Kalet Leon Monzon
Kalet Leon Monzon
Center of Molecular Immunology, Habana, Cuba
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Human IL-2 mutein with higher antitumor efficacy than wild type IL-2
T Carmenate, A Pacios, M Enamorado, E Moreno, K Garcia-Martínez, ...
The Journal of Immunology 190 (12), 6230-6238, 2013
When three is not a crowd: a Crossregulation Model of the dynamics and repertoire selection of regulatory CD4+ T cells
J Carneiro, K Leon, Í Caramalho, C Van Den Dool, R Gardner, V Oliveira, ...
Immunological reviews 216 (1), 48-68, 2007
Tolerance and immunity in a mathematical model of T-cell mediated suppression
K León, A Lage, J Carneiro
Journal of theoretical biology 225 (1), 107-126, 2003
SARS-CoV-2 RBD-tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies
Y Valdes-Balbin, D Santana-Mederos, L Quintero, S Fernández, ...
ACS Chemical Biology 16 (7), 1223-1233, 2021
Modelling T-cell-mediated suppression dependent on interactions in multicellular conjugates
K Leon, R Perez, A Lage, J Carneiro
Journal of Theoretical Biology 207 (2), 231-254, 2000
A general mathematical framework to model generation structure in a population of asynchronously dividing cells
K León, J Faro, J Carneiro
Journal of theoretical biology 229 (4), 455-476, 2004
Immunological self-tolerance: Lessons from mathematical modeling
J Carneiro, T Paixão, D Milutinovic, J Sousa, K Leon, R Gardner, J Faro
Journal of Computational and Applied Mathematics 184 (1), 77-100, 2005
Molecular aspects concerning the use of the SARS-CoV-2 receptor binding domain as a target for preventive vaccines
Y Valdes-Balbin, D Santana-Mederos, F Paquet, S Fernandez, Y Climent, ...
ACS central science 7 (5), 757-767, 2021
Autoimmunization to epidermal growth factor, a component of the immunological homunculus
G Gonzalez, E Montero, K Leon, IR Cohen, A Lage
Autoimmunity reviews 1 (1-2), 89-95, 2002
Inverse correlation between the incidences of autoimmune disease and infection predicted by a model of T cell mediated tolerance
K León, J Faro, A Lage, J Carneiro
Journal of Autoimmunity 22 (1), 31-42, 2004
Blocking IL-2 signal in vivo with an IL-2 antagonist reduces tumor growth through the control of regulatory T cells
T Carmenate, Y Ortíz, M Enamorado, K García-Martínez, J Avellanet, ...
The Journal of Immunology 200 (10), 3475-3484, 2018
IL-2 derivative polypeptides
KL Monzón, TC Portilla, SP Rodriguez, NME Escalona, ABL Dávila
US Patent 9,206,243, 2015
How regulatory CD25+ CD4+ T cells impinge on tumor immunobiology? On the existence of two alternative dynamical classes of tumors
K Leon, K Garcia, J Carneiro, A Lage
Journal of theoretical biology 247 (1), 122-137, 2007
Use of a humanized anti-CD6 monoclonal antibody (itolizumab) in elderly patients with moderate COVID-19
Y Díaz, M Ramos-Suzarte, Y Martín, NA Calderón, W Santiago, O Viñet, ...
Gerontology 66 (6), 553-561, 2020
An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients
D Saavedra, AL Añé-Kourí, N Sánchez, LM Filgueira, J Betancourt, ...
Immunity & Ageing 17, 1-8, 2020
Characterizing steady states of genome-scale metabolic networks in continuous cell cultures
J Fernandez-de-Cossio-Diaz, K Leon, R Mulet
PLoS computational biology 13 (11), e1005835, 2017
Therapeutic approaches to target cancer stem cells
A Diaz, K Leon
Cancers 3 (3), 3331-3352, 2011
Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: a versatile platform for fine epitope mapping
G Rojas, A Pupo, K Leon, J Avellanet, T Carmenate, S Sidhu
Immunobiology 218 (1), 105-113, 2013
Geometric and chemical patterns of interaction in protein–ligand complexes and their application in docking
E Moreno, K León
Proteins: Structure, Function, and Bioinformatics 47 (1), 1-13, 2002
How regulatory CD25+ CD4+ T cells impinge on tumor immunobiology: the differential response of tumors to therapies
K Leon, K Garcia, J Carneiro, A Lage
The Journal of Immunology 179 (9), 5659-5668, 2007
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