| Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis SP Thayer, MP di Magliano, PW Heiser, CM Nielsen, DJ Roberts, ... Nature 425 (6960), 851-856, 2003 | 1946 | 2003 |
| Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK A Minden, A Lin, M McMahon, C Lange-Carter, B Dérijard, RJ Davis, ... Science 266 (5191), 1719-1723, 1994 | 1367 | 1994 |
| BrafV600E cooperates with Pten loss to induce metastatic melanoma D Dankort, DP Curley, RA Cartlidge, B Nelson, AN Karnezis, ... Nature genetics 41 (5), 544-552, 2009 | 1333 | 2009 |
| Senescence of human fibroblasts induced by oncogenic Raf J Zhu, D Woods, M McMahon, JM Bishop Genes & development 12 (19), 2997-3007, 1998 | 1022 | 1998 |
| Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance M Das Thakur, F Salangsang, AS Landman, WR Sellers, NK Pryer, ... Nature 494 (7436), 251-255, 2013 | 867 | 2013 |
| Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond M Holderfield, MM Deuker, F McCormick, M McMahon Nature Reviews Cancer 14 (7), 455-467, 2014 | 860 | 2014 |
| Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells RL Friedman, SP Manly, M McMahon, IM Kerr, GR Stark Cell 38 (3), 745-755, 1984 | 856 | 1984 |
| Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1 D Woods, D Parry, H Cherwinski, E Bosch, E Lees, M McMahon Molecular and cellular biology 17 (9), 5598-5611, 1997 | 789 | 1997 |
| A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors D Dankort, E Filenova, M Collado, M Serrano, K Jones, M McMahon Genes & development 21 (4), 379-384, 2007 | 580 | 2007 |
| An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background D Mitra, X Luo, A Morgan, J Wang, MP Hoang, J Lo, CR Guerrero, ... Nature 491 (7424), 449-453, 2012 | 549 | 2012 |
| Protective autophagy elicited by RAF→ MEK→ ERK inhibition suggests a treatment strategy for RAS-driven cancers CG Kinsey, SA Camolotto, AM Boespflug, KP Guillen, M Foth, A Truong, ... Nature medicine 25 (4), 620-627, 2019 | 548 | 2019 |
| The Hippo effector YAP promotes resistance to RAF-and MEK-targeted cancer therapies L Lin, AJ Sabnis, E Chan, V Olivas, L Cade, E Pazarentzos, S Asthana, ... Nature genetics 47 (3), 250-256, 2015 | 527 | 2015 |
| Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation M Onishi, T Nosaka, K Misawa, ALF Mui, D Gorman, M McMahon, ... Molecular and cellular biology 18 (7), 3871-3879, 1998 | 495 | 1998 |
| Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E–Driven Lung Tumors AM Strohecker, JY Guo, G Karsli-Uzunbas, SM Price, GJ Chen, R Mathew, ... Cancer discovery 3 (11), 1272-1285, 2013 | 457 | 2013 |
| Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF S Ries, C Biederer, D Woods, O Shifman, S Shirasawa, T Sasazuki, ... Cell 103 (2), 321-330, 2000 | 447 | 2000 |
| Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase ML Samuels, MJ Weber, JM Bishop, M McMahon Molecular and cellular biology, 1993 | 418 | 1993 |
| β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas WE Damsky, DP Curley, M Santhanakrishnan, LE Rosenbaum, JT Platt, ... Cancer cell 20 (6), 741-754, 2011 | 417 | 2011 |
| Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells K Lehmann, E Janda, CE Pierreux, M Rytömaa, A Schulze, M McMahon, ... Genes & development 14 (20), 2610-2622, 2000 | 384 | 2000 |
| Analysis of the transcriptional program induced by Raf in epithelial cells A Schulze, K Lehmann, HBJ Jefferies, M McMahon, J Downward Genes & development 15 (8), 981-994, 2001 | 337 | 2001 |
| A central role for RAF→ MEK→ ERK signaling in the genesis of pancreatic ductal adenocarcinoma EA Collisson, CL Trejo, JM Silva, S Gu, JE Korkola, LM Heiser, ... Cancer discovery 2 (8), 685-693, 2012 | 334 | 2012 |
