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Britta Will, Ph.D.
Britta Will, Ph.D.
Associate Professor, Albert Einstein College of Medicine
Adresă de e-mail confirmată pe einsteinmed.edu - Pagina de pornire
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Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal
EM Pietras, C Mirantes-Barbeito, S Fong, D Loeffler, LV Kovtonyuk, ...
Nature cell biology 18 (6), 607-618, 2016
6082016
Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations
B Will, L Zhou, TO Vogler, S Ben-Neriah, C Schinke, R Tamari, Y Yu, ...
Blood, The Journal of the American Society of Hematology 120 (10), 2076-2086, 2012
2542012
Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS
L Barreyro, B Will, B Bartholdy, L Zhou, TI Todorova, RF Stanley, ...
Blood, The Journal of the American Society of Hematology 120 (6), 1290-1298, 2012
2312012
Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level
J Chen, YR Kao, D Sun, TI Todorova, D Reynolds, SR Narayanagari, ...
Nature medicine 25 (1), 103-110, 2019
2222019
Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia
LA Carvajal, DB Neriah, A Senecal, L Benard, V Thiruthuvanathan, ...
Science translational medicine 10 (436), eaao3003, 2018
2122018
PU. 1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element
AK Ebralidze, FC Guibal, U Steidl, P Zhang, S Lee, B Bartholdy, MA Jorda, ...
Genes & development 22 (15), 2085-2092, 2008
2052008
New IDH1 mutant inhibitors for treatment of acute myeloid leukemia
UC Okoye-Okafor, B Bartholdy, J Cartier, EN Gao, B Pietrak, AR Rendina, ...
Nature chemical biology 11 (11), 878-886, 2015
1892015
IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells
C Schinke, O Giricz, W Li, A Shastri, S Gordon, L Barreyro, T Bhagat, ...
Blood, The Journal of the American Society of Hematology 125 (20), 3144-3152, 2015
1792015
Proteome-wide analysis of chaperone-mediated autophagy targeting motifs
P Kirchner, M Bourdenx, J Madrigal-Matute, S Tiano, A Diaz, BA Bartholdy, ...
PLoS biology 17 (5), e3000301, 2019
1692019
Chaperone-mediated autophagy sustains haematopoietic stem-cell function
S Dong, Q Wang, YR Kao, A Diaz, I Tasset, S Kaushik, ...
Nature 591 (7848), 117-123, 2021
1682021
Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation
M Roth, B Will, G Simkin, S Narayanagari, L Barreyro, B Bartholdy, ...
Blood, The Journal of the American Society of Hematology 120 (2), 386-394, 2012
1662012
A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia
U Steidl, C Steidl, A Ebralidze, B Chapuy, HJ Han, B Will, F Rosenbauer, ...
The Journal of clinical investigation 117 (9), 2611-2620, 2007
1462007
Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome
B Will, M Kawahara, JP Luciano, I Bruns, S Parekh, CL Erickson-Miller, ...
Blood, The Journal of the American Society of Hematology 114 (18), 3899-3908, 2009
1392009
Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment
B Will, TO Vogler, B Bartholdy, F Garrett-Bakelman, J Mayer, L Barreyro, ...
Nature immunology 14 (5), 437-445, 2013
133*2013
Minimal PU. 1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia
B Will, TO Vogler, S Narayanagari, B Bartholdy, TI Todorova, ...
Nature medicine 21 (10), 1172-1181, 2015
1252015
Stem and progenitor cell alterations in myelodysplastic syndromes
A Shastri, B Will, U Steidl, A Verma
Blood, The Journal of the American Society of Hematology 129 (12), 1586-1594, 2017
1202017
LSD1 inhibition exerts its antileukemic effect by recommissioning PU. 1-and C/EBPα-dependent enhancers in AML
M Cusan, SF Cai, HP Mohammad, A Krivtsov, A Chramiec, E Loizou, ...
Blood, The Journal of the American Society of Hematology 131 (15), 1730-1742, 2018
1092018
Pharmacological inhibition of the transcription factor PU. 1 in leukemia
I Antony-Debré, A Paul, J Leite, K Mitchell, HM Kim, LA Carvajal, ...
The Journal of clinical investigation 127 (12), 4297-4313, 2017
1072017
A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2
KB Kaufmann, A Gründer, T Hadlich, J Wehrle, M Gothwal, R Bogeska, ...
Journal of Experimental Medicine 209 (1), 35-50, 2012
842012
Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells
A Shastri, G Choudhary, M Teixeira, S Gordon-Mitchell, N Ramachandra, ...
The Journal of clinical investigation 128 (12), 5479-5488, 2018
772018
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