| A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication C Evrin, P Clarke, J Zech, R Lurz, J Sun, S Uhle, H Li, B Stillman, C Speck Proceedings of the National Academy of Sciences 106 (48), 20240-20245, 2009 | 608 | 2009 |
| Evidence for distinct substrate specificities of importin α family members in nuclear protein import M Köhler, C Speck, M Christiansen, FR Bischoff, S Prehn, H Haller, ... Molecular and cellular biology 19 (11), 7782-7791, 1999 | 431 | 1999 |
| ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA C Speck, Z Chen, H Li, B Stillman Nature structural & molecular biology 12 (11), 965-971, 2005 | 305 | 2005 |
| Mechanism of origin unwinding: sequential binding of DnaA to double‐and single‐stranded DNA C Speck, W Messer The EMBO journal, 2001 | 234 | 2001 |
| ATP–and ADP–DnaA protein, a molecular switch in gene regulation C Speck, C Weigel, W Messer The EMBO journal, 1999 | 211 | 1999 |
| Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA J Sun, C Evrin, SA Samel, A Fernández-Cid, A Riera, H Kawakami, ... Nature structural & molecular biology 20 (8), 944-951, 2013 | 161 | 2013 |
| Analysis of protein–DNA interactions using surface plasmon resonance J Majka, C Speck Analytics of protein–DNA interactions, 13-36, 2007 | 161 | 2007 |
| An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly A Fernández-Cid, A Riera, S Tognetti, MC Herrera, S Samel, C Evrin, ... Molecular cell 50 (4), 577-588, 2013 | 152 | 2013 |
| Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma Y Yu, K Schleich, B Yue, S Ji, P Lohneis, K Kemper, MR Silvis, N Qutob, ... Cancer cell 33 (2), 322-336. e8, 2018 | 142 | 2018 |
| Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1 Z Yuan, A Riera, L Bai, J Sun, S Nandi, C Spanos, ZA Chen, M Barbon, ... Nature structural & molecular biology 24 (3), 316-324, 2017 | 142 | 2017 |
| An integrated workflow for crosslinking mass spectrometry ML Mendes, L Fischer, ZA Chen, M Barbon, FJ O'Reilly, SH Giese, ... Molecular systems biology 15 (9), e8994, 2019 | 138 | 2019 |
| Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function J Sun, A Fernandez-Cid, A Riera, S Tognetti, Z Yuan, B Stillman, C Speck, ... Genes & development 28 (20), 2291-2303, 2014 | 122 | 2014 |
| Bacterial replication initiator DnaA. Rules for DnaA binding and rolesof DnaA in origin unwinding and helicase loading W Messer, F Blaesing, D Jakimowicz, M Krause, J Majka, J Nardmann, ... Biochimie 83 (1), 5-12, 2001 | 122 | 2001 |
| Cdc6 ATPase activity regulates ORC· Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication C Speck, B Stillman Journal of Biological Chemistry 282 (16), 11705-11714, 2007 | 119 | 2007 |
| A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA SA Samel, A Fernández-Cid, J Sun, A Riera, S Tognetti, MC Herrera, H Li, ... Genes & development 28 (15), 1653-1666, 2014 | 116 | 2014 |
| Functional domains of DnaA proteins W Messer, F Blaesing, J Majka, J Nardmann, S Schaper, A Schmidt, ... Biochimie 81 (8-9), 819-825, 1999 | 107 | 1999 |
| From structure to mechanism—understanding initiation of DNA replication A Riera, M Barbon, Y Noguchi, LM Reuter, S Schneider, C Speck Genes & development 31 (11), 1073-1088, 2017 | 102 | 2017 |
| Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy J Sun, H Kawakami, J Zech, C Speck, B Stillman, H Li Structure 20 (3), 534-544, 2012 | 89 | 2012 |
| Structural elements of the Streptomyces oriC region and their interactions with the DnaA protein D Jakimowicz, J Majka, W Messer, C Speck, M Fernandez, M Cruz Martin, ... Microbiology 144 (5), 1281-1290, 1998 | 86 | 1998 |
| The Escherichia coli SeqA protein binds specifically and co‐operatively to two sites in hemimethylated and fully methylated oriC K Skarstad, G Lueder, R Lurz, C Speck, W Messer Molecular Microbiology 36 (6), 1319-1326, 2000 | 84 | 2000 |
Huilin LiProfessor, Department of Structure Biology, Van Andel InstituteVerified email at vai.org
