| Human IL-2 mutein with higher antitumor efficacy than wild type IL-2 T Carmenate, A Pacios, M Enamorado, E Moreno, K Garcia-Martínez, ... The Journal of Immunology 190 (12), 6230-6238, 2013 | 104 | 2013 |
| When three is not a crowd: a Crossregulation Model of the dynamics and repertoire selection of regulatory CD4+ T cells J Carneiro, K Leon, Í Caramalho, C Van Den Dool, R Gardner, V Oliveira, ... Immunological reviews 216 (1), 48-68, 2007 | 98 | 2007 |
| Tolerance and immunity in a mathematical model of T-cell mediated suppression K León, A Lage, J Carneiro Journal of theoretical biology 225 (1), 107-126, 2003 | 88 | 2003 |
| Modelling T-cell-mediated suppression dependent on interactions in multicellular conjugates K León, R Perez, A Lage, J Carneiro Journal of Theoretical Biology 207 (2), 231-254, 2000 | 86 | 2000 |
| A general mathematical framework to model generation structure in a population of asynchronously dividing cells K León, J Faro, J Carneiro Journal of theoretical biology 229 (4), 455-476, 2004 | 73 | 2004 |
| Immunological self-tolerance: Lessons from mathematical modeling J Carneiro, T Paixão, D Milutinovic, J Sousa, K Leon, R Gardner, J Faro Journal of Computational and Applied Mathematics 184 (1), 77-100, 2005 | 68 | 2005 |
| SARS-CoV-2 RBD-Tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies Y Valdes-Balbin, D Santana-Mederos, L Quintero, S Fernández, ... ACS Chemical Biology 16 (7), 1223-1233, 2021 | 51 | 2021 |
| Autoimmunization to epidermal growth factor, a component of the immunological homunculus G Gonzalez, E Montero, K Leon, IR Cohen, A Lage Autoimmunity reviews 1 (1-2), 89-95, 2002 | 47 | 2002 |
| Molecular aspects concerning the use of the SARS-CoV-2 receptor binding domain as a target for preventive vaccines Y Valdes-Balbin, D Santana-Mederos, F Paquet, S Fernandez, Y Climent, ... ACS central science 7 (5), 757-767, 2021 | 42 | 2021 |
| Inverse correlation between the incidences of autoimmune disease and infection predicted by a model of T cell mediated tolerance K León, J Faro, A Lage, J Carneiro Journal of Autoimmunity 22 (1), 31-42, 2004 | 41 | 2004 |
| How regulatory CD25+ CD4+ T cells impinge on tumor immunobiology? On the existence of two alternative dynamical classes of tumors K Leon, K Garcia, J Carneiro, A Lage Journal of Theoretical Biology 247 (1), 122-137, 2007 | 37 | 2007 |
| Therapeutic approaches to target cancer stem cells A Diaz, K Leon Cancers 3 (3), 3331-3352, 2011 | 34 | 2011 |
| Geometric and chemical patterns of interaction in protein–ligand complexes and their application in docking E Moreno, K León Proteins: Structure, Function, and Bioinformatics 47 (1), 1-13, 2002 | 32 | 2002 |
| How regulatory CD25+ CD4+ T cells impinge on tumor immunobiology: the differential response of tumors to therapies K Leon, K Garcia, J Carneiro, A Lage The Journal of Immunology 179 (9), 5659-5668, 2007 | 31 | 2007 |
| Three-cell interactions in T cell-mediated suppression? A mathematical analysis of its quantitative implications K León, R Peréz, A Lage, J Carneiro The journal of immunology 166 (9), 5356-5365, 2001 | 31 | 2001 |
| An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients D Saavedra, AL Añé-Kourí, N Sánchez, LM Filgueira, J Betancourt, ... Immunity & Ageing 17 (1), 1-8, 2020 | 30 | 2020 |
| Use of a humanized anti-CD6 monoclonal antibody (itolizumab) in elderly patients with moderate COVID-19 Y Díaz, M Ramos-Suzarte, Y Martín, NA Calderón, W Santiago, O Viñet, ... Gerontology 66 (6), 553-561, 2020 | 30 | 2020 |
| Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: a versatile platform for fine epitope mapping G Rojas, A Pupo, K Leon, J Avellanet, T Carmenate, S Sidhu Immunobiology 218 (1), 105-113, 2013 | 27 | 2013 |
| Characterizing steady states of genome-scale metabolic networks in continuous cell cultures J Fernandez-de-Cossio-Diaz, K Leon, R Mulet PLoS computational biology 13 (11), e1005835, 2017 | 26 | 2017 |
| IL-2 derivative polypeptides KL Monzón, TC Portilla, SP Rodriguez, NME Escalona, ABL Dávila US Patent 9,206,243, 2015 | 26 | 2015 |
Jorge CarneiroInstituto Gulbenkian de CiênciaVerified email at igc.gulbenkian.pt
