Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain LG Friedman, ML Lachenmayer, J Wang, L He, SM Poulose, M Komatsu, ... Journal of Neuroscience 32 (22), 7585-7593, 2012 | 316 | 2012 |
The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases Z Yue, L Friedman, M Komatsu, K Tanaka Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1793 (9), 1496-1507, 2009 | 212 | 2009 |
Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease LG Friedman, YH Qureshi, WH Yu Neurotherapeutics 12 (1), 94-108, 2015 | 99 | 2015 |
Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development F Gori, LG Friedman, MB Demay Developmental biology 295 (2), 498-506, 2006 | 60 | 2006 |
Potential application of grape derived polyphenols in Huntington’s disease J Wang, CM Pfleger, L Friedman, R Vittorino, W Zhao, X Qian, L Conley, ... Translational neuroscience 1, 95-100, 2010 | 45 | 2010 |
Cadherin-based transsynaptic networks in establishing and modifying neural connectivity LG Friedman, DL Benson, GW Huntley Current topics in developmental biology 112, 415-465, 2015 | 42 | 2015 |
Cadherin‐8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits LG Friedman, FW Riemslagh, JM Sullivan, R Mesias, FM Williams, ... Journal of Comparative Neurology 523 (1), 75-92, 2015 | 34 | 2015 |
Value-generating exploratory trials in neurodegenerative dementias LG Friedman, N McKeehan, Y Hara, JL Cummings, DC Matthews, J Zhu, ... Neurology 96 (20), 944-954, 2021 | 22 | 2021 |
Guidelines to improve animal study design and reproducibility for Alzheimer's disease and related dementias: For funders and researchers HM Snyder, DW Shineman, LG Friedman, JA Hendrix, A Khachaturian, ... Alzheimer's & Dementia 12 (11), 1177-1185, 2016 | 21 | 2016 |
Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo F Gori, L Friedman, MB Demay JOURNAL OF MUSCULOSKELETAL AND NEURONAL INTERACTIONS 5 (4), 338, 2005 | 21 | 2005 |
Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy CM Pfleger, J Wang, L Friedman, R Vittorino, LM Conley, L Ho, ... International Journal of Alzheimer’s Disease 2010, 2010 | 11 | 2010 |
Meeting report on the Alzheimer’s drug discovery foundation 14th international conference on Alzheimer’s drug discovery LG Friedman, K Price, RF Lane, AJ Carman, PA Dacks, DW Shineman, ... Alzheimer's Research & Therapy 6, 1-4, 2014 | 7 | 2014 |
Optimizing the use of CROs by academia and small companies RF Lane, LG Friedman, C Keith, SP Braithwaite, JA Frearson, DA Lowe, ... Nature reviews Drug discovery 12 (7), 487-488, 2013 | 7 | 2013 |
Commentary: Global Alzheimer's disease and Alzheimer's disease related dementia research funding organizations support and engage the research community throughout the COVID‐19 … EA Meyers, P Amouyel, DE Bovenkamp, MC Carrillo, GD De Buchy, ... Alzheimer's & Dementia 18 (5), 1067-1070, 2022 | 4 | 2022 |
Development and cadherin-mediated control of prefrontal corticostriatal projections in mice RE Mesías, Y Zaki, CA Guevara, LG Friedman, A Hussein, K Therrien, ... Iscience 26 (10), 2023 | | 2023 |
Development of prefrontal corticostriatal connectivity in mice RE Mesías, Y Zaki, CA Guevara, LG Friedman, A Hussein, K Therrien, ... bioRxiv, 2023.03. 14.532475, 2023 | | 2023 |
Valley of Death and the Role of Venture Philanthropy in Alzheimer’s Disease Drug Development LG Friedman, M Owen, A Travaglia, H Fillit Alzheimer's Disease Drug Development: Research and Development Ecosystem, 480, 2022 | | 2022 |
Molecular Mechanisms Underlying Striatal Circuitry in Development and Degeneration LG Friedman Icahn School of Medicine at Mount Sinai, 2014 | | 2014 |
AUTOPHAGY IN HUNTINGTON’S AND PARKINSON’S DISEASES: PATHOGENIC MECHANISMS AND THERAPEUTIC POTENTIALS J Lim, LG Friedman, NC McKnight, Z Yue Autophagy of the Nervous System: Cellular Self-Digestion in Neurons and …, 2012 | | 2012 |