|Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis|
SP Thayer, MP di Magliano, PW Heiser, CM Nielsen, DJ Roberts, ...
Nature 425 (6960), 851-856, 2003
|Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK|
A Minden, A Lin, M McMahon, C Lange-Carter, B Dérijard, RJ Davis, ...
Science 266 (5191), 1719-1723, 1994
|BrafV600E cooperates with Pten loss to induce metastatic melanoma|
D Dankort, DP Curley, RA Cartlidge, B Nelson, AN Karnezis, ...
Nature genetics 41 (5), 544-552, 2009
|Senescence of human fibroblasts induced by oncogenic Raf|
J Zhu, D Woods, M McMahon, JM Bishop
Genes & development 12 (19), 2997-3007, 1998
|Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells|
RL Friedman, SP Manly, M McMahon, IM Kerr, GR Stark
Cell 38 (3), 745-755, 1984
|Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance|
M Das Thakur, F Salangsang, AS Landman, WR Sellers, NK Pryer, ...
Nature 494 (7436), 251-255, 2013
|Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1|
D Woods, D Parry, H Cherwinski, E Bosch, E Lees, M McMahon
Molecular and cellular biology 17 (9), 5598-5611, 1997
|Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond|
M Holderfield, MM Deuker, F McCormick, M McMahon
Nature Reviews Cancer 14 (7), 455-467, 2014
|A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors|
D Dankort, E Filenova, M Collado, M Serrano, K Jones, M McMahon
Genes & development 21 (4), 379-384, 2007
|An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background|
D Mitra, X Luo, A Morgan, J Wang, MP Hoang, J Lo, CR Guerrero, ...
Nature 491 (7424), 449-453, 2012
|Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation|
M Onishi, T Nosaka, K Misawa, ALF Mui, D Gorman, M McMahon, ...
Molecular and cellular biology 18 (7), 3871-3879, 1998
|The Hippo effector YAP promotes resistance to RAF-and MEK-targeted cancer therapies|
L Lin, AJ Sabnis, E Chan, V Olivas, L Cade, E Pazarentzos, S Asthana, ...
Nature genetics 47 (3), 250-256, 2015
|Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF|
S Ries, C Biederer, D Woods, O Shifman, S Shirasawa, T Sasazuki, ...
Cell 103 (2), 321-330, 2000
|Protective autophagy elicited by RAF→ MEK→ ERK inhibition suggests a treatment strategy for RAS-driven cancers|
CG Kinsey, SA Camolotto, AM Boespflug, KP Guillen, M Foth, A Truong, ...
Nature medicine 25 (4), 620-627, 2019
|Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E–Driven Lung TumorsAutophagy Promotes BrafV600E-Driven Lung Tumor Growth|
AM Strohecker, JY Guo, G Karsli-Uzunbas, SM Price, GJ Chen, R Mathew, ...
Cancer discovery 3 (11), 1272-1285, 2013
|Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase|
ML Samuels, MJ Weber, JM Bishop, M McMahon
Molecular and cellular biology 13 (10), 6241-6252, 1993
|β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas|
WE Damsky, DP Curley, M Santhanakrishnan, LE Rosenbaum, JT Platt, ...
Cancer cell 20 (6), 741-754, 2011
|Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells|
K Lehmann, E Janda, CE Pierreux, M Rytömaa, A Schulze, M McMahon, ...
Genes & development 14 (20), 2610-2622, 2000
|Analysis of the transcriptional program induced by Raf in epithelial cells|
A Schulze, K Lehmann, HBJ Jefferies, M McMahon, J Downward
Genes & development 15 (8), 981-994, 2001
|A Central Role for RAF→ MEK→ ERK Signaling in the Genesis of Pancreatic Ductal AdenocarcinomaA Central Role for RAF→ MEK→ ERK Signaling in the Genesis of Pancreatic Ductal …|
EA Collisson, CL Trejo, JM Silva, S Gu, JE Korkola, LM Heiser, ...
Cancer discovery 2 (8), 685-693, 2012