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Michele Vendruscolo
Michele Vendruscolo
Professor of Biophysics, University of Cambridge
Adresă de e-mail confirmată pe cam.ac.uk - Pagina de pornire
Titlu
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The amyloid state and its association with protein misfolding diseases
TPJ Knowles, M Vendruscolo, CM Dobson
Nature reviews Molecular cell biology 15 (6), 384-396, 2014
23782014
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
SIA Cohen, S Linse, LM Luheshi, E Hellstrand, DA White, L Rajah, ...
Proceedings of the National Academy of Sciences 110 (24), 9758-9763, 2013
13772013
An analytical solution to the kinetics of breakable filament assembly
TPJ Knowles, CA Waudby, GL Devlin, SIA Cohen, A Aguzzi, ...
Science 326 (5959), 1533-1537, 2009
11822009
Role of intermolecular forces in defining material properties of protein nanofibrils
TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, ...
science 318 (5858), 1900-1903, 2007
8422007
Parmbsc1: a refined force field for DNA simulations
I Ivani, PD Dans, A Noy, A Pérez, I Faustino, A Hospital, J Walther, ...
Nature methods 13 (1), 55-58, 2016
8382016
ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function
T Murakami, S Qamar, JQ Lin, GSK Schierle, E Rees, A Miyashita, ...
Neuron 88 (4), 678-690, 2015
7932015
Simultaneous determination of protein structure and dynamics
K Lindorff-Larsen, RB Best, MA DePristo, CM Dobson, M Vendruscolo
Nature 433 (7022), 128-132, 2005
7892005
Mapping long-range interactions in α-synuclein using spin-label NMR and ensemble molecular dynamics simulations
MM Dedmon, K Lindorff-Larsen, J Christodoulou, M Vendruscolo, ...
Journal of the American Chemical Society 127 (2), 476-477, 2005
7872005
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions
H Olzscha, SM Schermann, AC Woerner, S Pinkert, MH Hecht, ...
Cell 144 (1), 67-78, 2011
7432011
FUS phase separation is modulated by a molecular chaperone and methylation of arginine cation-π interactions
S Qamar, GZ Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, ...
Cell 173 (3), 720-734. e15, 2018
7292018
Prediction of “aggregation-prone” and “aggregation-susceptible” regions in proteins associated with neurodegenerative diseases
AP Pawar, KF Dubay, J Zurdo, F Chiti, M Vendruscolo, CM Dobson
Journal of molecular biology 350 (2), 379-392, 2005
7132005
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, ...
Proceedings of the National Academy of Sciences 111 (21), 7671-7676, 2014
6742014
Protein structure determination from NMR chemical shifts
A Cavalli, X Salvatella, CM Dobson, M Vendruscolo
Proceedings of the National Academy of Sciences 104 (23), 9615-9620, 2007
6602007
Atomic structure and hierarchical assembly of a cross-β amyloid fibril
AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, ...
Proceedings of the National Academy of Sciences 110 (14), 5468-5473, 2013
6392013
Molecular mechanisms of protein aggregation from global fitting of kinetic models
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, ...
Nature protocols 11 (2), 252-272, 2016
6272016
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, ...
Nature chemical biology 11 (3), 229-234, 2015
6202015
The amyloid-β pathway in Alzheimer’s disease
H Hampel, J Hardy, K Blennow, C Chen, G Perry, SH Kim, VL Villemagne, ...
Molecular psychiatry 26 (10), 5481-5503, 2021
6022021
Widespread proteome remodeling and aggregation in aging C. elegans
DM Walther, P Kasturi, M Zheng, S Pinkert, G Vecchi, P Ciryam, ...
Cell 161 (4), 919-932, 2015
5752015
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, ...
Science 358 (6369), 1440-1443, 2017
5692017
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR
DM Korzhnev, X Salvatella, M Vendruscolo, AA Di Nardo, AR Davidson, ...
Nature 430 (6999), 586-590, 2004
5432004
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