Eusebio Manchado
Eusebio Manchado
Research Scholar, Memorial Sloan Kettering Cancer Center (MSKCC)
Verified email at
Cited by
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In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
D Maddalo, E Manchado, CP Concepcion, C Bonetti, JA Vidigal, YC Han, ...
Nature 516 (7531), 423-427, 2014
Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling
S Weissmueller, E Manchado, M Saborowski, JP Morris IV, E Wagenblast, ...
Cell 157 (2), 382-394, 2014
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
I García-Higuera, E Manchado, P Dubus, M Cañamero, J Méndez, ...
Nature cell biology 10 (7), 802-811, 2008
A combinatorial strategy for treating KRAS-mutant lung cancer
E Manchado, S Weissmueller, JP Morris, CC Chen, R Wullenkord, ...
Nature 534 (7609), 647-651, 2016
Killing cells by targeting mitosis
E Manchado, M Guillamot, M Malumbres
Cell Death & Differentiation 19 (3), 369-377, 2012
Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α, δ phosphatase
E Manchado, M Guillamot, G de Cárcer, M Eguren, M Trickey, ...
Cancer cell 18 (6), 641-654, 2010
NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
M Ruscetti, J Leibold, MJ Bott, M Fennell, A Kulick, NR Salgado, CC Chen, ...
Science 362 (6421), 1416-1422, 2018
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer
KP O'Rourke, E Loizou, G Livshits, EM Schatoff, T Baslan, E Manchado, ...
Nature biotechnology 35 (6), 577-582, 2017
The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and-independent functions
E Manchado, M Eguren, M Malumbres
Biochemical Society Transactions 38 (1), 65-71, 2010
Kinase Regulation of Human MHC Class I Molecule Expression on Cancer CellsKinase Regulation of MHC-I in Tumors
EJ Brea, CY Oh, E Manchado, S Budhu, RS Gejman, G Mo, P Mondello, ...
Cancer immunology research 4 (11), 936-947, 2016
Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer
M Álvarez-Fernández, M Sanz-Flores, B Sanz-Castillo, M Salazar-Roa, ...
Cell Death & Differentiation, 1-13, 2017
Non-mitotic functions of the Anaphase-Promoting Complex
M Eguren, E Manchado, M Malumbres
Seminars in cell & developmental biology 22 (6), 572-578, 2011
Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice
LE Dow, Z Nasr, M Saborowski, SH Ebbesen, E Manchado, N Tasdemir, ...
PloS one 9 (4), e95236, 2014
SHP2 inhibition overcomes RTK-mediated pathway reactivation in KRAS-mutant tumors treated with MEK inhibitors
H Lu, C Liu, R Velazquez, H Wang, LM Dunkl, M Kazic-Legueux, ...
Molecular cancer therapeutics 18 (7), 1323-1334, 2019
The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors
M Eguren, E Porlan, E Manchado, I García-Higuera, M Cañamero, ...
Nature communications 4 (1), 1-16, 2013
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
M Guillamot, E Manchado, M Chiesa, G Gómez-López, DG Pisano, ...
Scientific reports 1 (1), 1-7, 2011
USP39 deubiquitinase is essential for KRAS oncogene-driven cancer
JM Fraile, E Manchado, A Lujambio, V Quesada, D Campos-Iglesias, ...
Journal of Biological Chemistry 292 (10), 4164-4175, 2017
Targeting aneuploidy for cancer therapy
E Manchado, M Malumbres
Cell 144 (4), 465-466, 2011
4th, Wagenblast E, Davis CA, Moon SH, Pfister NT, Tschaharganeh DF, Kitzing T, Aust D, Markert EK, Wu J, et al. Mutant p53 drives pancreatic cancer metastasis through cell …
S Weissmueller, E Manchado, M Saborowski, JP Morris
Cell 157, 382-94, 2014
A pipeline for drug target identification and validation
E Manchado, CH Huang, N Tasdemir, DF Tschaharganeh, JE Wilkinson, ...
Cold Spring Harbor symposia on quantitative biology 81, 257-267, 2016
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Articles 1–20