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Ellen Nollen
Ellen Nollen
University of Groningen, European Research Institute for the Biology of Aging
Adresă de e-mail confirmată pe umcg.nl
Titlu
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Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
M Platten, EAA Nollen, UF Röhrig, F Fallarino, CA Opitz
Nature reviews Drug discovery 18 (5), 379-401, 2019
8762019
Chaperoning signaling pathways: molecular chaperones as stress-sensingheat shock'proteins
EAA Nollen, RI Morimoto
Journal of cell science 115 (14), 2809-2816, 2002
8522002
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation
EAA Nollen, SM Garcia, G Van Haaften, S Kim, A Chavez, RI Morimoto, ...
Proceedings of the National Academy of Sciences 101 (17), 6403-6408, 2004
4972004
C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging
TJ Van Ham, KL Thijssen, R Breitling, RMW Hofstra, RHA Plasterk, ...
PLoS genetics 4 (3), e1000027, 2008
4572008
Polyglutamine protein aggregates are dynamic
S Kim, EAA Nollen, K Kitagawa, VP Bindokas, RI Morimoto
Nature cell biology 4 (10), 826-831, 2002
3472002
In vivo chaperone activity of heat shock protein 70 and thermotolerance
EAA Nollen, JF Brunsting, H Roelofsen, LA Weber, HH Kampinga
Molecular and cellular biology 19 (3), 2069-2079, 1999
3001999
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
2972017
Tryptophan metabolism in inflammaging: from biomarker to therapeutic target
FJH Sorgdrager, PJW Naudé, IP Kema, EA Nollen, PPD Deyn
Frontiers in Immunology 10, 2565, 2019
2452019
Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation
AT Van Der Goot, W Zhu, RP Vázquez-Manrique, RI Seinstra, K Dettmer, ...
Proceedings of the National Academy of Sciences 109 (37), 14912-14917, 2012
2142012
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ...
Science advances 2 (2), e1501244, 2016
2092016
Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity
EAA Nollen, JF Brunsting, J Song, HH Kampinga, RI Morimoto
Molecular and cellular biology 20 (3), 1083-1088, 2000
1782000
Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity
TJ van Ham, MA Holmberg, AT van der Goot, E Teuling, ...
Cell 142 (4), 601-612, 2010
1672010
A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans
M Koopman, H Michels, BM Dancy, R Kamble, L Mouchiroud, J Auwerx, ...
Nature protocols 11 (10), 1798-1816, 2016
1642016
Tryptophan metabolism: entering the field of aging and age-related pathologies
AT Van der Goot, EAA Nollen
Trends in molecular medicine 19 (6), 336-344, 2013
1642013
Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1
EAA Nollen, AE Kabakov, JF Brunsting, B Kanon, J Höhfeld, ...
Journal of Biological Chemistry 276 (7), 4677-4682, 2001
1502001
Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection
EAA Nollen, FA Salomons, JF Brunsting, JJL Want, OCM Sibon, ...
Proceedings of the National Academy of Sciences 98 (21), 12038-12043, 2001
1382001
Chaperone proteostasis in Parkinson's disease: Stabilization of the Hsp70/α‐synuclein complex by Hip
C Roodveldt, CW Bertoncini, A Andersson, AT Van Der Goot, ST Hsu, ...
The EMBO journal 28 (23), 3758-3770, 2009
1282009
Extracellular 4′-phosphopantetheine is a source for intracellular coenzyme A synthesis
B Srinivasan, M Baratashvili, M Van Der Zwaag, B Kanon, C Colombelli, ...
Nature chemical biology 11 (10), 784-792, 2015
1252015
Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing
IE Jansen, H Ye, S Heetveld, MC Lechler, H Michels, RI Seinstra, ...
Genome biology 18, 1-26, 2017
1202017
A FRET sensor for non‐invasive imaging of amyloid formation in vivo
GS Kaminski Schierle, CW Bertoncini, FTS Chan, AT Van Der Goot, ...
ChemPhysChem 12 (3), 673-680, 2011
1202011
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