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Robert Kastelein
Robert Kastelein
Synthekine
Verified email at synthekine.com
Title
Cited by
Cited by
Year
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
CL Langrish, Y Chen, WM Blumenschein, J Mattson, B Basham, ...
The Journal of experimental medicine 201 (2), 233-240, 2005
54232005
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
J Schmitz, A Owyang, E Oldham, Y Song, E Murphy, TK McClanahan, ...
Immunity 23 (5), 479-490, 2005
43782005
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
DJ Cua, J Sherlock, YI Chen, CA Murphy, B Joyce, B Seymour, L Lucian, ...
Nature 421 (6924), 744-748, 2003
38032003
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
B Oppmann, R Lesley, B Blom, JC Timans, Y Xu, B Hunte, F Vega, N Yu, ...
Immunity 13 (5), 715-725, 2000
36872000
Development, cytokine profile and function of human interleukin 17–producing helper T cells
NJ Wilson, K Boniface, JR Chan, BS McKenzie, WM Blumenschein, ...
Nature immunology 8 (9), 950-957, 2007
26212007
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
N Kadowaki, S Ho, S Antonenko, R de Waal Malefyt, RA Kastelein, ...
The Journal of experimental medicine 194 (6), 863-870, 2001
25982001
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
V Soumelis, PA Reche, H Kanzler, W Yuan, G Edward, B Homey, M Gilliet, ...
Nature immunology 3 (7), 673-680, 2002
25542002
A family of human receptors structurally related to Drosophila Toll
FL Rock, G Hardiman, JC Timans, RA Kastelein, JF Bazan
Proceedings of the National Academy of Sciences 95 (2), 588-593, 1998
25441998
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via …
R de Waal Malefyt, J Haanen, H Spits, MG Roncarolo, A te Velde, ...
The Journal of experimental medicine 174 (4), 915-924, 1991
23501991
Divergent pro-and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
CA Murphy, CL Langrish, Y Chen, W Blumenschein, T McClanahan, ...
The Journal of experimental medicine 198 (12), 1951-1957, 2003
22462003
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
D Yen, J Cheung, H Scheerens, F Poulet, T McClanahan, B McKenzie, ...
The Journal of clinical investigation 116 (5), 1310-1316, 2006
20032006
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
S Pflanz, JC Timans, J Cheung, R Rosales, H Kanzler, J Gilbert, L Hibbert, ...
Immunity 16 (6), 779-790, 2002
18432002
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R
C Parham, M Chirica, J Timans, E Vaisberg, M Travis, J Cheung, S Pflanz, ...
The Journal of Immunology 168 (11), 5699-5708, 2002
17222002
Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria
FAW Verreck, T de Boer, DML Langenberg, MA Hoeve, M Kramer, ...
Proceedings of the National Academy of Sciences 101 (13), 4560-4565, 2004
12652004
The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
G Trinchieri, S Pflanz, RA Kastelein
Immunity 19 (5), 641-644, 2003
12432003
IL-23 promotes tumour incidence and growth
JL Langowski, X Zhang, L Wu, JD Mattson, T Chen, K Smith, B Basham, ...
Nature 442 (7101), 461-465, 2006
12382006
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4CD8 entheseal resident T cells
JP Sherlock, B Joyce-Shaikh, SP Turner, CC Chao, M Sathe, J Grein, ...
Nature medicine 18 (7), 1069-1076, 2012
11652012
Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.
P Vieira, R de Waal-Malefyt, MN Dang, KE Johnson, R Kastelein, ...
Proceedings of the National Academy of Sciences 88 (4), 1172-1176, 1991
10711991
Understanding the IL-23–IL-17 immune pathway
BS McKenzie, RA Kastelein, DJ Cua
Trends in immunology 27 (1), 17-23, 2006
10662006
IL‐12 and IL‐23: master regulators of innate and adaptive immunity
CL Langrish, BS McKenzie, NJ Wilson, R de Waal Malefyt, RA Kastelein, ...
Immunological reviews 202 (1), 96-105, 2004
9712004
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