, and a process for the preparation of the active substance IR Simonek, D Bózsing, G Németh, G Simig, L Poszávácz, I Jakóczi, ... US Patent 6,469,168, 2002 | 41 | 2002 |
Solubility, delivery and ADME problems of drugs and drug candidates KK Tihanyi, M Vastag Bentham Science Publishers, 2011 | 37 | 2011 |
Effects of RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an orally active, selective dopamine D3 receptor partial agonist in animal … I Gyertyán, B Kiss, K Gál, I Laszlovszky, A Horvath, LI Gémesi, K Saghy, ... Journal of Pharmacology and Experimental Therapeutics 320 (3), 1268-1278, 2007 | 36 | 2007 |