Matthew Wright
Matthew Wright
Executive Director, Genentech
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Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly …
DJP Pinto, MJ Orwat, S Wang, JM Fevig, ML Quan, E Amparo, J Cacciola, ...
Journal of medicinal chemistry 44 (4), 566-578, 2001
Rational use of plasma protein and tissue binding data in drug design: miniperspective
X Liu, M Wright, CECA Hop
Journal of medicinal chemistry 57 (20), 8238-8248, 2014
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2
ML Quan, CD Ellis, AY Liauw, RS Alexander, RM Knabb, G Lam, ...
Journal of medicinal chemistry 42 (15), 2760-2773, 1999
Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants
PYS Lam, CG Clark, R Li, DJP Pinto, MJ Orwat, RA Galemmo, JM Fevig, ...
Journal of medicinal chemistry 46 (21), 4405-4418, 2003
Isoxazolines and isoxazoles as factor Xa inhibitors
JR Pruitt, DJ Pinto, MJ Estrella, LL Bostrom, RM Knabb, PC Wong, ...
Bioorganic & medicinal chemistry letters 10 (8), 685-689, 2000
Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent …
JR Pruitt, DJP Pinto, RA Galemmo, RS Alexander, KA Rossi, BL Wells, ...
Journal of medicinal chemistry 46 (25), 5298-5315, 2003
Drug concentration asymmetry in tissues and plasma for small molecule–related therapeutic modalities
D Zhang, CECA Hop, G Patilea-Vrana, G Gampa, HK Seneviratne, ...
Drug Metabolism and Disposition 47 (10), 1122-1135, 2019
Optimizing the use of cyclosporine in renal transplantation
I Sketris, R Yatscoff, P Keown, DM Canafax, MR First, DW Holt, ...
Clinical biochemistry 28 (3), 195-211, 1995
Nonsymmetric P2/P2 ‘cyclic urea HIV protease inhibitors. Structure− activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues
GV De Lucca, UT Kim, J Liang, B Cordova, RM Klabe, S Garber, ...
Journal of medicinal chemistry 41 (13), 2411-2423, 1998
Nonpeptide factor Xa inhibitors III: effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits
PC Wong, EJ Crain, CA Watson, AM Zaspel, MR Wright, PY Lam, ...
Journal of Pharmacology and Experimental Therapeutics 303 (3), 993-1000, 2002
Drug disposition and effects in the fetus.
DW Rurak, MR Wright, JE Axelson
Journal of developmental physiology 15 (1), 33-44, 1991
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase
GS Jones, F Yu, A Zeynalzadegan, J Hesselgesser, X Chen, J Chen, ...
Antimicrobial agents and chemotherapy 53 (3), 1194-1203, 2009
Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis
PC Wong, EJ Crain, RM Knabb, RP Meade, ML Quan, CA Watson, ...
Journal of Pharmacology and Experimental Therapeutics 295 (1), 212-218, 2000
Antiinflammatory drug-induced small intestinal permeability: the rat is a suitable model
NM Davies, MR Wright, F Jamali
Pharmaceutical research 11, 1652-1656, 1994
Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors
JD Rodgers, PYS Lam, BL Johnson, H Wang, SS Ko, SP Seitz, GL Trainor, ...
Chemistry & biology 5 (10), 597-608, 1998
Improved high-performance liquid chromatographic assay method for the enantiomers of ibuprofen
MR Wright, S Sattari, DR Brocks, F Jamali
Journal of Chromatography B: Biomedical Sciences and Applications 583 (2 …, 1992
Effect of the enantiomers of flurbiprofen, ibuprofen, and ketoprofen on intestinal permeability
NM Davies, MR Wright, AS Russell, F Jamali
Journal of pharmaceutical sciences 85 (11), 1170-1173, 1996
Limited extent of stereochemical conversion of chiral non-steroidal anti-inflammatory drugs induced by derivatization methods employing ethyl chloroformate
MR Wright, F Jamali
Journal of Chromatography B: Biomedical Sciences and Applications 616 (1), 59-65, 1993
Synthesis, antiviral activity and pharmacokinetics of P1/P1′ substituted 3-aminoindazole cyclic urea HIV protease inhibitors
RF Kaltenbach III, M Patel, RE Waltermire, GD Harris, BRP Stone, ...
Bioorganic & medicinal chemistry letters 13 (4), 605-608, 2003
Nonbenzamidine tetrazole derivatives as factor Xa inhibitors
ML Quan, CD Ellis, MY He, AY Liauw, FJ Woerner, RS Alexander, ...
Bioorganic & medicinal chemistry letters 13 (3), 369-373, 2003
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