| CD8α+ dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites M Mashayekhi, MM Sandau, IR Dunay, EM Frickel, A Khan, ... Immunity 35 (2), 249-259, 2011 | 462 | 2011 |
| TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain EM Frickel, R Riek, I Jelesarov, A Helenius, K Wüthrich, L Ellgaard Proceedings of the National Academy of Sciences 99 (4), 1954-1959, 2002 | 373 | 2002 |
| ERp57 is a multifunctional thiol-disulfide oxidoreductase EM Frickel, P Frei, M Bouvier, WF Stafford, A Helenius, R Glockshuber, ... Journal of Biological Chemistry 279 (18), 18277-18287, 2004 | 263 | 2004 |
| Calnexin, calreticulin, and ERp57: teammates in glycoprotein folding L Ellgaard, EM Frickel Cell biochemistry and biophysics 39, 223-247, 2003 | 249 | 2003 |
| Human GBP 1 is a microbe‐specific gatekeeper of macrophage apoptosis and pyroptosis D Fisch, H Bando, B Clough, V Hornung, M Yamamoto, AR Shenoy, ... The EMBO journal 38 (13), e100926, 2019 | 208 | 2019 |
| IRG and GBP host resistance factors target aberrant,“non-self” vacuoles characterized by the missing of “self” IRGM proteins AK Haldar, HA Saka, AS Piro, JD Dunn, SC Henry, GA Taylor, EM Frickel, ... PLoS pathogens 9 (6), e1003414, 2013 | 196 | 2013 |
| Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins AK Haldar, C Foltz, R Finethy, AS Piro, EM Feeley, DM Pilla-Moffett, ... Proceedings of the National Academy of Sciences 112 (41), E5628-E5637, 2015 | 173 | 2015 |
| Determinants of GBP Recruitment to Toxoplasma gondii Vacuoles and the Parasitic Factors That Control It S Virreira Winter, W Niedelman, KD Jensen, EE Rosowski, L Julien, ... PloS one 6 (9), e24434, 2011 | 159 | 2011 |
| The Toxoplasma parasitophorous vacuole: an evolving host–parasite frontier B Clough, EM Frickel Trends in parasitology 33 (6), 473-488, 2017 | 144 | 2017 |
| Parasite Stage-Specific Recognition of Endogenous Toxoplasma gondii-Derived CD8+ T Cell Epitopes EM Frickel, N Sahoo, J Hopp, MJ Gubbels, MPJ Craver, LJ Knoll, ... The Journal of infectious diseases 198 (11), 1625-1633, 2008 | 123 | 2008 |
| Differential Regulation of Effector- and Central-Memory Responses to Toxoplasma gondii Infection by IL-12 Revealed by Tracking of Tgd057-Specific CD8+ T Cells DC Wilson, GM Grotenbreg, K Liu, Y Zhao, EM Frickel, MJ Gubbels, ... PLoS pathogens 6 (3), e1000815, 2010 | 120 | 2010 |
| Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility AS Piro, D Hernandez, S Luoma, EM Feeley, R Finethy, A Yirga, ... MBio 8 (6), 10.1128/mbio. 01979-17, 2017 | 102 | 2017 |
| Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution EM Frickel, V Quesada, L Muething, MJ Gubbels, E Spooner, H Ploegh, ... Cellular microbiology 9 (6), 1601-1610, 2007 | 100 | 2007 |
| Domain Architecture of Protein-disulfide Isomerase Facilitates Its Dual Role as an Oxidase and an Isomerase in Ero1p-mediated Disulfide Formation*♦ MS Kulp, EM Frickel, L Ellgaard, JS Weissman Journal of Biological Chemistry 281 (2), 876-884, 2006 | 92 | 2006 |
| Toxoplasma gondii Superinfection and Virulence during Secondary Infection Correlate with the Exact ROP5/ROP18 Allelic Combination KDC Jensen, A Camejo, MB Melo, C Cordeiro, L Julien, GM Grotenbreg, ... MBio 6 (2), 10.1128/mbio. 02280-14, 2015 | 89 | 2015 |
| K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells B Clough, JD Wright, PM Pereira, EM Hirst, AC Johnston, R Henriques, ... PLoS pathogens 12 (11), e1006027, 2016 | 86 | 2016 |
| Defining host–pathogen interactions employing an artificial intelligence workflow D Fisch, A Yakimovich, B Clough, J Wright, M Bunyan, M Howell, J Mercer, ... Elife 8, e40560, 2019 | 83 | 2019 |
| Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii AC Johnston, A Piro, B Clough, M Siew, S Virreira Winter, J Coers, ... Cellular microbiology 18 (8), 1056-1064, 2016 | 82 | 2016 |
| Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death JP Saeij, EM Frickel Current opinion in microbiology 40, 72-80, 2017 | 80 | 2017 |
| Human GBP1 differentially targets Salmonella and Toxoplasma to license recognition of microbial ligands and caspase-mediated death D Fisch, B Clough, MC Domart, V Encheva, H Bando, AP Snijders, ... Cell reports 32 (6), 2020 | 77 | 2020 |
Hidde PloeghSenior Investigator, Program in Cellular and Molecular Medicine, Boston Children's HospitalVerified email at childrens.harvard.edu
